Laquinimod

Generic Name
Laquinimod
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C19H17ClN2O3
CAS Number
248281-84-7
Unique Ingredient Identifier
908SY76S4G
Background

Laquinimod is an immunomodulator developed by Active Biotech and produced by Teva Pharmaceutical Industries. It is currently under development in phase III trials for treatment of multiple sclerosis as an oral therapy, like fingolimod. It has been shown to reduce disease activity on magnetic resonance imaging and to be well tolerated orally.

Indication

Investigated for use/treatment in multiple sclerosis.

Associated Conditions
-
Associated Therapies
-

A Study of Laquinimod Eye-drops in Healthy Participants

Phase 1
Completed
Conditions
Interventions
First Posted Date
2022-01-11
Last Posted Date
2023-01-31
Lead Sponsor
Active Biotech AB
Target Recruit Count
54
Registration Number
NCT05187403
Locations
🇦🇹

Clinical trial center at Medical University Vienna, Vienna, Austria

A Phase 2 Clinical Study in Subjects With Primary Progressive Multiple Sclerosis to Assess the Efficacy, Safety and Tolerability of Two Oral Doses of Laquinimod Either of 0.6 mg/Day or 1.5mg/Day (Experimental Drug) as Compared to Placebo

First Posted Date
2014-11-06
Last Posted Date
2022-03-10
Lead Sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Target Recruit Count
374
Registration Number
NCT02284568
Locations
🇩🇪

Teva Investigational Site 32512, Bamberg, Germany

🇩🇪

Teva Investigational Site 32505, Bad Mergentheim, Germany

🇩🇪

Teva Investigational Site 32523, Trier, Germany

and more 96 locations

A Clinical Study in Participants With Huntington's Disease (HD) to Assess Efficacy and Safety of Three Oral Doses of Laquinimod

Phase 2
Completed
Conditions
Interventions
First Posted Date
2014-08-13
Last Posted Date
2020-05-04
Lead Sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Target Recruit Count
352
Registration Number
NCT02215616
Locations
🇨🇦

Teva Investigational Site 11079, Toronto, Ontario, Canada

🇺🇸

Teva Investigational Site 12567, San Francisco, California, United States

🇺🇸

Teva Investigational Site 12565, Los Angeles, California, United States

and more 50 locations

A Phase I Study in Young Healthy Women to Investigate the Effects of Laquinimod on Standard Oral Contraceptive When Both Treatments Are Given Together

First Posted Date
2014-03-13
Last Posted Date
2021-11-09
Lead Sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Target Recruit Count
40
Registration Number
NCT02085863
Locations
🇩🇪

Teva Investigational Site 32415, Moenchengladbach, Germany

The Efficacy, Safety, and Tolerability of Laquinimod in Participants With Relapsing Remitting Multiple Sclerosis (RRMS)

Phase 3
Completed
Conditions
Interventions
First Posted Date
2012-10-16
Last Posted Date
2021-11-09
Lead Sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Target Recruit Count
2199
Registration Number
NCT01707992
Locations
🇺🇸

Teva Investigational Site 10315, Sunrise, Florida, United States

🇺🇸

Teva Investigational Site 10342, Tucson, Arizona, United States

🇺🇸

Teva Investigational Site 10341, Saint Petersburg, Florida, United States

and more 281 locations

A Study of Laquinimod in Participants With Systemic Lupus Erythematosus (SLE) Active Lupus Arthritis

Phase 2
Completed
Conditions
Interventions
First Posted Date
2010-03-11
Last Posted Date
2022-07-07
Lead Sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Target Recruit Count
82
Registration Number
NCT01085084
Locations
🇺🇸

Teva Investigational Site 1366, Charleston, South Carolina, United States

🇺🇸

Teva Investigational Site 1369, Bronx, New York, United States

🇨🇦

Teva Investigational Site 1142, Montreal, Quebec, Canada

and more 19 locations

A Study of Laquinimod in Participants With Systemic Lupus Erythematosus (SLE) Active Lupus Nephritis

First Posted Date
2010-03-11
Last Posted Date
2022-03-09
Lead Sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Target Recruit Count
46
Registration Number
NCT01085097
Locations
🇺🇸

Teva Investigational Site 1022, Lake Success, New York, United States

🇬🇧

Teva Investigational Site 3412, Dudley, United Kingdom

🇨🇦

Teva Investigational Site 1114, Winnipeg, Manitoba, Canada

and more 27 locations

A Study to Evaluate the Long-term Safety, Tolerability and Effect of Daily Oral Laquinimod 0.6 mg on Disease Course in Subjects With Relapsing Multiple Sclerosis

Phase 3
Terminated
Conditions
Interventions
First Posted Date
2010-01-12
Last Posted Date
2021-12-09
Lead Sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Target Recruit Count
1047
Registration Number
NCT01047319
Locations
🇺🇸

Teva Investigational Site 1267, Homewood, Alabama, United States

🇺🇸

Teva Investigational Site 1275, Atlanta, Georgia, United States

🇺🇸

Teva Investigational Site 1272, Pasadena, California, United States

and more 141 locations

A Study To Evaluate the Long-Term Safety, Tolerability and Effect on Disease Course

Phase 3
Terminated
Conditions
Interventions
First Posted Date
2009-10-01
Last Posted Date
2021-12-09
Lead Sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Target Recruit Count
839
Registration Number
NCT00988052
Locations
🇧🇬

Teva Investigational Site 5904, Sofia, Bulgaria

🇨🇦

Teva Investigational Site 1132, Bedford, Nova Scotia, Canada

🇬🇪

Teva Investigational Site 8100, Tbilisi, Georgia

and more 132 locations
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