Neratinib

Generic Name
Neratinib
Brand Names
Nerlynx
Drug Type
Small Molecule
Chemical Formula
C30H29ClN6O3
CAS Number
698387-09-6
Unique Ingredient Identifier
JJH94R3PWB
Background

Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer.

Indication

For use as an extended adjuvant treatment in adult patients with early stage HER2-overexpressed/amplified breast cancer, to follow adjuvant trastuzumab-based therapy [FDA Label].

Associated Conditions
Breast Cancer
Associated Therapies
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markets.ft.com
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Puma Biotechnology to Host Conference Call to Discuss Third Quarter Financial Results

Puma Biotechnology will host a conference call on November 7, 2024, following Q3 2024 financial results release. The call will be accessible via phone or webcast on Puma's website, with a replay available for 90 days. Puma is a biopharmaceutical company focusing on cancer care, with products like NERLYNX® and alisertib in development.
defenseworld.net
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Zacks Research Has Positive Outlook for PBYI FY2026 Earnings

Zacks Research raised Puma Biotechnology's FY2026 EPS estimate to $0.72 from $0.69. StockNews.com downgraded PBYI from 'strong-buy' to 'buy'. PBYI opened at $2.88 with a market cap of $138.93M. The company reported a quarterly EPS of ($0.09), beating estimates by $0.01. Director Michael Patrick Miller sold 23,358 shares at $3.49 each. Institutional investors own 61.29% of PBYI.
marketbeat.com
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Zacks Research Analysts Reduce Earnings Estimates for Puma Biotechnology, Inc. (NASDAQ:PBYI)

Zacks Research lowered Puma Biotechnology's FY2025 earnings estimate to $0.19/share from $0.22. StockNews.com downgraded PBYI from "strong-buy" to "buy". PBYI traded up 0.8% at $2.58, with a market cap of $126.55M. Insiders sold 82,263 shares over the last 3 months. Institutional investors own 61.29% of PBYI.
marketbeat.com
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American Century Companies Inc. Purchases 366,653 Shares of Puma Biotechnology, Inc

American Century Companies Inc. increased its stake in Puma Biotechnology by 98.5% in Q2, owning 738,902 shares worth $2,409,000. Other investors also adjusted their holdings, with institutional investors owning 61.29% of the company's stock. Puma Biotechnology's stock opened at $2.58 on Friday, with a market cap of $126.55 million. The company reported a net margin of 4.01% and a return on equity of 18.36% in Q2, beating consensus estimates. Insiders sold 82,263 shares valued at $286,469 over the last quarter, while corporate insiders own 23.70% of the stock. Analysts have varied opinions on PBYI shares, with some downgrading the rating.
defenseworld.net
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Bank of New York Mellon Corp Has $1.01 Million Stake in Puma Biotechnology, Inc. (NASDAQ:PBYI)

Bank of New York Mellon Corp increased its stake in Puma Biotechnology by 63.6% in Q2, owning 308,997 shares worth $1,007,000. Other investors also adjusted their holdings, with Lazard Asset Management LLC raising its stake by 5,129.0% and Jump Financial LLC by 131.7%. Puma Biotechnology reported $47.10 million in revenue for Q2, surpassing estimates, and insiders sold 82,263 shares in the last three months. StockNews.com downgraded Puma Biotechnology from a "strong-buy" to a "buy" rating.
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