Magnesium sulfate

Generic Name
Magnesium sulfate
Brand Names
Concept Ob, Suflave, Suprep Bowel Prep Kit, Tis-U-sol
Drug Type
Small Molecule
Chemical Formula
MgO4S
CAS Number
7487-88-9
Unique Ingredient Identifier
ML30MJ2U7I
Background

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 199...

Indication

Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also ...

Associated Conditions
Constipation, Convulsions, Hypomagnesemia, Torsades de Pointes, Barium poisoning, Severe Exacerbation of asthma
Associated Therapies
Bowel preparation therapy, Soaking aid for minor sprains and bruises
nature.com
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Phase-transformable metal-organic polyhedra for membrane processing and switchable gas

Materials and synthesis methods for various metal-organic polyhedra (MOPs) and polymeric ligands are detailed, including rhodium acetate, 5-(dodecyloxy)isophthalic acid, C12RhMOPs, HRhMOPs, OHRhMOPs, and 1-dodecyl-1H-imidazole. Characterization techniques such as UV-visible spectroscopy, NMR, DSC, XRD, DLS, and gas sorption are described. Gas separation setup and analysis methods for single-gas and mixed-gas permeation tests are also outlined.

A comparison of efficacy of erector spinae plane block versus serratus anterior ...

A prospective, blinded, randomised clinical trial at Galway University Hospital comparing two regional analgesia techniques for elective LSG surgery, aiming to assess quality of recovery at 24h using the QoR-15 score as the primary outcome. Secondary outcomes include pain scores, opioid consumption, and postoperative complications. Recruitment began in March 2023 and will span 24 months, targeting 70 patients.
cochrane.org
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Inexpensive drug can prevent cerebral palsy in premature babies

A new Cochrane Library Editorial calls for global implementation of antenatal magnesium sulphate to prevent cerebral palsy in preterm babies. The drug, costing around £5 per dose, has been confirmed by a recent Cochrane review to reduce cerebral palsy rates by 30%. Despite WHO recommendation since 2015, widespread implementation remains a challenge. Successful programs like PReCePT in England have shown significant impact, but global uptake is still incomplete, especially in low-resource settings.

Synbiotics in patients at risk for spontaneous preterm birth: protocol for a multi-centre

Pregnant women at risk for sPTB will be randomized to receive synbiotics or placebo from 8-10 weeks gestation until delivery. The synbiotic contains eight Lactobacillus strains, inulin, FOS, and D-mannose. Adherence will be monitored via diaries, and standard care protocols for sPTB prevention will be followed. Primary outcomes include gestational age at delivery and PTB rates, with secondary outcomes covering neonatal and microbiome analyses.
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