Dihydroergocristine

概览

Dihydroergocristine is an ergot alkaloid used to delay progressive mental decline in conditions like Alzheimer's.

作用机制

Dihydroergocristine mechanism of action seems to be related to a noncompetitive antagonistic activity in the serotonin receptors as well as a double partial agonist/antagonist activity in dopaminergic and adrenergic receptors. In Alzheimer studies, dihydroergocristine act as a direct inhibitor of γ-secretase.

适应症

Dihydroergocristine is used in some countries such as Brasil as a single agent for the treatment of cerebral and peripheric vascular events. To know more about dihydroergocristine as part of the ergoloid mesylate mixture, please visit Ergoloid mesylate.

• Cerebrovascular Diseases
• Cognitive Functioning
• Reduction of Blood Flow
• Vascular Diseases of the Extremities
• Vascular Disorders
• No primary neurological disease, idiopathic decreased mental activity