MedPath

Amantadine

Generic Name
Amantadine
Brand Names
Gocovri, Osmolex
Drug Type
Small Molecule
Chemical Formula
C10H17N
CAS Number
768-94-5
Unique Ingredient Identifier
BF4C9Z1J53

Overview

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

Background

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

Indication

For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.

Associated Conditions

  • Dyskinesia
  • Extrapyramidal disorder caused by neuroleptic drugs without Tardive dyskinesia
  • Influenza A Virus Infection
  • Parkinson's Disease (PD)
  • Parkinson's Disease With Wearing-off Motor Fluctuations
  • Parkinsonism

Clinical Trials

Phase 3
Terminated
Posted: 2021/07/07
Sponsor:
Noblewell
Phase 3
Posted: 2021/05/20
Sponsor:
Copenhagen Universit...

FDA Approved Products

GOCOVRI
Manufacturer:Adamas Pharma, LLC
Route:ORAL
Strength:68.5 mg in 1 1
Approved: 2024/02/08
NDC:70482-085
AMANTADINE HYDROCHLORIDE
Manufacturer:STAT RX USA LLC
Route:ORAL
Strength:100 mg in 1 1
Approved: 2010/09/16
NDC:16590-008
Amantadine HCL
Manufacturer:Direct_Rx
Route:ORAL
Strength:100 mg in 1 1
Approved: 2023/03/03
NDC:72189-412
Amantadine Hydrochloride
Manufacturer:Marlex Pharmaceuticals Inc
Route:ORAL
Strength:100 mg in 1 1
Approved: 2023/10/19
NDC:10135-693
AMANTADINE HYDROCHLORIDE
Manufacturer:Unit Dose Services
Route:ORAL
Strength:50 mg in 5 mL
Approved: 2012/08/29
NDC:50436-0646

Singapore Approved Products

No Singapore products found for this drug

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