Simvastatin

Generic Name
Simvastatin
Brand Names
Cholib, FloLipid, Simcor, Vytorin, Zocor
Drug Type
Small Molecule
Chemical Formula
C25H38O5
CAS Number
79902-63-9
Unique Ingredient Identifier
AGG2FN16EV
Background

Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of Aspergillus terreus. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liv...

Indication

Simvastatin is indicated for the treatment of hyperlipidemia to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL‑C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C).
...

Associated Conditions
Cardiovascular Events, Diabetes Mellitus, Heterozygous Familial Hypercholesterolemia (HeFH), High Cholesterol, Homozygous Familial Hypercholesterolaemia (HoFH), Mixed Hyperlipidemia, History of coronary heart disease cardiovascular event, History of stroke or other cerebrovascular disease cardiovascular event
Associated Therapies
-
Clinical Trials
Related News

Topical Simvastatin Versus Topical Steroid in Treatment of Alopecia Areata

Phase 4
Not yet recruiting
Conditions
Alopecia Areata
First Posted Date
2024-05-06
Last Posted Date
2024-05-06
Lead Sponsor
Assiut University
Target Recruit Count
54
Registration Number
NCT06399783
Locations
🇪🇬

Assiut university, Assiut, Egypt

Effect of Repeated Oral Doses of Avacopan on the Pharmacokinetics (PK) of a Single Dose of Simvastatin

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
Drug: Avacopan
Drug: Simvastatin
First Posted Date
2024-01-17
Last Posted Date
2024-01-17
Lead Sponsor
Amgen
Target Recruit Count
32
Registration Number
NCT06207682
Locations
🇺🇸

Celerion, Tempe, Arizona, United States

A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese Participants

First Posted Date
2024-01-02
Last Posted Date
2024-07-22
Lead Sponsor
Eli Lilly and Company
Target Recruit Count
50
Registration Number
NCT06186622
Locations
🇺🇸

Fortrea Clinical Research Unit Inc., Dallas, Texas, United States

Effect of Local Application of Simvastatin Versus Bone Powder on Implant Bone Changes

First Posted Date
2023-08-29
Last Posted Date
2023-09-06
Lead Sponsor
British University In Egypt
Target Recruit Count
24
Registration Number
NCT06016218
Locations
🇪🇬

The British University in Egypt, Cairo, Egypt

Simvastatin Versus MTA in Pulpotomy of Immature Permanent Molars

Early Phase 1
Recruiting
Conditions
Pulp Exposure, Dental
Interventions
Drug: Simvastatin
First Posted Date
2023-05-26
Last Posted Date
2023-05-26
Lead Sponsor
Ahmad Elheeny
Target Recruit Count
128
Registration Number
NCT05878158
Locations
🇪🇬

Faculty of Dentistry, Minya, Egypt

Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis

Early Phase 1
Not yet recruiting
Conditions
Recurrent Acute Pancreatitis
Chronic Pancreatitis
Interventions
Drug: Placebo
Drug: Simvastatin
First Posted Date
2023-03-16
Last Posted Date
2024-07-23
Lead Sponsor
Cedars-Sinai Medical Center
Target Recruit Count
90
Registration Number
NCT05771675
Locations
🇺🇸

Marissa Podell, Los Angeles, California, United States

Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy

Phase 4
Completed
Conditions
Periodontitis
Interventions
Drug: Lepidium Sativum
Drug: Simvastatin
First Posted Date
2022-12-20
Last Posted Date
2022-12-20
Lead Sponsor
Ain Shams University
Target Recruit Count
30
Registration Number
NCT05657015
Locations
🇪🇬

Faculty of Dentitry, Ain Shams University, Cairo, Egypt

Efficacy of Combination of Biodentine and Simvastatin as a Pulp Capping Materials in Vital Pulpotomy of Primary Molars

Not Applicable
Completed
Conditions
Pulpitis - Irreversible
Interventions
Drug: Biodentine
Drug: Simvastatin
First Posted Date
2022-10-17
Last Posted Date
2022-10-17
Lead Sponsor
Suez Canal University
Target Recruit Count
20
Registration Number
NCT05582317
Locations
🇪🇬

Faculty of dentistry, Suez canal university, Ismailia, Egypt

A Study of LY3526318 in Healthy Male Japanese Participants

First Posted Date
2022-10-14
Last Posted Date
2023-01-09
Lead Sponsor
Eli Lilly and Company
Registration Number
NCT05580250
Locations
🇯🇵

Souseikai Fukuoka Mirai Hospital, Fukuoka, Japan

Effects of Usage of Simvastatin in Mild to Moderate Traumatic Brain Injury (TBI) Patients. Could it Make a Difference?

Not Applicable
Not yet recruiting
Conditions
Traumatic Brain Injury
Interventions
Drug: Simvastatin
Drug: Placebo drug
First Posted Date
2022-09-23
Last Posted Date
2022-10-10
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT05551871
© Copyright 2024. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy