Mebendazole

Generic Name
Mebendazole
Brand Names
Emverm, Vermox
Drug Type
Small Molecule
Chemical Formula
C16H13N3O3
CAS Number
31431-39-7
Unique Ingredient Identifier
81G6I5V05I
Background

A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]

Indication

For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.

Associated Conditions
Ancylostoma caninum infection, Ancylostoma duodenale infection, Ascaris lumbricoides infection, Capillariasis, Enterobius vermicularis infection, Filariasis, Giardiasis, Necatoriasis due to necator americanus, Strongyloides Stercoralis Infection, Taenia solium infection, Toxocariasis, Whipworm infection
Associated Therapies
-
Clinical Trials
Related News

A Study to Assess the Efficacy and Safety of Mebendazole for the Treatment of Helminth Infections in Pediatric Participants

Phase 3
Completed
Conditions
Helminth Infections
Interventions
Drug: Placebo
Drug: Mebendazole
First Posted Date
2014-01-13
Last Posted Date
2016-11-04
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
295
Registration Number
NCT02034162

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

First Posted Date
2013-04-23
Last Posted Date
2024-07-05
Lead Sponsor
Julie Krystal
Target Recruit Count
36
Registration Number
NCT01837862
Locations
🇺🇸

Cohen Children's Medical Center of New York, New Hyde Park, New York, United States

Mebendazole in Newly Diagnosed High-Grade Glioma Patients Receiving Temozolomide

Phase 1
Completed
Conditions
Newly Diagnosed High-Grade Glioma
Interventions
Drug: Mebendazole
First Posted Date
2012-11-20
Last Posted Date
2021-05-07
Lead Sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Target Recruit Count
24
Registration Number
NCT01729260
Locations
🇺🇸

The Johs Hopkins Hospital, Baltimore, Maryland, United States

Monitoring the Efficacy of Anthelmintics for the Treatment of Soil Transmitted Helminths P2

First Posted Date
2011-06-23
Last Posted Date
2014-12-05
Lead Sponsor
University Ghent
Target Recruit Count
250
Registration Number
NCT01379326
Locations
🇹🇿

Ivo de Carneri, Pemba Island, Zanzibar, Tanzania

🇻🇳

National Institute for Malariology, Parasitology and Entomology, Hanoi, Vietnam

🇰🇭

Institut Pasteur in Cambodia, Clinical Pathology Unit, Phnom Penh, Cambodia

and more 6 locations

The Effect of a Deworming Intervention to Improve Early Childhood Growth and Development in Resource-poor Areas

First Posted Date
2011-03-15
Last Posted Date
2014-08-26
Lead Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Target Recruit Count
1760
Registration Number
NCT01314937
Locations
🇵🇪

Asociacion Civil Selva Amazonica, Iquitos, Loreto, Peru

A Safety Study of Mebendazole in Children 2 to 10 Years of Age

Phase 3
Completed
Conditions
Healthy Volunteers
Interventions
Drug: Mebendazole
First Posted Date
2010-08-02
Last Posted Date
2014-03-12
Lead Sponsor
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Target Recruit Count
397
Registration Number
NCT01173562

Safety and Efficacy of Drug Combinations Against Trichuris Trichiura

First Posted Date
2010-01-15
Last Posted Date
2010-01-15
Lead Sponsor
DBL -Institute for Health Research and Development
Target Recruit Count
750
Registration Number
NCT01050452
Locations
🇺🇬

Vector Control Division, Kampala, Uganda

Severe Anemia Treatment Trials, Pakistan

First Posted Date
2005-06-30
Last Posted Date
2012-04-09
Lead Sponsor
Johns Hopkins Bloomberg School of Public Health
Target Recruit Count
1009
Registration Number
NCT00116493
Locations
🇵🇰

Aga Khan University, Karachi, Sindh, Pakistan

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