Overview
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Indication
For the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics.
Associated Conditions
- Bacterial Infections
- Chronic Gouty Arthritis
- Elevated Serum Uric Acid
- Gout Chronic
- Hyperuricemia
- Infection
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2021/09/16 | Phase 1 | Completed | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | ||
2021/06/25 | Phase 2 | Recruiting | |||
2021/02/10 | N/A | Active, not recruiting | |||
2020/09/16 | Phase 2 | Recruiting | |||
2019/05/29 | Phase 4 | Completed | |||
2019/05/03 | Phase 1 | Completed | |||
2019/01/11 | Phase 1 | Completed | |||
2018/03/15 | Phase 1 | Completed | |||
2017/10/11 | Phase 1 | Completed | |||
2017/09/28 | Phase 1 | Completed | Theracos |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Rising Pharma Holdings, Inc. | 16571-831 | ORAL | 500 mg in 1 1 | 11/28/2023 | |
| Aphena Pharma Solutions - Tennessee, LLC | 43353-839 | ORAL | 500 mg in 1 1 | 5/28/2014 | |
| Medstone Pharma LLC | 71626-999 | ORAL | 500 mg in 1 1 | 2/12/2021 | |
| Quality Care Products, LLC | 83008-020 | ORAL | 500 mg in 1 1 | 5/24/2023 | |
| Westminster Pharmaceuticals, LLC | 69367-154 | ORAL | 500 mg in 1 1 | 7/27/2016 |
EMA Drug Approvals
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Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
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Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
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Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
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Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
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