MedPath

Amantadine

Generic Name
Amantadine
Brand Names
Gocovri, Osmolex
Drug Type
Small Molecule
Chemical Formula
C10H17N
CAS Number
768-94-5
Unique Ingredient Identifier
BF4C9Z1J53

Overview

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

Background

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

Indication

For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.

Associated Conditions

  • Dyskinesia
  • Extrapyramidal disorder caused by neuroleptic drugs without Tardive dyskinesia
  • Influenza A Virus Infection
  • Parkinson's Disease (PD)
  • Parkinson's Disease With Wearing-off Motor Fluctuations
  • Parkinsonism

FDA Approved Products

OSMOLEX ER
Manufacturer:Adamas Pharma, LLC
Route:ORAL
Strength:193 mg in 1 1
Approved: 2024/02/08
NDC:70482-076
Amantadine HCl
Manufacturer:Rebel Distributors Corp.
Route:ORAL
Strength:100 mg in 1 1
Approved: 2010/01/06
NDC:21695-564
Amantadine Hydrochloride
Manufacturer:Upsher-Smith Laboratories, LLC
Route:ORAL
Strength:100 mg in 1 1
Approved: 2023/05/12
NDC:0832-0111
AMANTADINE HYDROCHLORIDE
Manufacturer:Apnar Pharma LP
Route:ORAL
Strength:100 mg in 1 1
Approved: 2022/01/03
NDC:24689-112
Amantadine HCl
Manufacturer:AvKARE
Route:ORAL
Strength:100 mg in 1 1
Approved: 2022/10/28
NDC:42291-125

Singapore Approved Products

SYMMETREL 100 CAPSULE 100 mg
Manufacturer:Catalent Germany Eberbach GmbH, Lek Pharmaceuticals d.d (Pri & sec packaging)
Form:CAPSULE
Strength:100 mg
Online:Yes
Approved: 1988/05/23
Approval:SIN01481P

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