Misoprostol

Generic Name
Misoprostol
Brand Names
Arthrotec, Cytotec, Mifegymiso
Drug Type
Small Molecule
Chemical Formula
C22H38O5
CAS Number
59122-46-2
Unique Ingredient Identifier
0E43V0BB57
Background

Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and f...

Indication

Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the manage...

Associated Conditions
Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
Associated Therapies
Induction of cervix ripening therapy, Medically induced abortion
Clinical Trials
Related News

Vaginal Misoprostol to Improve the Neonatal Respiratory Outcome

Not Applicable
Conditions
Neonatal Respiratory Distress
Interventions
Drug: Misoprostol
First Posted Date
2017-08-04
Last Posted Date
2018-01-08
Lead Sponsor
Assiut University
Target Recruit Count
292
Registration Number
NCT03239327
Locations
🇪🇬

women health center,Assiut university, Assiut, Egypt

Comparing Two Medical Treatments for Early Pregnancy Failure.

Phase 4
Terminated
Conditions
Early Pregnancy Failure
Interventions
Drug: Mifepristone
Drug: Misoprostol
First Posted Date
2017-07-11
Last Posted Date
2020-05-01
Lead Sponsor
Radboud University Medical Center
Target Recruit Count
342
Registration Number
NCT03212352
Locations
🇳🇱

Amphia Hospital, Breda, Netherlands

🇳🇱

Rijnstate, Arnhem, Gelderland, Netherlands

🇳🇱

Radboud University Medical Centre, Nijmegen, Gelderland, Netherlands

and more 10 locations

Preoperative vs. Postoperative Rectal Misoprostol in Cesarean Section

Phase 2
Completed
Conditions
Neonatal Outcome
Interventions
Drug: Misoprostol
Other: Placebo
First Posted Date
2017-05-11
Last Posted Date
2018-03-22
Lead Sponsor
Ain Shams University
Target Recruit Count
300
Registration Number
NCT03148717
Locations
🇪🇬

Ain Shams University, Cairo, Egypt

Intrauterine Misoprostol Versus Intravenous Oxytocin Infusion During Cesarean Delivery

Phase 3
Completed
Conditions
Post Partum Hemorrhage
Interventions
Drug: Misoprostol
Drug: Oxytocin
First Posted Date
2017-05-11
Last Posted Date
2021-04-23
Lead Sponsor
Assiut University
Target Recruit Count
240
Registration Number
NCT03148574
Locations
🇪🇬

Assiut Faculty of Medicine, Assiut, Egypt

Management of Women With an Incomplete Miscarriage

Not Applicable
Completed
Conditions
Miscarriage
Interventions
Drug: Misoprostol
First Posted Date
2017-05-11
Last Posted Date
2020-07-21
Lead Sponsor
Assiut University
Target Recruit Count
84
Registration Number
NCT03148561
Locations
🇪🇬

Women Health Hospital - Assiut university, Assiut, Egypt

Preoperative vs. Postoperative Misoprostol in Elective Cesarean Section

Phase 2
Completed
Conditions
Cesarean Section
Interventions
Drug: Misoprostol
Other: Placebo
First Posted Date
2017-05-08
Last Posted Date
2018-03-22
Lead Sponsor
Ain Shams University
Target Recruit Count
240
Registration Number
NCT03144401
Locations
🇪🇬

Ain Shams University, Cairo, Egypt

Misoprostol With And Without Transcervical Balloon Catheter In Second Trimester Termination Of Pregnancy

First Posted Date
2017-04-10
Last Posted Date
2017-05-09
Lead Sponsor
Ain Shams Maternity Hospital
Target Recruit Count
108
Registration Number
NCT03106389
Locations
🇪🇬

Ain Shams University Maternity Hospital, Cairo Governorate, Cairo, Egypt

Vaginal Misoprostol Before IUD Insertion in Women With Cesarean Scar

First Posted Date
2017-03-16
Last Posted Date
2017-11-06
Lead Sponsor
Cairo University
Target Recruit Count
120
Registration Number
NCT03081442
Locations
🇪🇬

Kasr Alainy medical school, Cairo, Egypt

Mifepristone and Misoprostol Compared With Misoprostol Alone for Second Trimester Abortion

First Posted Date
2017-02-06
Last Posted Date
2017-02-06
Lead Sponsor
Rambam Health Care Campus
Target Recruit Count
200
Registration Number
NCT03044093
Locations
🇮🇱

Rambam Medical Campus, Haifa, Israel

Early Amniotomy Versus Delayed Amniotomy Following Foley Catheter Ripening in Nulliparous Labor Induction

First Posted Date
2017-02-01
Last Posted Date
2023-04-03
Lead Sponsor
Northwestern University
Target Recruit Count
69
Registration Number
NCT03039036
Locations
🇺🇸

Prentice Women's Hospital, Chicago, Illinois, United States

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