萘替芬 (Naftin)

概览

Naftifine is an antifungal agent used to treat infections of the Tinea, Trichophyton, and Epidermophyton species.

作用机制

Although the exact mechanism of action against fungi is not known, naftifine appears to interfere with sterol biosynthesis by inhibiting the enzyme squalene 2,3-epoxidase. This inhibition of enzyme activity results in decreased amounts of sterols, especially ergosterol, and a corresponding accumulation of squalene in the cells.

适应症

For the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.

• Tinea Corporis
• Tinea Cruris
• Tinea Pedis