MedPath

Ephedrine

Generic Name
Ephedrine
Brand Names
Akovaz, Bronkaid, Corphedra, Emerphed, Primatene, Rezipres
Drug Type
Small Molecule
Chemical Formula
C10H15NO
CAS Number
299-42-3
Unique Ingredient Identifier
GN83C131XS

Overview

Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.

Indication

Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.

Associated Conditions

  • Allergic Reaction
  • Bronchial Asthma
  • Common Cold
  • Cough
  • Depression
  • Fever
  • General Anesthesia Induced Hypotension
  • Headache
  • Joint Pain
  • Myasthenia Gravis
  • Narcolepsy
  • Nasal Congestion
  • Rhinorrhoea
  • Sore Throat
  • Dry cough

Clinical Trials

Title
Posted
Study ID
Phase
Status
Sponsor
2025/07/16
Not Applicable
Completed
2025/06/24
Phase 1
Completed
2025/04/10
Phase 4
Not yet recruiting
mehmet özkılıç
2025/02/25
N/A
Not yet recruiting
2025/01/22
N/A
Active, not recruiting
2024/12/19
N/A
Active, not recruiting
Centre of Postgraduate Medical Education
2024/11/08
Phase 4
Recruiting
Matias Vested
2024/10/31
Phase 4
Completed
2024/07/12
Not Applicable
Recruiting
2024/03/25
Phase 2
Recruiting
Kasr El Aini Hospital

FDA Drug Approvals

Approved Product
Manufacturer
NDC Code
Route
Strength
Effective Date
Civica, Inc.
72572-150
INTRAVENOUS
50 mg in 1 mL
8/17/2020
Gland Pharma Limited
68083-495
INTRAVENOUS
50 mg in 1 mL
1/12/2022
Nexus Pharmaceuticals, LLC
14789-252
INTRAVENOUS
5 mg in 1 mL
2/14/2024
Dr. Reddy's Laboratories, Inc.
43598-725
INTRAVENOUS
50 mg in 1 mL
12/24/2018
Civica, Inc.
72572-151
INTRAVENOUS
50 mg in 1 mL
12/30/2023
Medical Purchasing Solutions, LLC
71872-7276
INTRAVENOUS
50 mg in 1 mL
5/3/2023
Exela Pharma Sciences, LLC
51754-4250
INTRAVENOUS
5 mg in 1 mL
11/27/2020
Par Pharmaceutical, Inc.
42023-243
INTRAVENOUS
5 mg in 1 mL
1/30/2024
Hikma Pharmaceuticals USA Inc.
0641-6238
INTRAVENOUS
50 mg in 1 mL
9/24/2020
Par Pharmaceutical, Inc.
42023-233
INTRAVENOUS
500 mg in 10 mL
8/14/2021

EMA Drug Approvals

Approved Product
Authorization Holder
Status
Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

NMPA Drug Approvals

Approved Product
Company
Approval Number
Drug Type
Dosage Form
Approval Date
No NMPA approvals found for this drug.

Health Canada Drug Approvals

Approved Product
Company
DIN
Dosage Form
Strength
Market Date
THUNAS PILE SUP
thuna herbal remedies ltd.
00457299
Suppository - Rectal
2.5 MG / SUP
12/31/1945
EPHEDRINE SULFATE INJECTION USP
00876534
Solution - Intravenous ,  Subcutaneous ,  Intramuscular
50 MG / ML
12/31/1990
BALMINIL NASAL OINTMENT
rougier pharma division of ratiopharm inc
02135639
Ointment - Nasal
6 MG / G
12/31/1995
SPINAL ANESTHESIA TRAY
baxter corporation
01909509
Liquid - Subcutaneous ,  Block/Infiltration
5 % / KIT
12/31/1992
GRIPPALIN
distributions multi-pro inc.
02241160
Tablet - Oral
8 MG / TAB
9/13/2000
VICKS COUGH SYRUP NEW IMPROVED
richardson-vicks, division of the procter & gamble company
00589802
Syrup - Oral
8 MG / 15 ML
12/31/1983
DYMETADRINE 25 - TAB
added dimensions
02227142
Tablet - Oral
25 MG
12/23/1996
EPHEDRINE SULFATE INJECTION USP, 50MG/ML
alveda pharmaceuticals inc
02300540
Liquid - Intramuscular ,  Subcutaneous ,  Intravenous
50 MG / ML
N/A
EPHEDRINE HCL 8 MG
nutrition zone products inc.
02245602
Tablet - Oral
8 MG
9/20/2002
SPINAL ANESTHESIA TRAY
baxter corporation
01975471
Liquid - Block/Infiltration
5 % / KIT
12/31/1992

CIMA AEMPS Drug Approvals

Approved Product
Company
Registration Number
Pharmaceutical Form
Prescription Type
Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product
Company
License Number
Dosage Form
Strength
Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product
Company
License Number
Dosage Form
Strength
Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product
Company
Registration Number
Dosage Form
Strength
Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name
MA Holder
MA Number
Pharmaceutical Form
Active Ingredient
Authorization Date
No UK EMC drug information found for this drug.

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