那他霉素 (Natacyn)

概览

Natamycin is a macrolide antifungal used to treat fungal infections of the eye.

作用机制

Like other polyene antibiotics, Natamycin inhibits fungal growth by binding to sterols. Specifically, Natamycin binds to ergosterol in the plasma membrane, preventing ergosterol-dependent fusion of vacuoles, as well as membrane fusion and fission. This differs from the mechanism of most other polyene antibiotics, which tend to work by altering fungal membrane permeability instead.

适应症

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.

• Fungal blepharitis
• Fungal conjunctivitis
• Fungal infections of the cornea