Anacaulase
- Generic Name
- Anacaulase
- Brand Names
- NexoBrid
- Drug Type
- Biotech
Overview
Anacaulase (anacaulase-bcdb) is a mixture of proteolytic enzymes extracted from the stems of pineapple plants (Ananas comosus [L.] Merr.). It is mostly composed (80-95% w/w) of proteins such as stem bromelain, ananain, jacalin-like lectin, bromelain inhibitors, and phytocystatin inhibitor, as well as saccharides, as both free monosaccharides and the N-linked glycan of stem bromelain and small molecule metabolites. Anacaulase is indicated for eschar removal in patients with deep partial thickness and/or full-thickness thermal burns. Removing eschar (a process also known as debridement) through surgical procedures can lead to significant trauma, major blood and heat loss and adjacent tissue damage. They also require specialized surgical personnel and facilities, and autologous skin grafting may be needed. Therefore, enzymatic alternatives such as anacaulase can lead to better clinical outcomes. The EMA approved the use of anacaulase in 2013, and in January 2023, anacaulase received FDA approval.
Background
Anacaulase (anacaulase-bcdb) is a mixture of proteolytic enzymes extracted from the stems of pineapple plants (Ananas comosus [L.] Merr.). It is mostly composed (80-95% w/w) of proteins such as stem bromelain, ananain, jacalin-like lectin, bromelain inhibitors, and phytocystatin inhibitor, as well as saccharides, as both free monosaccharides and the N-linked glycan of stem bromelain and small molecule metabolites. Anacaulase is indicated for eschar removal in patients with deep partial thickness and/or full-thickness thermal burns. Removing eschar (a process also known as debridement) through surgical procedures can lead to significant trauma, major blood and heat loss and adjacent tissue damage. They also require specialized surgical personnel and facilities, and autologous skin grafting may be needed. Therefore, enzymatic alternatives such as anacaulase can lead to better clinical outcomes. The EMA approved the use of anacaulase in 2013, and in January 2023, anacaulase received FDA approval.
Indication
Anacaulase is indicated for eschar removal in adults with deep partial thickness and/or full-thickness thermal burns.
Associated Conditions
No associated conditions information available.
Clinical Trials
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No clinical trials found
No clinical trials found for this drug
FDA Approved Products
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No FDA products found
No FDA products found for this drug
EMA Approved Products
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No EMA products found
No EMA products found for this drug
HSA Approved Products
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No HSA products found
No HSA products found for this drug
NMPA Approved Products
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No NMPA products found
No NMPA products found for this drug
PPB Approved Products
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No PPB products found for this drug
TGA Approved Products
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No TGA products found
No TGA products found for this drug