Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. In vitro...
For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in t...
Ludwig Maximilians University, Munich, Germany
Memorial Sloan Kettering Cancer Center, New York, New York, United States
St. Jude Children's Research Hospital, Memphis, Tennessee, United States
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia, United States
Children's Hospital of Alabama, Birmingham, Alabama, United States
Children's Hospital Los Angeles, Los Angeles, California, United States
Moffitt Cancer Center ( Site 0261), Tampa, Florida, United States
START Midwest ( Site 0267), Grand Rapids, Michigan, United States
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0260), Hackensack, New Jersey, United States
M D Anderson Cancer Center, Houston, Texas, United States
M D Anderson Cancer Center, Houston, Texas, United States
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan
China Medical University Hospital, Taichung, Taiwan
Taichung Veterans General Hospital, Taichung, Taiwan
Sichuan University West China Hospital, Chengdu, Sichuan, China
Children's Hospital and Institute of Child Health, Multan, Punjab, Pakistan
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.