Levonorgestrel

Generic Name: Levonorgestrel

Brand Names: Afirmelle 28 Day, Aftera, Alesse, Altavera 28 Day, Amethia 91 Day, Amethyst, Ashlyna 91 Day, Aubra 28 Day, Aviane 28, Ayuna 28 Day Pack, Balcoltra 28 Day, Bionafem, Camrese 91 Day, Camreselo 91 Day, Chateal 28 Day, Climara Pro, Curae, Daysee 91 Day, Delyla 28 Day, Dolishale 28 Day, Econtra, Enpresse 28 Day, Fallback Solo, Falmina 28 Day, Fayosim 91 Day, Her Style, Iclevia 91 Day, Indayo, Introvale 91 Day, Jaimiess 91 Day, Jolessa 91 Day, Joyeaux 28 Day, Kurvelo, Kyleena, Larissia 28 Day Pack, Levonest 28 Day, Levora 0.15/30 28 Day, Liletta, Lillow 28 Day, Lo Simpesse, LoJaimiess, Loseasonique, Lutera 28 Day, Marlissa 28 Day, Min-ovral, Mirena, Morning After, My Choice, My Way, Myzilra 28 Day, New Day, Next Choice, Next Choice One Dose, Opcicon One-step, Option 2, Orsythia 28 Day, Plan B, Plan B One-step, Portia 28 Day, Preventeza, Quartette 91 Day Pack, React, Rivelsa 91 Day, Seasonale, Seasonique, Setlakin 91 Day, Simpesse, Skyla, Sronyx 28 Day, Take Action, Triquilar, Trivora 28 Day, Twirla 3 Count Weekly Patch, Tyblume 28 Day, Vienva 28 Day

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₈O_₂

CAS Number: 797-63-7

Unique Ingredient Identifier: 5W7SIA7YZW

Background: Levonorgestrel (LNG) is a synthetic progestogen similar to Progesterone used in contraception and hormone therapy. Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices are known as Jaydess, Kyleena, and Mirena....

Indication: Emergency contraception
...

Associated Conditions: Endometrial Hyperplasia, Endometriosis, Heavy Menstrual Bleeding, Hypermenorrhea, Postmenopausal Osteoporosis, Pregnancy, Moderate Menopausal Vasomotor Symptoms, Severe Vasomotor Symptoms Associated With Menopause

Associated Therapies: Emergency Contraception

Clinical Trials

Levonorgestrel-piroxicam Versus Ulipristal Acetate for Emergency Contraception

Phase 3

Not yet recruiting

Conditions: Contraception

Interventions: Drug: Levonorgestrel
Drug: Ulipristal Acetate
Drug: Piroxicam
Drug: Placebo - LNG
Drug: Placebo - UPA
Drug: Placebo - Piroxicam

First Posted Date: 2024-12-11

Last Posted Date: 2024-12-11

Lead Sponsor: The University of Hong Kong

Target Recruit Count: 980

Registration Number: NCT06727734

Assessing the Efficacy and Acceptability of Two Missed Period Pills Regimens

Phase 2

Not yet recruiting

Conditions: Pregnancy Related
Pregnancy Early

Interventions: Drug: Levonorgestrel
Drug: Mifepristone

First Posted Date: 2024-07-09

Last Posted Date: 2024-07-18

Lead Sponsor: Gynuity Health Projects

Target Recruit Count: 286

Registration Number: NCT06492889

Weight-loss Drug for Fertility-Sparing Treatment of Atypical Hyperplasia and Grade 1 Cancer of the Endometrium

Phase 2

Not yet recruiting

Conditions: Endometrial Cancer
Atypical Hyperplasia

Interventions: Drug: Mirena
Drug: Mounjaro

First Posted Date: 2023-10-10

Last Posted Date: 2024-03-19

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 108

Registration Number: NCT06073184

A Pilot Study on Fertility Conservative Treatment of Atypical Endometrial Hyperplasia in Singapore

Phase 2

Conditions: Endometrial Hyperplasia
Fertility Issues
Disease Regression
Treatment Side Effects

Interventions: Drug: Mirena
Drug: Megace

First Posted Date: 2022-08-08

Last Posted Date: 2022-08-08

Lead Sponsor: KK Women's and Children's Hospital

Target Recruit Count: 60

Registration Number: NCT05492487

Locations: 🇸🇬
Singapore General Hospital, Singapore, Singapore
🇸🇬
National University Hospital, Singapore, Singapore
🇸🇬
KK Women's and Children's Hospital, Singapore, Singapore

Kuwa Free! - Live Free!

Not Applicable

Recruiting

Conditions: HIV Infections
Contraception
Drug-drug Interaction

Interventions: Drug: Cabotegravir/ Rilpivirine
Drug: NNRTI, PI, or INSTI-containing 1st or 2nd line ART regimens
Drug: Intramuscular depo-medroxyprogesterone acetate (IM DMPA)
Drug: Etonogestrel (ETG) implant
Drug: Levonorgestrel

First Posted Date: 2021-09-16

Last Posted Date: 2024-04-10

Lead Sponsor: University of Alabama at Birmingham

Target Recruit Count: 700

Registration Number: NCT05044962

Locations: 🇰🇪
Academic Model Providing Access to Healthcare (AMPATH) Moi Teaching And Referral Hospital (MTRH), Eldoret, Kenya

Assessing Use Of Mifepristone After Progestin Priming For Use As "Missed Period Pills"

Phase 2

Conditions: Missed Menstrual Period

Interventions: Drug: Levonorgestrel
Drug: Mifepristone

First Posted Date: 2020-12-21

Last Posted Date: 2021-08-12

Lead Sponsor: Gynuity Health Projects

Target Recruit Count: 139

Registration Number: NCT04676776

Locations: 🇲🇽
Cuidado Integral de la Mujer, Gineclinic, S.C, Mexico City, Mexico

Study Comparing Emergency Contraception Effectiveness in Women Who Weight ≥ 80 kg

Phase 4

Conditions: Contraception

Interventions: Drug: Ulipristal Acetate
Drug: Levonorgestrel

First Posted Date: 2018-05-25

Last Posted Date: 2019-10-08

Lead Sponsor: Health Decisions

Target Recruit Count: 1200

Registration Number: NCT03537768

Locations: 🇺🇸
Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States
🇺🇸
University of Pittsburgh/Magee Women's Hospital, Pittsburgh, Pennsylvania, United States
🇺🇸
Oregon Health Science University, Portland, Oregon, United States

and more 15 locations

KYleena Satisfaction Study / Observational Study on User Satisfaction With the Levonorgestrel Intrauterine Delivery System Kyleena (LNG-IUS 12) in New Contraceptive Users and After Switching From Another Contraceptive Method

Completed

Conditions: Contraception

Interventions: Drug: Kyleena

First Posted Date: 2017-06-09

Last Posted Date: 2021-03-29

Lead Sponsor: Bayer

Target Recruit Count: 1134

Registration Number: NCT03182140

Locations: 🇺🇸
Visions Clinical Research, Wellington, Florida, United States
🇺🇸
Saginaw Valley Medical Research Group, LLC, Saginaw, Michigan, United States
🇸🇪
Many locations, Multiple Locations, Sweden

and more 10 locations