Progesterone

Generic Name: Progesterone

Brand Names: Bijuva, Crinone, Endometrin, Prochieve, Prometrium

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₃₀O_₂

CAS Number: 57-83-0

Unique Ingredient Identifier: 4G7DS2Q64Y

Background: Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss . Progesterone is used in various contraceptive preparations to prev...

Indication: Gelatinized capsules

The gelatinized capsules are indicated for use in the prevention of endometrial hyperplasia in non-hysterectomized postmenopausal women who are receiving conjugated estrogens tablets. They are also indicated for use in secondary amenorrhea .

Vaginal gel
...

Associated Conditions: Abnormal Uterine Bleeding, Amenorrhea, Endometrial hyperplasia caused by conjugated estrogen, Moderate to Severe Vasomotor Symptoms, Pregnancy, Secondary Amenorrhea, Recurrent spontaneous preterm birth

Associated Therapies: Assisted Reproductive Technology therapy

Clinical Trials

Compare the Difference of P4 Concentration in Serum and Endometrium After Vaginal and IM P Administration

Phase 1

Completed

Conditions: Postmenopausal Endometrium

Interventions: Drug: Crinone 8%
Drug: Progesterone

First Posted Date: 2010-01-27

Last Posted Date: 2012-04-03

Lead Sponsor: Peking Union Medical College Hospital

Target Recruit Count: 51

Registration Number: NCT01057511

Locations: 🇨🇳
Peking Union Medical College Hospital, Beijing, China

Luteal Support and Intrauterine Insemination (IUI) With Clomiphene Citrate

Not Applicable

Completed

Conditions: Infertility

Interventions: Drug: micronized progesterone

First Posted Date: 2010-01-12

Last Posted Date: 2013-07-03

Lead Sponsor: Universitair Ziekenhuis Brussel

Target Recruit Count: 300

Registration Number: NCT01046708

Prophylactic Administration of Natural Progesterone in the Prevention of Preterm Delivery in Twin Pregnancies

Phase 4

Completed

Conditions: Preterm Delivery

Interventions: Drug: placebo
Drug: progesterone

First Posted Date: 2009-12-14

Last Posted Date: 2014-12-04

Lead Sponsor: University of Sao Paulo

Target Recruit Count: 390

Registration Number: NCT01031017

Locations: 🇧🇷
Hospital das Clinicas, São Paulo, SP, Brazil

Comparison of Transdermal and Oral Estrogens in Adolescent Girls With Ovarian Failure

Not Applicable

Completed

Conditions: Ovarian Failure, Premature

Interventions: Drug: 17Beta Estradiol - transdermal
Drug: 17beta Estradiol
Drug: Conjugated estrogens
Drug: Progesterone, micronized

First Posted Date: 2009-12-02

Last Posted Date: 2017-01-20

Lead Sponsor: Stanford University

Target Recruit Count: 20

Registration Number: NCT01023178

Locations: 🇺🇸
Stanford University School of Medicine, Stanford, California, United States

Progesterone for Maintenance Tocolysis: A Randomized Placebo Controlled Trial

Phase 2

Terminated

Conditions: Pregnancy Complications

Interventions: Drug: Progesterone
Drug: Polyethylene glycol&hydrogenated vegetable oil.

First Posted Date: 2009-07-24

Last Posted Date: 2017-03-16

Lead Sponsor: Stanford University

Target Recruit Count: 7

Registration Number: NCT00946088

Locations: 🇺🇸
Stanford University School of Medicine, Stanford, California, United States

PP13 and Doppler Study to Predict Preeclampsia

Phase 2

Conditions: Preeclampsia

Interventions: Drug: No Drug
Drug: Low molecular weight Heparin
Drug: Progesterone

First Posted Date: 2009-06-25

Last Posted Date: 2009-06-25

Lead Sponsor: Ben-Gurion University of the Negev

Target Recruit Count: 1000

Registration Number: NCT00928213

Locations: 🇮🇱
Soroka Medical Center, Ben Gurion University, Beer-Sheva, Israel

Efficacy and Tolerability Study of Progesterone Vaginal Tablets (Endometrin®) in Menopausal Women Treated by Estrogen

Phase 2

Conditions: Endometrial Hyperplasia
Endometrial Cancer

Interventions: Drug: activella
Drug: progesterone

First Posted Date: 2009-06-12

Last Posted Date: 2009-06-12

Lead Sponsor: Rabin Medical Center

Target Recruit Count: 60

Registration Number: NCT00919919

Locations: 🇮🇱
Rabin Medical Center Beilinson Hospital, Petach Tikva, Israel

Subcutaneous Progesterone Versus Vaginal Progesterone Tablets for Luteal Phase Support in In Vitro Fertilization (IVF)

Phase 3

Completed

Conditions: In Vitro Fertilization

Interventions: Drug: Progesterone

First Posted Date: 2009-01-23

Last Posted Date: 2013-01-31

Lead Sponsor: IBSA Institut Biochimique SA

Target Recruit Count: 800

Registration Number: NCT00828191

Locations: 🇺🇸
Idaho Center for Reproductive Medicine, Boise, Idaho, United States
🇺🇸
Center for Assisted Reproduction, Bedford, Texas, United States
🇺🇸
Seattle Reproductive Medicine, Seattle, Washington, United States

and more 5 locations

Subcutaneous Progesterone Versus Vaginal Progesterone Gel for Luteal Phase Support in Patients Undergoing In-Vitro Fertilization (IVF)

Phase 3

Completed

Conditions: In Vitro Fertilization

Interventions: Drug: Progesterone

First Posted Date: 2009-01-23

Last Posted Date: 2013-01-31

Lead Sponsor: IBSA Institut Biochimique SA

Target Recruit Count: 683

Registration Number: NCT00827983

Locations: 🇨🇭
IIRM SA, Sorengo, Ticino, Switzerland
🇨🇭
Universitätsfrauenklinik Basel, Basel, Switzerland
🇭🇺
First Dept. Obstetric and Gynaecology, Semmelweiss University Faculty of Medicine, Budapest, Hungary

and more 11 locations

Progesterone for the Treatment of Traumatic Brain Injury III

Phase 3

Terminated

Conditions: Traumatic Brain Injury

Interventions: Drug: Placebo
Drug: Progesterone

First Posted Date: 2009-01-15

Last Posted Date: 2016-01-20

Lead Sponsor: David Wright

Target Recruit Count: 882

Registration Number: NCT00822900

Locations: 🇺🇸
North Memorial Hospital, Robbinsdale, Minnesota, United States
🇺🇸
Regional Medical Center-San Jose, San Jose, California, United States
🇺🇸
Grady Memorial Hospital, Atlanta, Georgia, United States

and more 33 locations

Drug Development Updates

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