Tramadol

Generic Name: Tramadol

Brand Names: Conzip, Durela, Qdolo, Ralivia, Ryzolt, Seglentis, Tridural, Ultracet, Ultram, Zytram

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₂₅NO_₂

CAS Number: 27203-92-5

Unique Ingredient Identifier: 39J1LGJ30J

Background: Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is consider...

Indication: Tramadol is approved for the management of moderate to severe pain in adults.

Tramadol is also used off-label in the treatment of premature ejaculation.

Associated Conditions: Acute Pain, Premature Ejaculation, Severe Pain, Acute, moderate, severe Pain, Moderate Pain

Associated Therapies: -

Clinical Trials

Postoperative Tramadol/Gabapentin/Ibuprofen Versus Tramadol/Placebo/Ibuprofen

Phase 4

Terminated

Conditions: Pain

Interventions: Drug: gabapentin
Drug: Tramadol
Drug: Placebo
Drug: Ibuprofen

First Posted Date: 2014-03-04

Last Posted Date: 2017-02-09

Lead Sponsor: Children's Hospitals and Clinics of Minnesota

Target Recruit Count: 64

Registration Number: NCT02076893

Locations: 🇺🇸
Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota, United States

Tramadol Versus Celecoxib for Reducing Pain in Outpatient Hysteroscopy

Phase 2

Completed

Conditions: Pain

Interventions: Drug: Placebo
Drug: Celecoxib
Drug: Tramadol

First Posted Date: 2014-02-25

Last Posted Date: 2015-01-05

Lead Sponsor: Cairo University

Target Recruit Count: 210

Registration Number: NCT02071303

Locations: 🇪🇬
Cairo University Hospitals, Cairo, Egypt

Evaluation of the Role of Tramadol 50mg as an Analgesic During Outpatient Hysteroscopy

Phase 2

Completed

Conditions: Pain

Interventions: Drug: Placebo
Drug: Tramadol

First Posted Date: 2014-02-21

Last Posted Date: 2015-04-06

Lead Sponsor: Cairo University

Target Recruit Count: 140

Registration Number: NCT02068209

Locations: 🇪🇬
Cairo University Hospitals, Cairo, Egypt

Tamadol Wound Infiltration in Children Under Inguinal Hernioplasty

Phase 4

Completed

Conditions: Children
Inguinal Hernia

Interventions: Drug: tramadol
Drug: 0.9% saline

First Posted Date: 2013-09-17

Last Posted Date: 2013-09-17

Lead Sponsor: Federal University of São Paulo

Target Recruit Count: 40

Registration Number: NCT01943760

Locations: 🇧🇷
São Paulo Hospital, São Paulo, Brazil

Tramadol for Labour Analgesia in Low Risk Primiparous Women

Phase 3

Completed

Conditions: Pain During Labour

Interventions: Drug: Placebo
Drug: Tramadol

First Posted Date: 2013-07-01

Last Posted Date: 2013-07-09

Lead Sponsor: Saint Thomas Hospital, Panama

Target Recruit Count: 100

Registration Number: NCT01889979

Locations: 🇵🇦
Saint Thomas Maternity Hospital, Panama, Panama

DPNB for Prevention of CRDB

Phase 3

Completed

Conditions: Indwelling Urinary Catheter
Male Patients
General Anesthesia

Interventions: Drug: Tramadol
Procedure: DPNB

First Posted Date: 2012-11-02

Last Posted Date: 2018-09-17

Lead Sponsor: West China Hospital

Target Recruit Count: 58

Registration Number: NCT01721031

Locations: 🇨🇳
West China Hospital, Sichuan University, Chengdu, Sichuan, China

Combined Behavioral and Analgesic Trial for Fibromyalgia

Phase 3

Completed

Conditions: Fibromyalgia

Interventions: Drug: Tramadol
Drug: Placebo
Behavioral: Cognitive Behavior Therapy for FM
Behavioral: Health Education

First Posted Date: 2012-05-15

Last Posted Date: 2019-06-26

Lead Sponsor: University of Washington

Target Recruit Count: 134

Registration Number: NCT01598753

Locations: 🇺🇸
University of Rochester, Rochester, New York, United States
🇺🇸
University of Washington, Seattle, Washington, United States

Intraoperative Use of Dexketoprofen Trometamol, Pethidine Hcl, Tramadol Hcl and Their Combinations for Postoperative Pain Management in Laparoscopic Nissen Fundoplication

Phase 4

Conditions: Laparoscopic Nissen Fundoplication

Interventions: Drug: dexketoprofen trometamol
Drug: pethidine hydrochloride
Drug: dexketoprofen trometamol + tramadol hydrochloride
Drug: dexketoprofen trometamol + pethidine hydrochloride
Drug: vitamin c
Drug: tramadol hydrochloride

First Posted Date: 2012-03-20

Last Posted Date: 2012-03-23

Lead Sponsor: Kavaklıdere Umut Hospital

Target Recruit Count: 72

Registration Number: NCT01558622

Locations: 🇹🇷
Kavaklidere Umut Hospital, Ankara, Turkey

Perioperative Electroacupuncture on Postoperative Analgesia in Prostatectomy

Phase 4

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Tramadol
Drug: Ketamine
Drug: Morphine
Procedure: sedation
Procedure: rescue analgesia
Drug: Parecoxib
Drug: paracetamol

First Posted Date: 2012-02-06

Last Posted Date: 2014-02-21

Lead Sponsor: G.Gennimatas General Hospital

Target Recruit Count: 70

Registration Number: NCT01526525

Locations: 🇬🇷
G.Gennimatas GENERAL HOSPITAL OF THESSALONIKI, Thessaloniki, Greece

Tramadol Extended-Release (ER) for Posttraumatic Stress Disorder (PTSD)

Phase 4

Completed

Conditions: Post-Traumatic Stress Disorder

Interventions: Drug: Placebo
Drug: Tramadol

First Posted Date: 2012-01-25

Last Posted Date: 2022-08-31

Lead Sponsor: INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium

Target Recruit Count: 40

Registration Number: NCT01517711

Locations: 🇺🇸
Cincinnati VA Medical Center, Cincinnati, Ohio, United States

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