Simvastatin
- Generic Name
- Simvastatin
- Brand Names
- Cholib, FloLipid, Simcor, Vytorin, Zocor
- Drug Type
- Small Molecule
- Chemical Formula
- C25H38O5
- CAS Number
- 79902-63-9
- Unique Ingredient Identifier
- AGG2FN16EV
- Background
Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of Aspergillus terreus. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liv...
- Indication
Simvastatin is indicated for the treatment of hyperlipidemia to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL‑C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C).
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- Associated Conditions
- Cardiovascular Events, Diabetes Mellitus, Heterozygous Familial Hypercholesterolemia (HeFH), High Cholesterol, Homozygous Familial Hypercholesterolaemia (HoFH), Mixed Hyperlipidemia, History of coronary heart disease cardiovascular event, History of stroke or other cerebrovascular disease cardiovascular event
- Associated Therapies
- -
Simvastatin Therapy in Patients With Dilated Cardiomyopathy.
- First Posted Date
- 2018-12-13
- Last Posted Date
- 2022-08-03
- Lead Sponsor
- National Taiwan University Hospital
- Target Recruit Count
- 8
- Registration Number
- NCT03775070
- Locations
- 🇨🇳
National Taiwan University Hospital, Taipei, Taiwan
The Effect of Simvastatin Combined With Ezetimibe in Patients With Stable Angina and Diabetes
- Conditions
- Interventions
- First Posted Date
- 2018-12-10
- Last Posted Date
- 2018-12-10
- Lead Sponsor
- Chinese PLA General Hospital
- Target Recruit Count
- 240
- Registration Number
- NCT03771053
- Locations
- 🇨🇳
Chinese People's Liberation Army General Hospital, Peking, Beijing, China
Comparative Evaluation Of 1.2% Atorvastatin and 1.2% Simvastatin Gel Local Drug Delivery And Redelivery In Chronic Periodontitis Subjects With Diabetes Mellitus: A Randomized Controlled Clinical Trial.
- Conditions
- Interventions
- First Posted Date
- 2018-11-19
- Last Posted Date
- 2018-11-19
- Target Recruit Count
- 120
- Registration Number
- NCT03745300
- Locations
- 🇮🇳
Department of Periodontics, GDCRI Bangalore, Bangalore, Karnataka, India
Pharmacokinetics of Simvastatin Post Laparoscopic Sleeve Gastrectomy (LSG)
- First Posted Date
- 2018-06-28
- Last Posted Date
- 2022-04-08
- Lead Sponsor
- National University Hospital, Singapore
- Target Recruit Count
- 10
- Registration Number
- NCT03571802
- Locations
- 🇸🇬
National University Hospital, Singapore, Singapore
An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia
- Conditions
- Interventions
- First Posted Date
- 2018-04-27
- Last Posted Date
- 2023-05-06
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 153
- Registration Number
- NCT03510884
- Locations
- 🇪🇸
Investigational Site Number :7240003, Pamplona, Navarra, Spain
🇵🇱Investigational Site Number :6160002, Gdansk, Pomorskie, Poland
🇲🇽Investigational Site Number :4840007, Oaxaca, Mexico
An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia
- First Posted Date
- 2018-04-27
- Last Posted Date
- 2020-12-29
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 18
- Registration Number
- NCT03510715
- Locations
- 🇩🇰
Investigational Site Number 2080001, Viborg, Denmark
🇪🇸Investigational Site Number 7240001, A Coruna, Spain
🇸🇮Investigational Site Number 7050001, Ljubljana, Slovenia
The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast Cancer
- Conditions
- Interventions
- First Posted Date
- 2018-03-06
- Last Posted Date
- 2023-08-01
- Lead Sponsor
- Michael Simon
- Target Recruit Count
- 24
- Registration Number
- NCT03454529
- Locations
- 🇺🇸
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, United States
Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis
- Conditions
- Interventions
- First Posted Date
- 2018-02-05
- Last Posted Date
- 2018-02-06
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 40
- Registration Number
- NCT03419429
Use of Topical Subgingival Application of Simvastatin Gel in the Treatment of Peri-Implant Mucositis
- First Posted Date
- 2018-01-17
- Last Posted Date
- 2018-12-19
- Lead Sponsor
- Ahmed Mohamed Mahrous
- Target Recruit Count
- 46
- Registration Number
- NCT03400475
- Locations
- 🇺🇸
University of Iowa College of Dentistry and Dental Clinics, Iowa City, Iowa, United States
Multiple Sclerosis-Simvastatin Trial 2
- Conditions
- Interventions
- First Posted Date
- 2018-01-02
- Last Posted Date
- 2022-07-07
- Lead Sponsor
- University College, London
- Target Recruit Count
- 964
- Registration Number
- NCT03387670
- Locations
- 🇬🇧
Southmead Hospital, Bristol, United Kingdom
🇬🇧St Luke s Hospital, Bradford, United Kingdom
🇬🇧Kent and Canterbury Hospital, Canterbury, United Kingdom
Drug Development Updates
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