Gentamicin

Generic Name: Gentamicin

Brand Names: Gentak, Pred-G, Valisone-G

Drug Type: Small Molecule

Chemical Formula: C_₆₀H_₁₂₃N_₁₅O_₂₁

CAS Number: 1403-66-3

Unique Ingredient Identifier: T6Z9V48IKG

Background: Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from Micromonospora purpurea in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability. Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment ...

Indication: 1.本品适用于敏感铜绿假单胞菌、变形杆菌（吲哚阳性和阴性）属、大肠埃希菌、克雷伯菌属、肠杆菌属、沙雷菌属、柠檬酸杆菌属以及葡萄球菌属（不包括耐甲氧西林菌株）所致的严重感染；临床上本品常与β内酰胺类或其他抗菌药物联合应用。本品与青霉素G（或氨苄西林）联合应用治疗肠球菌感染；

2.本品用于铜绿假单胞菌或葡萄球菌属所致的严重中枢神经系统感染（如脑膜炎、脑室炎）时，可同时用本品鞘内注射作为辅助治疗；

3.本品不适用于单纯性尿路感染初治，除非病原菌对其他毒性较低的抗菌药物不敏感，本品对链球菌属中多数菌种（尤其D组）、肺炎链球菌和厌氧菌（如拟杆菌属或梭状芽孢杆菌属）无效；

4.本品口服可用于肠道感染或结肠手术前准备，也可用本品肌注合并克林霉素或甲硝唑以减少结肠手术后感染率。
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Associated Conditions: Allergic Conjunctivitis (AC), Bacterial Conjunctivitis, Bacterial Infections, Bacterial Keratitis, Bacterial Peritonitis, Bacterial dacryocystitis, Blepharoconjunctivitis, Central Nervous System Infections, Corneal infection, Dermatitis infected, Ecthyma, Eczematous dermatitis infected, Folliculitis, Furunculosis, Gram-negative enteric bacilli neonatal sepsis, Impetigo contagious, Inflammation, Keratoconjunctivitis, Meibomianitis, Meningitis, Bacterial, Ocular Inflammation, Pustular Psoriasis (PP), Pustular acne, Pyoderma Gangrenosum, Seborrheic Dermatitis, Septicemia gram-negative, Skin Infections, Skin and Subcutaneous Tissue Bacterial Infections, Sycosis barbae, Bacterial blepharitis, Bacterial corneal ulcers, Bacterial skin infections, Complicated Respiratory tract infection bacterial, Complicated Urinary Tract Infection caused by susceptible bacteria, Corticosteroid-responsive dermatoses, Ocular bacterial infections, Severe Endocarditis enterococcal, Severe Infection Pseudomonas aeruginosa, Severe Staphylococcal infection

Associated Therapies: -

Clinical Trials

NIS-Seq enables cell-type-agnostic optical perturbation screening

CROPseq-iT7 backbone and Brunello library were cloned, tissue culture conditions for various cell lines were established, and library transduction and quality control were performed. NIS-Seq perturbation screens were conducted, and imaging and image analysis were detailed. Single-gene perturbation cell lines were generated for validation, and primary human macrophages were differentiated, transduced, and nucleofected. Inflammasome stimulation and human epidermal sheet preparation, transduction, and sequencing were also described. Zero-knowledge image analysis using deep learning was performed, and ethics statements were included.

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