Simvastatin

Generic Name: Simvastatin

Brand Names: Cholib, FloLipid, Simcor, Vytorin, Zocor

Drug Type: Small Molecule

Chemical Formula: C_₂₅H_₃₈O_₅

CAS Number: 79902-63-9

Unique Ingredient Identifier: AGG2FN16EV

Background: Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of Aspergillus terreus. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liv...

Indication: Simvastatin is indicated for the treatment of hyperlipidemia to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL‑C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C).
...

Associated Conditions: Cardiovascular Events, Diabetes Mellitus, Heterozygous Familial Hypercholesterolemia (HeFH), High Cholesterol, Homozygous Familial Hypercholesterolaemia (HoFH), Mixed Hyperlipidemia, History of coronary heart disease cardiovascular event, History of stroke or other cerebrovascular disease cardiovascular event

Associated Therapies: -

Clinical Trials

LDL Receptor Under Ezetimibe and Simvastatin

Phase 4

Completed

Conditions: Healthy Men

First Posted Date: 2006-04-25

Last Posted Date: 2014-12-03

Lead Sponsor: University of Cologne

Target Recruit Count: 60

Registration Number: NCT00317993

Locations: 🇩🇪
Medizinische Klinik II und Poliklinik für Innere Medizin, Cologne, Germany

Combination of Telmisartan and Simvastatin in the Treatment of Hypertension and Hypercholesterolemia

Phase 3

Completed

Conditions: Hypertension
Dyslipidemias

First Posted Date: 2006-04-20

Last Posted Date: 2013-11-01

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 1695

Registration Number: NCT00316095

Locations: 🇫🇷
ALTI, Angers, France
🇰🇷
Hallym University Sacred Heart Hospital, Kyunggi-do, Korea, Republic of
🇳🇱
Andromed Eindhoven, Eindhoven, Netherlands

and more 20 locations

Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC

Phase 2

Completed

Conditions: Colorectal Cancer
Metastasis

First Posted Date: 2006-04-12

Last Posted Date: 2012-02-02

Lead Sponsor: Samsung Medical Center

Target Recruit Count: 50

Registration Number: NCT00313859

Locations: 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of

Study to Compare the Efficacy and Safety of Pitavastatin and Simvastatin

Phase 3

Completed

Conditions: Hypercholesterolemia
Dyslipidemia

Interventions: Drug: pitavastatin
Drug: simvastatin

First Posted Date: 2006-04-03

Last Posted Date: 2010-03-16

Lead Sponsor: Kowa Research Europe

Target Recruit Count: 355

Registration Number: NCT00309738

Locations: 🇸🇪
Hjarthuset AB, Varberg, Sweden
🇪🇸
Hospital Vall d'Hebron, Barcelona, Spain
🇸🇪
Angelholms Sjukhus, Medicinkliniken, Angelhom, Sweden

and more 29 locations

Study to Compare the Efficacy and Safety of Pitavastatin and Simvastatin

Phase 3

Completed

Conditions: Hypercholesterolemia
Dyslipidemia

Interventions: Drug: Pitavastatin
Drug: Simvastatin

First Posted Date: 2006-04-03

Last Posted Date: 2010-01-12

Lead Sponsor: Kowa Research Europe

Target Recruit Count: 857

Registration Number: NCT00309777

Locations: 🇳🇴
Radhuset Spesialistsenter, Oslo, Norway
🇷🇺
Kemerovo Cardiology Dispensary, Kemerovo, Russian Federation
🇫🇮
Keravan Laakarikeskus, Helsinki, Finland

and more 39 locations

Pioglitazone in Impaired Glucose Tolerance

Phase 4

Withdrawn

Conditions: Glucose Metabolism Disorders

First Posted Date: 2006-03-24

Last Posted Date: 2010-02-02

Lead Sponsor: University of Leipzig

Target Recruit Count: 120

Registration Number: NCT00306826

Locations: 🇩🇪
Praxis Gunter Kässner, Leipzig, Germany
🇩🇪
Praxis Matthias Weissbrodt, Leipzig, Germany
🇩🇪
Praxis Matthias Schreiner, Leipzig, Germany

and more 4 locations

Do HMG CoA Reductase Inhibitors Affect Abeta Levels?

Phase 4

Completed

Conditions: Alzheimer's Disease
Aging

Interventions: Drug: pravastatin
Drug: simvastatin

First Posted Date: 2006-03-16

Last Posted Date: 2010-04-13

Lead Sponsor: Seattle Institute for Biomedical and Clinical Research

Target Recruit Count: 35

Registration Number: NCT00303277

Locations: 🇺🇸
VA Puget Sound Health Care System, Seattle, Washington, United States

Evaluate Safety and Efficacy of ABT-335 in Combination With Simvastatin in Subjects With Multiple Abnormal Lipid Levels in the Blood

Phase 3

Completed

Conditions: Dyslipidemia
Coronary Heart Disease
Mixed Dyslipidemia

Interventions: Drug: ABT-335
Drug: Simvastatin
Drug: Placebo

First Posted Date: 2006-03-09

Last Posted Date: 2009-06-03

Lead Sponsor: Abbott

Target Recruit Count: 657

Registration Number: NCT00300456

Locations: 🇺🇸
Global Medical Information, North Chicago, Illinois, United States

Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis

Phase 4

Conditions: Renal Failure, End Stage
Peritoneal Dialysis

First Posted Date: 2006-02-15

Last Posted Date: 2006-02-16

Lead Sponsor: Federal University of São Paulo

Target Recruit Count: 30

Registration Number: NCT00291863

Locations: 🇧🇷
São Lucas Hospital, Porto Alegre, Rio Grande do Sul, Brazil

Lipid Efficacy and Safety in Participants With Mixed Hyperlipidemia (MK-0524B-024)

Phase 3

Completed

Conditions: Mixed Hyperlipidemia

Interventions: Drug: Atorvastatin
Drug: MK-0524A
Drug: Simvastatin

First Posted Date: 2006-02-10

Last Posted Date: 2018-08-31

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 2340

Registration Number: NCT00289900

Drug Development Updates

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