Overview
Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.
Indication
Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.
Associated Conditions
- Allergic Reaction
- Bronchial Asthma
- Common Cold
- Cough
- Depression
- Fever
- General Anesthesia Induced Hypotension
- Headache
- Joint Pain
- Myasthenia Gravis
- Narcolepsy
- Nasal Congestion
- Rhinorrhoea
- Sore Throat
- Dry cough
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
---|---|---|---|---|---|
2025/07/16 | Not Applicable | Completed | |||
2025/06/24 | Phase 1 | Completed | |||
2025/04/10 | Phase 4 | Not yet recruiting | mehmet özkılıç | ||
2025/02/25 | N/A | Not yet recruiting | |||
2025/01/22 | N/A | Active, not recruiting | |||
2024/12/19 | N/A | Active, not recruiting | Centre of Postgraduate Medical Education | ||
2024/11/08 | Phase 4 | Recruiting | Matias Vested | ||
2024/10/31 | Phase 4 | Completed | |||
2024/07/12 | Not Applicable | Recruiting | |||
2024/03/25 | Phase 2 | Recruiting | Kasr El Aini Hospital |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
---|---|---|---|---|---|
Civica, Inc. | 72572-150 | INTRAVENOUS | 50 mg in 1 mL | 8/17/2020 | |
Gland Pharma Limited | 68083-495 | INTRAVENOUS | 50 mg in 1 mL | 1/12/2022 | |
Nexus Pharmaceuticals, LLC | 14789-252 | INTRAVENOUS | 5 mg in 1 mL | 2/14/2024 | |
Dr. Reddy's Laboratories, Inc. | 43598-725 | INTRAVENOUS | 50 mg in 1 mL | 12/24/2018 | |
Civica, Inc. | 72572-151 | INTRAVENOUS | 50 mg in 1 mL | 12/30/2023 | |
Medical Purchasing Solutions, LLC | 71872-7276 | INTRAVENOUS | 50 mg in 1 mL | 5/3/2023 | |
Exela Pharma Sciences, LLC | 51754-4250 | INTRAVENOUS | 5 mg in 1 mL | 11/27/2020 | |
Par Pharmaceutical, Inc. | 42023-243 | INTRAVENOUS | 5 mg in 1 mL | 1/30/2024 | |
Hikma Pharmaceuticals USA Inc. | 0641-6238 | INTRAVENOUS | 50 mg in 1 mL | 9/24/2020 | |
Par Pharmaceutical, Inc. | 42023-233 | INTRAVENOUS | 500 mg in 10 mL | 8/14/2021 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
---|---|---|---|
No EMA approvals found for this drug. |
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
---|---|---|---|---|---|
EPHEDRINE AGUETTANT SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 30 MG/ 10 ML | SIN16846P | INJECTION, SOLUTION | 30 mg/ 10 ml | 8/25/2023 | |
SUNSEDYL FORTE COUGH LINCTUS | SIN07750P | ELIXIR | 7.2 mg/5 ml | 6/21/1994 | |
EPHEDRINE AGUETTANT SOLUTION FOR INJECTION 30MG/ML | SIN15912P | INJECTION, SOLUTION | 30mg/ml | 3/17/2020 | |
DBL EPHEDRINE SULFATE INJECTION 30 mg/ml | SIN02734P | INJECTION | 30 mg/ml | 5/6/1989 | |
DHASEDYL SYRUP | SIN06928P | SYRUP | 6 mg/5 ml | 4/13/1992 | |
DIPRODIN ELIXIR | SIN07830P | ELIXIR | 6 mg/5 ml | 9/1/1994 | |
MARTINDALE PHARMA EPHEDRINE HYDROCHLORIDE SOLUTION FOR INJECTION 30MG/ML | SIN15678P | INJECTION, SOLUTION | 30 mg/ml | 5/3/2019 | |
EPHEDRINE NASAL DROPS BPC | SIN04850P | SOLUTION | 0.5% w/v | 6/28/1990 | |
PROMEDYL-B LINCTUS | SIN02838P | ELIXIR | 7.2 mg/5 ml | 5/22/1989 | |
SUNSEDYL COUGH LINCTUS | SIN03490P | ELIXIR | 7.2 mg/5 ml | 6/26/1989 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
---|---|---|---|---|---|
No NMPA approvals found for this drug. |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
---|---|---|---|---|---|
PROSEDYL COUGH SYRUP | N/A | N/A | N/A | 8/20/1985 | |
MOTRACK COUGH SYRUP | N/A | N/A | N/A | 9/14/2010 | |
NEW MARSEDYL-DM ELIXIR | N/A | N/A | N/A | 8/11/2015 | |
NICE PHENDYL-B LINCTUS | N/A | N/A | N/A | 7/15/1982 | |
MERSIDYL SYRUP | N/A | N/A | N/A | 2/25/1986 | |
COCLEAN SYRUP | N/A | N/A | N/A | 6/15/2001 | |
COFFTIER COUGH SYRUP | N/A | N/A | N/A | 2/15/2008 | |
MARSEDYL ELIXIR | N/A | N/A | N/A | 2/25/1984 | |
PFC COUGH SYRUP CM FORMULA | N/A | N/A | N/A | 7/9/2010 | |
PACTOREX SYRUP | N/A | N/A | N/A | 4/20/1979 |
TGA Drug Approvals
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
---|---|---|---|---|---|
THUNAS PILE SUP | thuna herbal remedies ltd. | 00457299 | Suppository - Rectal | 2.5 MG / SUP | 12/31/1945 |
EPHEDRINE SULFATE INJECTION USP | 00876534 | Solution - Intravenous
,
Subcutaneous
,
Intramuscular | 50 MG / ML | 12/31/1990 | |
BALMINIL NASAL OINTMENT | rougier pharma division of ratiopharm inc | 02135639 | Ointment - Nasal | 6 MG / G | 12/31/1995 |
SPINAL ANESTHESIA TRAY | baxter corporation | 01909509 | Liquid - Subcutaneous
,
Block/Infiltration | 5 % / KIT | 12/31/1992 |
GRIPPALIN | distributions multi-pro inc. | 02241160 | Tablet - Oral | 8 MG / TAB | 9/13/2000 |
VICKS COUGH SYRUP NEW IMPROVED | richardson-vicks, division of the procter & gamble company | 00589802 | Syrup - Oral | 8 MG / 15 ML | 12/31/1983 |
DYMETADRINE 25 - TAB | added dimensions | 02227142 | Tablet - Oral | 25 MG | 12/23/1996 |
EPHEDRINE SULFATE INJECTION USP, 50MG/ML | alveda pharmaceuticals inc | 02300540 | Liquid - Intramuscular
,
Subcutaneous
,
Intravenous | 50 MG / ML | N/A |
EPHEDRINE HCL 8 MG | nutrition zone products inc. | 02245602 | Tablet - Oral | 8 MG | 9/20/2002 |
SPINAL ANESTHESIA TRAY | baxter corporation | 01975471 | Liquid - Block/Infiltration | 5 % / KIT | 12/31/1992 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
---|---|---|---|---|---|
No CIMA AEMPS (Spain) approvals found for this drug. |
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
---|---|---|---|---|---|
No Philippines FDA approvals found for this drug. |
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
---|---|---|---|---|---|
No Saudi SFDA approvals found for this drug. |
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
---|---|---|---|---|---|
No Malaysia NPRA approvals found for this drug. |
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
---|---|---|---|---|---|
No UK EMC drug information found for this drug. |
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