Misoprostol

Generic Name
Misoprostol
Brand Names
Arthrotec, Cytotec, Mifegymiso
Drug Type
Small Molecule
Chemical Formula
C22H38O5
CAS Number
59122-46-2
Unique Ingredient Identifier
0E43V0BB57
Background

Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and f...

Indication

Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the manage...

Associated Conditions
Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
Associated Therapies
Induction of cervix ripening therapy, Medically induced abortion
Clinical Trials
Related News

Oral Misoprostol Before Endometrial Biopsy

Phase 3
Completed
Conditions
Endometrial Biopsy
Interventions
Drug: misoprostol
Drug: vitamin B6
First Posted Date
2005-09-20
Last Posted Date
2007-09-21
Lead Sponsor
Memorial University of Newfoundland
Target Recruit Count
72
Registration Number
NCT00200226
Locations
🇨🇦

Women's Health Centre, Eastern Health, St. John's, Newfoundland and Labrador, Canada

🇨🇦

Obstetrics and Gynecology Associates, Dartmouth, Nova Scotia, Canada

Oral Versus Vaginal Misoprostol for Induction of Labor

First Posted Date
2005-09-08
Last Posted Date
2005-09-08
Lead Sponsor
Bangkok Metropolitan Administration Medical College and Vajira Hospital
Target Recruit Count
180
Registration Number
NCT00148473
Locations
🇹🇭

BMA Medical College and Vajira Hospital, Bangkok, Thailand

A Randomized Trial of Two Regimens of Misoprostol for Second Trimester Termination for Intrauterine Fetal Death

Phase 3
Terminated
Conditions
Labor Induction
Interventions
Drug: Misoprostol
First Posted Date
2005-09-02
Last Posted Date
2013-07-19
Lead Sponsor
American University of Beirut Medical Center
Target Recruit Count
73
Registration Number
NCT00141895
Locations
🇱🇧

American University of Beirut Medical Center, Beirut, Lebanon

Comparing Methotrexate Followed by Misoprostol to Misoprostol Alone for Early Abortion

Phase 4
Completed
Conditions
Unwanted Pregnancies
First Posted Date
2005-08-11
Last Posted Date
2018-06-11
Lead Sponsor
Wiebe, Ellen, M.D.
Target Recruit Count
300
Registration Number
NCT00129506
Locations
🇨🇦

Wiebe Early Abortion Clinic, Vancouver, British Columbia, Canada

Misoprostol for Preventing Postpartum Hemorrhage

Not Applicable
Completed
Conditions
Postpartum Hemorrhage
Interventions
Drug: placebo
Drug: misoprostol
First Posted Date
2005-07-28
Last Posted Date
2008-05-28
Lead Sponsor
Gynuity Health Projects
Target Recruit Count
1200
Registration Number
NCT00124540
Locations
🇺🇬

Mulago Hospital, Kampala, Uganda

🇿🇦

Rob Ferreira Hospital, Nelspruit, South Africa

🇿🇦

Dora Nginza Hospital, Port Elizabeth, South Africa

and more 2 locations

Misoprostol for the Prevention of Postpartum Hemorrhage in Rural Pakistan

Not Applicable
Completed
Conditions
Postpartum Hemorrhage
Anemia
First Posted Date
2005-07-15
Last Posted Date
2009-03-19
Lead Sponsor
Gynuity Health Projects
Target Recruit Count
1600
Registration Number
NCT00120237
Locations
🇵🇰

Home delivery setting, Chitral, Chitral District, Pakistan

Optimisation of the Management of Placental Delivery in Second Trimester Pregnancy Interruption

First Posted Date
2005-07-14
Last Posted Date
2009-07-09
Lead Sponsor
The University of Western Australia
Target Recruit Count
251
Registration Number
NCT00120042
Locations
🇦🇺

King Edward Memorial Hospital, Perth, Western Australia, Australia

Misoprostol in the Treatment of Postpartum Hemorrhage

Not Applicable
Completed
Conditions
Postpartum Hemorrhage
Interventions
Drug: Misoprostol
First Posted Date
2005-06-30
Last Posted Date
2009-03-19
Lead Sponsor
Gynuity Health Projects
Target Recruit Count
61
Registration Number
NCT00116480
Locations
🇵🇰

The Aga Khan Health Services, Karachi, Pakistan

🇵🇰

Aga Khan University Hospital, Karachi, Pakistan

Misoprostol for the Treatment of Postpartum Hemorrhage

Not Applicable
Completed
Conditions
Postpartum Hemorrhage
Interventions
Drug: Oxytocin
Drug: Misoprostol
First Posted Date
2005-06-29
Last Posted Date
2009-03-19
Lead Sponsor
Gynuity Health Projects
Target Recruit Count
1786
Registration Number
NCT00116350
Locations
🇹🇷

Ministry of Health Ankara Etlik Maternity and Teaching-Research Hospital, Ankara, Turkey

🇪🇨

Hospital Gineco-Obstetrico Isidro Ayora, Quito, Ecuador

🇧🇫

Centre Hospitalier Universitaire Souro Sanou de Bobo Dioulasso, Bobo Diolasso, Burkina Faso

and more 3 locations

Oral Misoprostol Versus Intravenous Oxytocin in Preventing Blood Loss After Non-scheduled Cesarean Section

Phase 2
Completed
Conditions
Postpartum Hemorrhage
First Posted Date
2005-04-12
Last Posted Date
2019-04-04
Lead Sponsor
University Hospital, Basel, Switzerland
Target Recruit Count
56
Registration Number
NCT00107874
Locations
🇨🇭

Women's University Hospital, Basel, Basel, Switzerland

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