聚苯乙烯磺酸钙 (Trovan)

概览

Trovafloxacin is an antibiotic used to treat gonorrhea and chlamydia.

作用机制

Trovafloxacin is a fluoronaphthyridone related to the fluoroquinolones with in vitro activity against a wide range of gram-negative and gram-positive aerobic and anaerobic microorganisms. The bactericidal action of trovafloxacin results from inhibition of DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription, and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.

适应症

For treatment of infections caused by susceptible strains of the designated microorganisms in uncomplicated urethral gonorrhea in males and endocervical and rectal gonorrhea in females caused by Neisseria gonorrhoeae as well as non gonoccocal urethritis and cervicitis due to Chlamydia trachomatis.

• Community Acquired Pneumonia (CAP)
• Complicated Intra-Abdominal Infections (cIAIs)
• Complicated Skin and Skin Structure Infection
• Nosocomial Pneumonia
• Pelvic Infections