Cobicistat
- Generic Name
- Cobicistat
- Brand Names
- Evotaz, Genvoya, Prezcobix, Rezolsta, Stribild, Tybost
- Drug Type
- Small Molecule
- Chemical Formula
- C40H53N7O5S2
- CAS Number
- 1004316-88-4
- Unique Ingredient Identifier
- LW2E03M5PG
- Background
Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic exposure of coadministered agents that ar...
- Indication
Cobicistat is a CYP3A inhibitor indicated to increase systemic exposure of atazanavir or darunavir (once daily dosing regimen) in combination with other antiretroviral agents in the treatment of HIV-1 infection. It is not interchangeable with ritonavir to increase systemic exposure of darunavir 600 mg twice daily, fosamprenavir, saquinavir, or tipranavir due...
- Associated Conditions
- Human Immunodeficiency Virus (HIV) Infections, Human Immunodeficiency Virus Type 1 (HIV-1) Infection
- Associated Therapies
- -
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