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Tizanidine

Generic Name
Tizanidine
Brand Names
Zanaflex
Drug Type
Small Molecule
Chemical Formula
C9H8ClN5S
CAS Number
51322-75-9
Unique Ingredient Identifier
6AI06C00GW
Background

Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debilitating condition.

Initially approved by the FDA in 1996, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons promoting muscle spasm .

Indication

Tizanidine is indicated for the relief of muscle spasticity, which can interfere with daily activities. The general recommendation is to reserve tizanidine use for periods of time when there is a particular need for relief, as it has a short duration of action .

Associated Conditions
Acute Low Back Pain, Drug Withdrawal Headache, Insomnia, Migraine, Pain, Seizures, Spasticity, Muscle
Associated Therapies
Withdrawal From Addictive Substance; Detoxification
Clinical Trials
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