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D-glucose

Generic Name
D-glucose
Brand Names
As 3, Cpda-1 Blood Collection System, Dextrose and Electrolyte No. 75, Dianeal Low Calcium 1.5, Dianeal Pd-2/1.5, Ionosol-MB, Isolyte P, Leukotrap, Normosol-M, Plasma-lyte 148 In 5 % Dextrose, Prismasol
Drug Type
Small Molecule
Chemical Formula
C6H12O6
CAS Number
50-99-7
Unique Ingredient Identifier
5SL0G7R0OK

Overview

Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through aerobic or anaerobic respiration and fermentation. It is primarily stored as starch in plants and glycogen in animals to be used in various metabolic processes in the cellular level. Its aldohexose stereoisomer, dextrose or D-glucose, is the most commonly occurring isomer of glucose in nature. L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. The unspecified form of glucose is commonly supplied as an injection for nutritional supplementation or metabolic disorders where glucose levels are improperly regulated. Glucose is listed on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

Background

Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through aerobic or anaerobic respiration and fermentation. It is primarily stored as starch in plants and glycogen in animals to be used in various metabolic processes in the cellular level. Its aldohexose stereoisomer, dextrose or D-glucose, is the most commonly occurring isomer of glucose in nature. L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. The unspecified form of glucose is commonly supplied as an injection for nutritional supplementation or metabolic disorders where glucose levels are improperly regulated. Glucose is listed on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

Indication

Glucose pharmaceutical formulations (oral tablets, injections) are indicated for caloric supply and carbohydrate supplementation in case of nutrient deprivation. It is also used for metabolic disorders such as hypoglycemia.

Associated Conditions

  • Dehydration
  • End-stage Chronic Kidney Failure
  • Fluid Loss
  • Hypoglycemia
  • Local Anaesthesia therapy
  • Potassium imbalance

Clinical Trials

Phase 1
Withdrawn
Posted: 2023/11/13
Phase 1
Suspended
Posted: 2023/02/13
Early Phase 1
Posted: 2021/06/30
Sponsor:
Zhujiang Hospital

FDA Approved Products

Elliotts B
Manufacturer:Lukare Medical, LLC
Route:INTRATHECAL
Strength:8 mg in 10 mL
Approved: 2018/11/16
NDC:55792-007
Haemonetics Anticoagulant Citrate Phosphate Double Dextrose Solution (CP2D)
Manufacturer:Haemonetics Corporation
Route:EXTRACORPOREAL
Strength:464 mg in 1 mL
Approved: 2020/09/30
NDC:57826-455
Elliotts B
Manufacturer:QOL Medical, LLC
Route:INTRATHECAL
Strength:8 mg in 10 mL
Approved: 2012/03/20
NDC:67871-007
Haemonetics Additive Solution Formula 3 (AS-3)
Manufacturer:Haemonetics Corporation
Route:EXTRACORPOREAL
Strength:100 mg in 1 mL
Approved: 2020/09/11
NDC:57826-460

Singapore Approved Products

DIANEAL PD-2 PERITONEAL DIALYSIS SOLUTION WITH 4.25% DEXTROSE
Manufacturer:BAXTER HEALTHCARE SA, SINGAPORE BRANCH, BAXTER HEALTHCARE CORPN
Form:SOLUTION, STERILE
Strength:4.25 g/100 ml
Online:Yes
Approved: 1991/03/27
Approval:SIN05589P
DIANEAL LOW CALCIUM (2.5 mEq/l) PERITONEAL DIALYSIS SOLUTION WITH 1.5% DEXTROSE
Manufacturer:BAXTER HEALTHCARE SA, SINGAPORE BRANCH, BAXTER HEALTHCARE CORPORATION
Form:SOLUTION, STERILE
Strength:1.5 g/100 ml
Online:Yes
Approved: 1991/10/14
Approval:SIN06627P
DEXTROSE INJECTION USP 70%
Manufacturer:BAXTER HEALTHCARE CORPORATION
Form:INJECTION
Strength:70 g/100 ml
Online:Yes
Approved: 1998/10/06
Approval:SIN10166P
DIANEAL PD-2 PERITONEAL DIALYSIS SOLUTION WITH 1.5% DEXTROSE
Manufacturer:BAXTER HEALTHCARE SA, SINGAPORE BRANCH, BAXTER HEALTHCARE CORPN
Form:SOLUTION, STERILE
Strength:1.5 g/100 ml
Online:Yes
Approved: 1991/03/27
Approval:SIN05590P
DEXTROSE 5% AND SODIUM CHLORIDE 0.2% INJECTION USP
Manufacturer:BAXTER HEALTHCARE CORPORATION
Form:INJECTION
Strength:5 g/100 ml
Online:Yes
Approved: 1991/04/08
Approval:SIN05730P

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