Theophylline
- Generic Name
- Theophylline
- Brand Names
- Elixophyllin, Elixophylline, Pulmophylline, Quibron-T, Theo-24, Theolair, Uniphyl
- Drug Type
- Small Molecule
- Chemical Formula
- C7H8N4O2
- CAS Number
- 58-55-9
- Unique Ingredient Identifier
- 0I55128JYK
- Background
A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
- Indication
For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.
- Associated Conditions
- Asthma, Bronchitis, Bronchoconstriction, Bronchospasm, Chronic Obstructive Pulmonary Disease (COPD), Chronic bronchial inflammation
- Associated Therapies
- Airway secretion clearance therapy, Bronchodilation
Theophylline in Treating Patients With In Situ, Stage I, or Stage II Chronic Lymphocytic Leukemia
- Conditions
- Leukemia
- First Posted Date
- 2004-07-22
- Last Posted Date
- 2023-06-22
- Lead Sponsor
- Eastern Cooperative Oncology Group
- Registration Number
- NCT00003808
- Locations
- 🇺🇸
Johns Hopkins Oncology Center, Baltimore, Maryland, United States
🇺🇸University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, United States
🇺🇸Kimmel Cancer Center of Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania, United States
NHLBI/NICHD Collaborative Studies of Asthma in Pregnancy
- Conditions
- AsthmaLung Diseases
- First Posted Date
- 1999-10-28
- Last Posted Date
- 2016-07-12
- Lead Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
- Registration Number
- NCT00000578
Drug Development Updates
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