Mebendazole

Generic Name: Mebendazole

Brand Names: Emverm, Vermox

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₃N_₃O_₃

CAS Number: 31431-39-7

Unique Ingredient Identifier: 81G6I5V05I

Background: A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]

Indication: For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.

Associated Conditions: Ancylostoma caninum infection, Ancylostoma duodenale infection, Ascaris lumbricoides infection, Capillariasis, Enterobius vermicularis infection, Filariasis, Giardiasis, Necatoriasis due to necator americanus, Strongyloides Stercoralis Infection, Taenia solium infection, Toxocariasis, Whipworm infection

Associated Therapies: -

Clinical Trials

Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections

Phase 3

Not yet recruiting

Conditions: Trichuris Trichiura; Infection
Hookworm Infection
Ascaris Lumbricoides Infection

Interventions: Drug: emodepside (BAY 44-4400)
Drug: matching placebo of emodepside
Drug: similar placebo to mebendazole
Drug: Mebendazole

First Posted Date: 2024-12-17

Last Posted Date: 2024-12-19

Lead Sponsor: Swiss Tropical & Public Health Institute

Target Recruit Count: 315

Registration Number: NCT06736691

Locations: 🇹🇿
Public Health Laboratory - Ivo de Carneri (PHL-IdC), Chake Chake, Tanzania

Efficacy and Safety of Oxantel Pamoate in Children Infected with Trichuris Trichiura

Phase 2

Not yet recruiting

Conditions: Trichuris Trichiura; Infection
Ascaris Lumbricoides Infection
Hookworm Infection

Interventions: Drug: Oxantel Pamoate
Drug: Mebendazole

First Posted Date: 2024-12-06

Last Posted Date: 2024-12-13

Lead Sponsor: Jennifer Keiser

Target Recruit Count: 165

Registration Number: NCT06720259

Locations: 🇹🇿
Public Health Laboratory Ivo de Carneri, Chake Chake, Tanzania

Possible Efficacy and Safety of Mebendazole in Patients With Ulcerative Colitis Treated With Mesalamine

Not Applicable

Not yet recruiting

Conditions: Ulcerative Colitis

Interventions: Drug: Mebendazole

First Posted Date: 2024-03-28

Last Posted Date: 2024-03-28

Lead Sponsor: Tanta University

Target Recruit Count: 46

Registration Number: NCT06335160

To Study the Effects of Addition of Mebendazole to Lenvatinib in Cirrhotics With Advanced Hepatocellular Carcinoma.

Not Applicable

Conditions: Hepatocellular Carcinoma
Liver Cirrhosis

Interventions: Drug: Lenvatinib
Other: Placebo
Drug: Mebendazole

First Posted Date: 2020-06-23

Last Posted Date: 2021-10-05

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 170

Registration Number: NCT04443049

Locations: 🇮🇳
Institute of Liver & Biliary Sciences, New Delhi, Delhi, India

Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm

Phase 2

Completed

Conditions: Hookworm Infections

Interventions: Drug: Mebendazole

First Posted Date: 2019-06-24

Last Posted Date: 2020-07-20

Lead Sponsor: Swiss Tropical & Public Health Institute

Target Recruit Count: 397

Registration Number: NCT03995680

Locations: 🇹🇿
Public Health Laboratory Ivo de Carneri, Chake Chake, Tanzania

Mebendazole as Adjuvant Treatment for Colon Cancer

Phase 3

Recruiting

Conditions: Colorectal Cancer

Interventions: Drug: Folfox with avastin
Drug: Mebendazole

First Posted Date: 2019-04-24

Last Posted Date: 2019-04-24

Lead Sponsor: Sherief Abd-Elsalam

Target Recruit Count: 40

Registration Number: NCT03925662

Locations: 🇪🇬
Sherief Abd-Elsalam, Cairo, Egypt

Triple Combinations Against Hookworm Infections in Lao

Phase 4

Completed

Conditions: Hookworm Infection

Interventions: Drug: Albendazole
Drug: Oxantel Pamoate
Drug: Pyrantel Pamoate
Drug: Mebendazole

First Posted Date: 2017-09-11

Last Posted Date: 2018-05-08

Lead Sponsor: Swiss Tropical & Public Health Institute

Target Recruit Count: 420

Registration Number: NCT03278431

Locations: 🇱🇦
Nambak District Hospital, Luang Prabang, Lao People's Democratic Republic

Mebendazole Study Against Hookworm Infections in Children and Adolescents in Ghana

Phase 4

Withdrawn

Conditions: Hookworm Infections

Interventions: Drug: Mebendazole

First Posted Date: 2017-08-25

Last Posted Date: 2017-11-17

Lead Sponsor: PATH

Registration Number: NCT03261596

Locations: 🇬🇭
Noguchi Memorial Institute for Medical Research - University of Ghana, Legon, Accra, Ghana

Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors

Phase 1

Completed

Conditions: Medulloblastoma
Astrocytoma, Grade III
Glioblastoma
Anaplastic Astrocytoma
Brain Stem Neoplasms, Malignant
Oligodendroblastoma
Anaplastic Oligodendroglioma
Malignant Glioma

Interventions: Drug: Mebendazole

First Posted Date: 2015-12-31

Last Posted Date: 2022-06-23

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 16

Registration Number: NCT02644291

Locations: 🇺🇸
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida, United States
🇺🇸
Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Study to Evaluate Efficacy and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population

Phase 4

Completed

Conditions: Helminthiasis
Amoebiasis

Interventions: Drug: Mebendazole
Drug: Quinfamide
Drug: Placebo

First Posted Date: 2015-03-11

Last Posted Date: 2015-04-14

Lead Sponsor: Janssen-Cilag Ltd.

Target Recruit Count: 100

Registration Number: NCT02385058

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