Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and f...
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the manage...
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
Bleeding Pattern and User Satisfaction During Second Consecutive MIRENA® in Contraception and Treatment of Menorrhagia
- Conditions
- Interventions
- First Posted Date
- 2006-10-27
- Last Posted Date
- 2014-11-02
- Lead Sponsor
- Bayer
- Target Recruit Count
- 204
- Registration Number
- NCT00393198
Ripening Interventions: Prostaglandins vs EASI Catheter
- First Posted Date
- 2006-10-04
- Last Posted Date
- 2017-03-13
- Lead Sponsor
- Loyola University
- Target Recruit Count
- 80
- Registration Number
- NCT00383942
- Locations
- 🇺🇸
Loyola University Medical Center, Maywood, Illinois, United States
Comparison of Misoprostol and PGE2 Gel for Induction of Labour in Women With Premature Rupture of Membranes at Term
- Conditions
- Interventions
- First Posted Date
- 2006-07-25
- Last Posted Date
- 2010-03-25
- Lead Sponsor
- Nilratan Sircar Medical College
- Target Recruit Count
- 212
- Registration Number
- NCT00355966
- Locations
- 🇮🇳
NRS Medicl College,138 AJC Bose Road, Kolkata, West Bengal, India
Comparison of Misoprostol and Prostaglandin E2 (PGE2) Gel for Induction of Labour in Premature Rupture of Membranes at Term
- Conditions
- Interventions
- First Posted Date
- 2006-07-21
- Last Posted Date
- 2015-07-22
- Lead Sponsor
- Nilratan Sircar Medical College
- Target Recruit Count
- 932
- Registration Number
- NCT00355303
- Locations
- 🇮🇳
Nilratan Sircar Medical College, 138,AJC Bose Road,, Kolkata, West Bengal, India
Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester
- Conditions
- Interventions
- First Posted Date
- 2006-05-11
- Last Posted Date
- 2012-03-05
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 30
- Registration Number
- NCT00324519
- Locations
- 🇺🇸
Shands Hospital at the University of Florida, Gainesville, Florida, United States
Randomized Trial Comparing Misoprostol and Foley Bulb for Labor Induction in the Preterm Gestation
- Conditions
- First Posted Date
- 2006-05-11
- Last Posted Date
- 2012-03-02
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 130
- Registration Number
- NCT00325026
- Locations
- 🇺🇸
Shands Hospital at the University of Florida, Gainesville, Florida, United States
A Randomized Study of Cervical Priming With Misoprostol Prior to Elective First Trimester Pregnancy Termination
- Conditions
- First Posted Date
- 2006-04-05
- Last Posted Date
- 2007-04-11
- Lead Sponsor
- Kaiser Permanente
- Target Recruit Count
- 200
- Registration Number
- NCT00310921
- Locations
- 🇺🇸
Kaiser Permanente, Department of OB/GYN, San Francisco, California, United States
Trial Of Misoprostol And Dinoprostone Vaginal Pessaries for Cervical Priming (TROMAD Study)
- Conditions
- First Posted Date
- 2006-03-07
- Last Posted Date
- 2006-03-07
- Lead Sponsor
- KK Women's and Children's Hospital
- Target Recruit Count
- 171
- Registration Number
- NCT00299754
- Locations
- 🇸🇬
National University Hospital, Singapore, Singapore
Treatment of Late Abortion: Evacuatio Uteri or Conservative Treatment
- Conditions
- First Posted Date
- 2005-11-21
- Last Posted Date
- 2006-06-01
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 200
- Registration Number
- NCT00256009
Termination of Pregnancy With Mifepristone and Misoprostol Versus Sulprostone
- Conditions
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2007-10-30
- Lead Sponsor
- Atrium Medical Center
- Registration Number
- NCT00206193
- Locations
- 🇳🇱
Atrium Medisch Centrum, Heerlen, Limburg, Netherlands
Drug Development Updates
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