Misoprostol

Generic Name
Misoprostol
Brand Names
Arthrotec, Cytotec, Mifegymiso
Drug Type
Small Molecule
Chemical Formula
C22H38O5
CAS Number
59122-46-2
Unique Ingredient Identifier
0E43V0BB57
Background

Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and f...

Indication

Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the manage...

Associated Conditions
Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
Associated Therapies
Induction of cervix ripening therapy, Medically induced abortion
Clinical Trials
Related News

Labour Induction With Misoprostol, Dinoprostone and Bard Catheter

First Posted Date
2008-01-28
Last Posted Date
2008-01-28
Lead Sponsor
Karolinska University Hospital
Target Recruit Count
592
Registration Number
NCT00602095

PReventive Efficacy and Safety of rEbamipide on Nsaid Induced Mucosal Toxicity

First Posted Date
2007-12-19
Last Posted Date
2011-11-16
Lead Sponsor
Korea Otsuka Pharmaceutical Co., Ltd.
Target Recruit Count
396
Registration Number
NCT00576706

Hysteroscopy After Pretreatment With Misoprostol and Estradiol Trial

Phase 3
Completed
Conditions
Cervical Ripening
Interventions
Drug: Placebo
Drug: Misoprostol
First Posted Date
2007-12-13
Last Posted Date
2009-05-25
Lead Sponsor
Ullevaal University Hospital
Target Recruit Count
100
Registration Number
NCT00572819
Locations
🇳🇴

Gynaecological Department, Ullevål University Hospital, Oslo, Norway

Titrated Oral Compared With Vaginal Misoprostol for Labor Induction at Term

Phase 3
Completed
Conditions
Labor Induction
Interventions
Drug: misoprostol
First Posted Date
2007-09-14
Last Posted Date
2007-09-14
Lead Sponsor
China Medical University Hospital
Target Recruit Count
220
Registration Number
NCT00529295
Locations
🇨🇳

China Medical University Beigang Hospital, Yun Lin, Taiwan

Outpatient Cervical Ripening With Orally Administered Misoprostol in Diabetics

Not Applicable
Terminated
Conditions
Diabetes, Gestational
Interventions
Dietary Supplement: Placebo
Drug: Misoprostol
First Posted Date
2007-08-10
Last Posted Date
2023-11-07
Lead Sponsor
MemorialCare Health System
Target Recruit Count
5
Registration Number
NCT00514618
Locations
🇺🇸

Long Beach Memorial Medical Center, Long Beach, California, United States

Sublingual Misoprostol Versus Standard Surgical Care for the Treatment of Incomplete Abortion

Not Applicable
Completed
Conditions
Incomplete Abortion
Interventions
Procedure: surgery
Drug: misoprostol
First Posted Date
2007-04-27
Last Posted Date
2012-03-30
Lead Sponsor
Gynuity Health Projects
Target Recruit Count
1000
Registration Number
NCT00466999
Locations
🇳🇪

Maternite Issaka Gazobi, Niamey, Niger

🇪🇬

Shatby Maternity Hospital/Alexandria University, Shatby, Alexandria, Egypt

🇸🇳

Centre de Sante Le Roi Baudouin, Guediawaye, Senegal

and more 3 locations

Comparing the Effect of Vaginal Misoprostol With Dinoprostone in Term Pregnancies

First Posted Date
2007-02-08
Last Posted Date
2007-06-01
Lead Sponsor
Hormozgan University of Medical Sciences
Registration Number
NCT00432588
Locations
🇮🇷

Shariaty Maternity Hospital, Tehran, Iran, Islamic Republic of

Misoprostol for Non-Viable Pregnancies

First Posted Date
2007-01-24
Last Posted Date
2008-02-08
Lead Sponsor
Madigan Army Medical Center
Target Recruit Count
30
Registration Number
NCT00426491
Locations
🇺🇸

Madigan Army Medical Center, Tacoma, Washington, United States

Comparison of Two Regimens of Misoprostol for Second Trimester Medical Termination of Pregnancy

Phase 4
Completed
Conditions
Induced Abortion
Interventions
Drug: Misoprostol
First Posted Date
2006-11-20
Last Posted Date
2010-03-12
Lead Sponsor
Nilratan Sircar Medical College
Target Recruit Count
185
Registration Number
NCT00401440
Locations
🇮🇳

Department of Gynae & Obstetrics, Nilratan Sircar Medical College , Kolkata, Kolkata, West Bengal, India

A Randomized, Control Trial for Preinduction Cervical Ripening

Phase 2
Completed
Conditions
Labor, Induced
First Posted Date
2006-10-29
Last Posted Date
2008-01-16
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
540
Registration Number
NCT00393731
Locations
🇺🇸

Lyndon B. Johnson Hospital, Houston, Texas, United States

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