Remimazolam
- Generic Name
- Remimazolam
- Brand Names
- Byfavo
- Drug Type
- Small Molecule
- Chemical Formula
- C21H19BrN4O2
- CAS Number
- 308242-62-8
- Unique Ingredient Identifier
- 7V4A8U16MB
- Background
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.
- Indication
Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.
- Associated Conditions
- Procedural Sedation
- Associated Therapies
- -
Effect of Remimazolam on Postoperative Delirium
- Conditions
- General Anesthetic Drug Adverse Reaction
- Interventions
- First Posted Date
- 2023-12-26
- Last Posted Date
- 2023-12-26
- Lead Sponsor
- Zhihong LU
- Target Recruit Count
- 190
- Registration Number
- NCT06180876
- Locations
- 🇨🇳
Xijing hospital, Fourth military medical university, Xi'an, Shaanxi, China
Dose of Remimazolam in Children for Intubation
- First Posted Date
- 2023-12-14
- Last Posted Date
- 2023-12-14
- Lead Sponsor
- Zhihong LU
- Target Recruit Count
- 40
- Registration Number
- NCT06170918
Comparison of Procedural Sedation in TEE
- First Posted Date
- 2023-11-13
- Last Posted Date
- 2024-10-10
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 120
- Registration Number
- NCT06129188
ED90 of Remimazolam Anesthesia Induction in Painless Bidirectional Endoscopy in Children
- First Posted Date
- 2023-11-08
- Last Posted Date
- 2024-10-26
- Lead Sponsor
- Tongji Hospital
- Target Recruit Count
- 114
- Registration Number
- NCT06121609
- Locations
- 🇨🇳
Tongji Hospital, Wuhan, Hubei, China
Remimazolam vs. Propofol: Impact on Postoperative Delirium in Neurosurgical Patients
- Conditions
- Postoperative Delirium
- Interventions
- First Posted Date
- 2023-11-02
- Last Posted Date
- 2024-04-17
- Lead Sponsor
- Samsung Medical Center
- Target Recruit Count
- 696
- Registration Number
- NCT06115031
- Locations
- 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of
Esketamine Combined With Remimazolam on Postoperative Sleep Disturbance and Anxiety in Patients
- Conditions
- Sleep Disturbance
- Interventions
- First Posted Date
- 2023-10-31
- Last Posted Date
- 2024-04-16
- Lead Sponsor
- Tianjin Medical University General Hospital
- Target Recruit Count
- 400
- Registration Number
- NCT06108830
- Locations
- 🇨🇳
Tianjin Medical University General Hospital, Tianjin, China
Remimazolam Versus Propofol for General Anesthesia Induction in Patients on Renin-angiotensin System Blockers Undergoing Robot-assisted Laparoscopic Prostatectomy
- First Posted Date
- 2023-10-23
- Last Posted Date
- 2024-12-12
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 112
- Registration Number
- NCT06093971
- Locations
- 🇰🇷
Yonsei University College of Medicine, Seoul, Korea, Republic of
The Study of Ciprofol for the Suppression of Cardiovascular Responses to Tracheal Intubation
- Conditions
- Intubation, IntratrachealAdverse Effects
- Interventions
- First Posted Date
- 2023-10-23
- Last Posted Date
- 2023-10-23
- Lead Sponsor
- The Second Affiliated Hospital of Hainan Medical University
- Target Recruit Count
- 150
- Registration Number
- NCT06095570
- Locations
- 🇨🇳
The Second Affiliated Hospital of Hainan Medical University, Hai Kou, China, Haikou, Hainan, China
COnventional vs. Optimised PERiprocedural Analgosedation vs. Total IntraVEnous Anaesthesia for Pulsed-Field Ablation (COOPERATIVE-PFA)
- First Posted Date
- 2023-08-28
- Last Posted Date
- 2023-11-28
- Lead Sponsor
- Charles University, Czech Republic
- Target Recruit Count
- 126
- Registration Number
- NCT06013345
- Locations
- 🇨🇿
University Hospital Kralovske Vinohrady, Prague, Czechia
Effects of Remimazolam and Propofol on Anesthesia Induction
- First Posted Date
- 2023-08-24
- Last Posted Date
- 2024-01-25
- Lead Sponsor
- Zheng Guo
- Target Recruit Count
- 80
- Registration Number
- NCT06009055
- Locations
- 🇨🇳
econd of Shanxi Medical University, Taiyuan, Shanxi, China
Drug Development Updates
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