D-glucose

Brand Names: As 3, Cpda-1 Blood Collection System, Dextrose and Electrolyte No. 75, Dianeal Low Calcium 1.5, Dianeal Pd-2/1.5, Ionosol-MB, Isolyte P, Leukotrap, Normosol-M, Plasma-lyte 148 In 5 % Dextrose, Prismasol

Background: Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through aerobic or anaerobic respiration and fermentation. It is primarily stored as starch in plants and glycogen in animals to be used in various metabolic processes in the cellular level. Its aldohexose stereoisomer, dextrose or D-glucose, is the most commonly occurring isomer of glucose in nature. L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. The unspecified form of glucose is commonly supplied as an injection for nutritional supplementation or metabolic disorders where glucose levels are improperly regulated. Glucose is listed on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

Indication: Glucose pharmaceutical formulations (oral tablets, injections) are indicated for caloric supply and carbohydrate supplementation in case of nutrient deprivation. It is also used for metabolic disorders such as hypoglycemia.

Associated Conditions: Dehydration, End-stage Chronic Kidney Failure, Fluid Loss, Hypoglycemia, Local Anaesthesia therapy, Potassium imbalance

Associated Therapies: Continuous Renal Replacement Therapy, Fluid replacement therapy, Haemodiafiltration, Haemofiltration, Hemodialysis Treatment, Oral rehydration therapy, Parenteral Nutrition, Peritoneal dialysis therapy, Fluid and electrolyte maintenance therapy

Human Models of Selective Insulin Resistance: Pancreatic Clamp

Phase 1

Not yet recruiting

Conditions: Insulin Resistance
Hyperinsulinemia
Metabolic Dysfunction Associated Steatotic Liver Disease
Non-Alcoholic Fatty Liver Disease
Prediabetic State
Obesity

Interventions: Drug: Insulin human
Drug: Octreotide Acetate
Drug: Glucagon
Drug: Growth Hormone, Human
Drug: 20% D-glucose (aq)
Diagnostic Test: [6,6-2H2] D-glucose
Diagnostic Test: [1-13C1] sodium acetate
Dietary Supplement: Nestle BOOST Plus
Dietary Supplement: KIND Bar
Device: Harvard Apparatus PHD ULTRA CP syringe pump
Device: Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate Analyzer

Locations: 🇺🇸
Columbia University Irving Medical Center, New York, New York, United States

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