Misoprostol

Generic Name
Misoprostol
Brand Names
Arthrotec, Cytotec, Mifegymiso
Drug Type
Small Molecule
Chemical Formula
C22H38O5
CAS Number
59122-46-2
Unique Ingredient Identifier
0E43V0BB57
Background

Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and frequency of contractions and decrease cervical tone.

Misoprostol was granted FDA approval on 27 December 1988.

Indication

Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the management of miscarriages, prevention of post partum hemorrhage, and is also used alone or in combination with mifepristone in other countries for first trimester abortions.

Associated Conditions
Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
Associated Therapies
Induction of cervix ripening therapy, Medically induced abortion
Clinical Trials
Related News

Sublingual Misoprostol & Isoflurane During Caesarean Section

Phase 2
Completed
Conditions
Pregnancy
Cesarean Delivery
Interventions
Drug: Placebo
Drug: Misoprostol
First Posted Date
2011-11-08
Last Posted Date
2011-11-08
Lead Sponsor
Mansoura University
Target Recruit Count
366
Registration Number
NCT01466530
Locations
🇪🇬

College of Medicine, Mansoura University, Mansoura, DK, Egypt

Misoprostol for Secondary Prevention of Postpartum Hemorrhage at the Community Level in India

Not Applicable
Completed
Conditions
Postpartum Hemorrhage
Interventions
Drug: Misoprostol
First Posted Date
2011-10-31
Last Posted Date
2014-06-16
Lead Sponsor
Gynuity Health Projects
Target Recruit Count
3032
Registration Number
NCT01462422
Locations
🇮🇳

Deliveries at health sub-centers and homes, Bijapur, Karnataka, India

Effect of Preoperative Buccal Misoprostol on Blood Loss in Second-trimester Dilation and Evacuation Abortion

Phase 3
Terminated
Conditions
Abortion
Blood Loss
Interventions
Other: Folic acid
Drug: Misoprostol
First Posted Date
2011-09-19
Last Posted Date
2017-05-30
Lead Sponsor
Boston University
Target Recruit Count
3
Registration Number
NCT01436266
Locations
🇺🇸

Boston Medical Center, Boston, Massachusetts, United States

Intra Uterine Device Insertion in Nulliparous Women

Not Applicable
Terminated
Conditions
Contraception
Interventions
Drug: Misoprostol
Other: Placebo
First Posted Date
2011-08-23
Last Posted Date
2017-02-02
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
3
Registration Number
NCT01422226
Locations
🇺🇸

University of Colorado Hopspital, The Children's Hospital, Aurora, Colorado, United States

Control of Blood Loss During Caesarean Section

First Posted Date
2011-08-08
Last Posted Date
2014-10-07
Lead Sponsor
Cairo University
Target Recruit Count
600
Registration Number
NCT01412073
Locations
🇪🇬

faculty of medicine , Cairo University, Cairo, Egypt

Prevention of Postpartum Haemorrhage With Sublingual Misoprostol or Oxytocin

Phase 3
Completed
Conditions
Postpartum Hemorrhage
Interventions
Drug: Misoprostol
Drug: Oxytocin
First Posted Date
2011-06-14
Last Posted Date
2011-06-14
Lead Sponsor
Jawaharlal Nehru Medical College
Target Recruit Count
652
Registration Number
NCT01373359
Locations
🇮🇳

Jawaharlal Nehru Medical College, Belgaum, Karnataka, India

Misoprostol Prior to Intrauterine Device (IUD) Insertion in Nulliparous Women

Not Applicable
Completed
Conditions
Pain
Interventions
Drug: Placebo
Drug: Misoprostol
First Posted Date
2011-03-02
Last Posted Date
2016-03-28
Lead Sponsor
University of New Mexico
Target Recruit Count
85
Registration Number
NCT01307111

Pharmacokinetics of Misoprostol With Titrated Oral Administration

Phase 1
Completed
Conditions
Hypotonic; Labor
Interventions
Drug: Misoprostol
First Posted Date
2011-01-06
Last Posted Date
2016-01-28
Lead Sponsor
China Medical University Hospital
Target Recruit Count
10
Registration Number
NCT01271257
Locations
🇨🇳

China Medical University Beigang Hospital, Yunlin Xian, Taiwan

Evaluation the Blood Loss in Pregnancies With Misoprostol-induced Labour

Phase 4
Completed
Conditions
Pregnancy
Induced Labor
Interventions
Drug: Misoprostol
First Posted Date
2010-11-01
Last Posted Date
2010-11-16
Lead Sponsor
Maternidade Escola Assis Chateaubriand
Target Recruit Count
161
Registration Number
NCT01231126
Locations
🇧🇷

Maternidade-Escola Assis Chateaubriand, Fortaleza, Ceará, Brazil

Preoperative Misoprostol in Reducing Blood Loss in Total Abdominal Hysterectomy (TAH)

Not Applicable
Completed
Conditions
Hysterectomy
Interventions
Drug: Misoprostol
Drug: Vitamin B 6
First Posted Date
2010-09-10
Last Posted Date
2010-09-10
Lead Sponsor
The University of Hong Kong
Target Recruit Count
77
Registration Number
NCT01199159
Locations
🇭🇰

University of Hong Kong, Hong Kong, Hong Kong

© Copyright 2024. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy