TP-3654
- Generic Name
- TP-3654
- Brand Names
- Relyvrio
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25F3N4O
- CAS Number
- 1361951-15-6
- Unique Ingredient Identifier
- EOB0N7BOY4
- Background
Tauroursodeoxycholic acid, also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. It is a taurine conjugate of ursodeoxycholic acid with comparable therapeutic efficacy and safety, but a much higher hydrophilicity. Normally, hydrophilic bile acids regulates hydrophobic bile acids and their cytotoxic effects. Tauroursodeoxycholic acid can reduce the absorption of cholesterol in the small intestine, thereby reducing the body's intake of dietary cholesterol and the body cholesterol content.
Tauroursodeoxycholic acid is currently used in Europe to treat and prevent gallstones as a bile acid derivative. Due to a range of its molecular properties - namely its anti-apoptotic effects - tauroursodeoxycholic acid has been examined in inflammatory metabolic diseases and neurodegenerative diseases.
- Indication
Tauroursodeoxycholic acid is used to prevent and treat gallstone formation.
Tauroursodeoxycholic acid is used in combination with phenylbutyric acid to treat amyotrophic lateral sclerosis (ALS) in adults.
- Associated Conditions
- Amyotrophic Lateral Sclerosis (ALS), Gallstones
- Associated Therapies
- -
Study of Tauroursodeoxycholic Acid for Hepatobiliary Disease in Cystic Fibrosis
- Conditions
- First Posted Date
- 1999-10-19
- Last Posted Date
- 2015-03-25
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Target Recruit Count
- 39
- Registration Number
- NCT00004441
- Locations
- 🇺🇸
Children's Hospital of Denver, Denver, Colorado, United States
🇺🇸Children's Hospital Medical Center - Cincinnati, Cincinnati, Ohio, United States
🇮🇹University of Milan, Milan, Italy
Randomized Study of Tauroursodeoxycholic Acid in Prophylactic Therapy of Total Parenteral Nutrition Associated Cholestasis in Infants
- Conditions
- First Posted Date
- 1999-10-19
- Last Posted Date
- 2015-03-25
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Target Recruit Count
- 50
- Registration Number
- NCT00004410
- Locations
- 🇺🇸
Children's Hospitals and Clinics - Minneapolis, Minneapolis, Minnesota, United States
🇺🇸Children's Hospital Medical Center - Cincinnati, Cincinnati, Ohio, United States
🇺🇸University of Mississippi Medical Center, Jackson, Mississippi, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.