Misoprostol

Generic Name
Misoprostol
Brand Names
Arthrotec, Cytotec, Mifegymiso
Drug Type
Small Molecule
Chemical Formula
C22H38O5
CAS Number
59122-46-2
Unique Ingredient Identifier
0E43V0BB57
Background

Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and f...

Indication

Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the manage...

Associated Conditions
Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
Associated Therapies
Induction of cervix ripening therapy, Medically induced abortion
Clinical Trials
Related News

Misoprostol For Nulliparous Women Before Hysteroscopy

First Posted Date
2010-07-05
Last Posted Date
2010-07-08
Lead Sponsor
Wenzhou Medical University
Target Recruit Count
120
Registration Number
NCT01156948
Locations
🇨🇳

the 1st Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China

A Prospective Randomized Comparison Trial on the Use of Mifepristone With Sublingual or Buccal Misoprostol for Medical Abortions of Less Than 9 Weeks Gestation

Phase 4
Completed
Conditions
Abortion, Legal
Interventions
Drug: Misoprostol
First Posted Date
2010-07-05
Last Posted Date
2011-08-05
Lead Sponsor
The University of Hong Kong
Target Recruit Count
90
Registration Number
NCT01156688
Locations
🇭🇰

Family Planning Association, Hong Kong, Hong Kong

Misoprostol Prior to Intrauterine Device (IUD) Insertion in Nulliparous Women

Not Applicable
Completed
Conditions
Contraception
Interventions
Drug: Placebo
Drug: Misoprostol
First Posted Date
2010-06-22
Last Posted Date
2018-01-12
Lead Sponsor
Emory University
Target Recruit Count
78
Registration Number
NCT01147497
Locations
🇺🇸

The Emory Clinic, Atlanta, Georgia, United States

Foley Catheter Versus Vaginal Misoprostol for Cervical Ripening and Induction of Labor

First Posted Date
2010-06-10
Last Posted Date
2010-06-10
Lead Sponsor
Municipal Hospital Vila Nova Cachoeirinha
Target Recruit Count
180
Registration Number
NCT01140971
Locations
🇧🇷

MHVNCachoeirinha, São Paulo, Brazil

Cervical Ripening for Induction of Labor: Misoprostol Versus Oxytocin in Conjunction With Foley Balloon

Not Applicable
Completed
Conditions
Induction of Labor
Interventions
Drug: Misoprostol
Drug: Oxytocin
First Posted Date
2010-06-09
Last Posted Date
2018-08-24
Lead Sponsor
Aultman Health Foundation
Target Recruit Count
50
Registration Number
NCT01139801
Locations
🇺🇸

Aultman Health Foundation, Canton, Ohio, United States

Non Surgical Management for Uterine Residua After Pregnancy Termination, Abortion or Delivery

Phase 2
Terminated
Conditions
Intra-uterine Residua
Interventions
Drug: misoprostol
First Posted Date
2010-06-02
Last Posted Date
2015-06-23
Lead Sponsor
HaEmek Medical Center, Israel
Target Recruit Count
23
Registration Number
NCT01134926
Locations
🇮🇱

HaEmek medical center, Afula, Israel

Intrarectal Misoprostol in Postpartum Haemorrhage

Phase 3
Completed
Conditions
Postpartum Haemorrhage
Interventions
Drug: Placebo
Drug: Misoprostol
First Posted Date
2010-05-04
Last Posted Date
2011-05-20
Lead Sponsor
University Hospital, Caen
Target Recruit Count
116
Registration Number
NCT01116050

Combined Use of Oxytocin and Misoprostol in the Prevention of Post Partum Haemorrhage

Phase 4
Terminated
Conditions
Hemorrhage; Complicating Delivery
Interventions
Drug: Misoprostol
First Posted Date
2010-04-29
Last Posted Date
2015-04-08
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
1721
Registration Number
NCT01113229
Locations
🇫🇷

Chi Poissy St Germain, Poissy, France

Fever After Misoprostol Administration for the Treatment of Primary Postpartum Hemorrhage

Not Applicable
Completed
Conditions
Postpartum Hemorrhage
Interventions
Drug: Misoprostol
First Posted Date
2010-03-04
Last Posted Date
2010-11-11
Lead Sponsor
Gynuity Health Projects
Target Recruit Count
50
Registration Number
NCT01080846
Locations
🇪🇨

Hospital Gineco Obstetrico Isidro Ayora, Quito, Pichincha, Ecuador

Efficacy and Safety of Titrated Oral Misoprostol Solution for Labor Induction at Term

Not Applicable
Completed
Conditions
Labor Induction at Term
First Posted Date
2010-02-18
Last Posted Date
2013-12-10
Lead Sponsor
University of Manitoba
Target Recruit Count
250
Registration Number
NCT01070472
Locations
🇨🇦

St. Boniface General Hospital, Winnipeg, Manitoba, Canada

© Copyright 2024. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy