Lisinopril
- Generic Name
- Lisinopril
- Brand Names
- Prinivil, Qbrelis, Zestoretic, Zestril
- Drug Type
- Small Molecule
- Chemical Formula
- C21H31N3O5
- CAS Number
- 76547-98-3
- Unique Ingredient Identifier
- 7Q3P4BS2FD
- Background
Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction. Lisinopril and captopril are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system. ACEIs are commonly used as a first line therap...
- Indication
Lisinopril is indicated for the treatment of acute myocardial infarction, hypertension in patients ≥6 years, and as an adjunct therapy for heart failure. A combination product with hydrochlorothiazide is indicated for the treatment of hypertension.
- Associated Conditions
- Acute Myocardial Infarction (AMI), Cardiovascular Events, Congestive Heart Failure (CHF), Diabetic Nephropathy, Hypertension, Migraine
- Associated Therapies
- -
Comparison of Optimal Hypertension Regimens
- Conditions
- Interventions
- First Posted Date
- 2016-07-28
- Last Posted Date
- 2021-07-28
- Target Recruit Count
- 1320
- Registration Number
- NCT02847338
- Locations
- 🇬🇧
Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom
🇬🇧University Hospital Llandough, Cardiff, United Kingdom
🇬🇧Queen Elizabeth Hospital, Birmingham, United Kingdom
ACE-inhibitors in Extracapillary Glomerulonephritis
- First Posted Date
- 2016-02-15
- Last Posted Date
- 2018-04-06
- Lead Sponsor
- Monia Lorini
- Target Recruit Count
- 22
- Registration Number
- NCT02682459
- Locations
- 🇮🇹
ASST Papa Giovanni XXIII, Bergamo, Italy
🇮🇹Centro di Ricerche Cliniche per le Malattie Rare Aldo e Cele Daccò, Ranica, Bergamo, Italy
Study of the Effects of ITCA 650 on Gastric Emptying and Interaction of ITCA 650 on 4 Commonly Studied Drugs
- Conditions
- Interventions
- First Posted Date
- 2015-12-30
- Last Posted Date
- 2017-01-27
- Lead Sponsor
- Intarcia Therapeutics
- Target Recruit Count
- 33
- Registration Number
- NCT02641899
- Locations
- 🇺🇸
Quintiles, Overland Park, Kansas, United States
Evaluation of Periop Biochemical Stress Factors in Craniotomy Neurosurgical Procedure With Respect to Preop Hypertension
- Conditions
- Interventions
- First Posted Date
- 2015-05-12
- Last Posted Date
- 2017-02-08
- Lead Sponsor
- Milton S. Hershey Medical Center
- Target Recruit Count
- 85
- Registration Number
- NCT02441842
Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension
- Conditions
- Interventions
- First Posted Date
- 2015-04-09
- Last Posted Date
- 2018-11-15
- Target Recruit Count
- 42
- Registration Number
- NCT02412761
- Locations
- 🇺🇸
University of Texas at Houston Medical School; Pediatric Nephrology and Hypertension Clinics, Houston, Texas, United States
Modulation of Heme Oxygenase 1 by Nizatidine and Lisinopril in Healthy Subjects
- First Posted Date
- 2014-09-05
- Last Posted Date
- 2015-04-30
- Lead Sponsor
- Adil Bharucha
- Target Recruit Count
- 24
- Registration Number
- NCT02232308
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
🇺🇸Mayo Clinic, Rochester, Minnesota, United States
A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Lisinopril and Warfarin in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2014-02-25
- Last Posted Date
- 2020-02-17
- Lead Sponsor
- Novo Nordisk A/S
- Target Recruit Count
- 52
- Registration Number
- NCT02070510
- Locations
- 🇩🇪
Novo Nordisk Investigational Site, Berlin, Germany
Non-invasive Haemodynamic Assessment in Hypertension
- Conditions
- Interventions
- First Posted Date
- 2013-11-27
- Last Posted Date
- 2018-03-13
- Target Recruit Count
- 144
- Registration Number
- NCT01996085
- Locations
- 🇵🇱
Military Institute of Medicine, Warsaw, Mazovia, Poland
CAndesartan vs LIsinopril Effects on the BRain
- Conditions
- Interventions
- First Posted Date
- 2013-11-14
- Last Posted Date
- 2021-02-21
- Lead Sponsor
- Emory University
- Target Recruit Count
- 176
- Registration Number
- NCT01984164
- Locations
- 🇺🇸
Emory Univeristy, Atlanta, Georgia, United States
Cardiomyopathy in DMD: Lisinopril vs. Losartan
- Conditions
- Interventions
- First Posted Date
- 2013-11-13
- Last Posted Date
- 2017-03-21
- Lead Sponsor
- Nationwide Children's Hospital
- Target Recruit Count
- 23
- Registration Number
- NCT01982695
- Locations
- 🇺🇸
University of California Davis, Davis, California, United States
🇺🇸Boston Children's Hospital, Boston, Massachusetts, United States
🇺🇸St. Louis Children's Hospital, St. Louise, Missouri, United States
Drug Development Updates
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