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Oxygen

Generic Name
Oxygen
Brand Names
Alnox, Ez-OX, Heliox, Oxygen, Southern Medical
Drug Type
Small Molecule
Chemical Formula
O2
CAS Number
7782-44-7
Unique Ingredient Identifier
S88TT14065
Background

Oxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing blood flow resistance in the diseased lung, leading to decreased cardiovascular workload in an attempt to oxygenate the lungs. Oxygen therapy is used to treat emphysema, pneumonia, some heart disorders (congestive heart failure), some disorders that cause increased pulmonary artery pressure, and any disease that impairs the body's ability to take up and use gaseous oxygen. Higher level of oxygen than ambient air (hyperoxia) can be introduced under normobaric or hyperbaric conditions.

Indication

Oxygen therapy in clinical settings is used across diverse specialties, including various types of anoxia, hypoxia or dyspnea and any other disease states and conditions that reduce the efficiency of gas exchange and oxygen consumption such as respiratory illnesses, trauma, poisonings and drug overdoses. Oxygen therapy tries to achieve hyperoxia to reduce the extent of hypoxia-induced tissue damage and malfunction.

Associated Conditions
Anemia, Cancer, Hypoxemia, Hypoxia, Migraine, Polycythemia, Pulmonary Hypertension (PH), Respiratory Disorders, Sleep Apnea
Associated Therapies
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Is Peri-operative Hyperoxemia a Risk Factor for Postoperative Complications?

Phase 3
Completed
Conditions
Vascular Disease
Interventions
Drug: Oxygen
Other: Air
First Posted Date
2015-09-29
Last Posted Date
2021-03-04
Lead Sponsor
Örebro University, Sweden
Target Recruit Count
184
Registration Number
NCT02562781
Locations
🇸🇪

University Hospital, Örebro, Sweden

🇸🇪

Örebro University Hospital, Örebro, Sweden

rEduction of oXygen After Cardiac arresT: a Pilot Study

Phase 2
Completed
Conditions
Heart Arrest
Interventions
First Posted Date
2015-07-15
Last Posted Date
2017-09-07
Lead Sponsor
Monash University
Target Recruit Count
59
Registration Number
NCT02499042
Locations
🇦🇺

Ambulance Victoria, Melbourne, Victoria, Australia

🇦🇺

SA Ambulance Service, Adelaide, South Australia, Australia

Predictors of Opioid-Induced Respiratory Depression (OIRD)

Phase 1
Completed
Conditions
Respiratory Depression
Interventions
First Posted Date
2015-06-16
Last Posted Date
2020-03-10
Lead Sponsor
Duke University
Target Recruit Count
30
Registration Number
NCT02473354
Locations
🇺🇸

Duke University Health Systems, Durham, North Carolina, United States

Reduction of Venous Emboli Load After Breathing Normobaric Oxygen Compared to Air

Phase 2
Completed
Conditions
Decompression Sickness
Inflammation
Endothelial Dysfunction
Diving Medicine
Central Nervous Injury
Hyperbaric
Interventions
Other: Air
Drug: Oxygen
First Posted Date
2015-06-11
Last Posted Date
2022-05-27
Lead Sponsor
Göteborg University
Target Recruit Count
48
Registration Number
NCT02468752
Locations
🇸🇪

Kungliga Tekniska Högskolan, Stockholm, Sweden

🇸🇪

Sahlgrenska University Hospital, Gothenburg, Sweden

Oxygen Therapy During Acute Respiratory Failure in Immuno-compromised Patients

Phase 3
Completed
Conditions
Acute Respiratory Failure
Immunocompromised Host
High Flow Oxygen Cannula
Interventions
Device: Venturi mask
Device: High Flow Nasal Canula (HFNC)
Drug: Oxygen
First Posted Date
2015-04-23
Last Posted Date
2016-04-18
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
100
Registration Number
NCT02424773

Adjunctive Nitrous Oxide During Emergency Department Propofol Sedation in Adults

Not Applicable
Completed
Conditions
Joint Dislocation
Perianal Abscess
Abscess
Interventions
Drug: Nitrous Oxide arm
Drug: Propofol
Drug: Oxygen
First Posted Date
2015-04-08
Last Posted Date
2020-04-08
Lead Sponsor
Albert Einstein Healthcare Network
Target Recruit Count
43
Registration Number
NCT02410707
Locations
🇺🇸

Albert Einstein Medical Center, Philadelphia, Pennsylvania, United States

Trial of Hyperoxic O2 Therapy vs. Normoxic O2 Therapy in Sepsis

Phase 4
Completed
Conditions
Sepsis
Interventions
First Posted Date
2015-03-04
Last Posted Date
2017-09-19
Lead Sponsor
University Hospital Plymouth NHS Trust
Target Recruit Count
50
Registration Number
NCT02378545
Locations
🇬🇧

Plymouth Hospitals NHS Trust, Plymouth, Devon, United Kingdom

Hyperbaric VO2max Study

Phase 2
Terminated
Conditions
Exercise Training
Interventions
Procedure: Normoxic, normobaric, interval exercise training
Procedure: Hyperoxic hyperbaric interval exercise training
Drug: Oxygen
First Posted Date
2015-02-05
Last Posted Date
2017-05-17
Lead Sponsor
Duke University
Target Recruit Count
25
Registration Number
NCT02356900
Locations
🇺🇸

Duke University Hospital, Durham, North Carolina, United States

Optimal Oxygenation in the Intensive Care Unit

Phase 4
Completed
Conditions
Systemic Inflammatory Response Syndrome
Interventions
First Posted Date
2014-12-22
Last Posted Date
2021-04-19
Lead Sponsor
Amsterdam UMC, location VUmc
Target Recruit Count
400
Registration Number
NCT02321072
Locations
🇳🇱

VU University Medical Center, Amsterdam, Netherlands

Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction by Biomarkers

Phase 3
Completed
Conditions
ST Elevation (STEMI) Myocardial Infarction
Non-ST Elevation (NSTEMI) Myocardial Infarction
Acute Myocardial Infarction (AMI)
Acute Coronary Syndrome (ACS)
Angina, Unstable
Ischemic Reperfusion Injury
Interventions
First Posted Date
2014-11-13
Last Posted Date
2017-12-11
Lead Sponsor
Karolinska Institutet
Target Recruit Count
175
Registration Number
NCT02290080
Locations
🇸🇪

Södersjukhuset, Stockholm, Sweden

🇸🇪

Linköping University Hospital, Linköping, Sweden

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