Mepivacaine

Overview

A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)

Indication

For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.

Associated Conditions

Anaemia vitamin B6 deficiency
Anemia
Blood Loss Anemia
Diabetic Peripheral Neuropathy (DPN)

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Hemodynamic Effects of Different Vasoconstrictors in Mandibular Exodontia	2025/06/10	NCT07013071	Phase 4	Completed	King Abdulaziz University
Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA	2024/03/04	NCT06291727	Phase 4	Recruiting	Prisma Health-Upstate
Avoid With Locoregional Analgesia Persistant Postoperative Pain In Children	2024/02/21	NCT06271174	Phase 3	Recruiting	Nantes University Hospital
Spinal Hypobaric Local Anesthetic Study	2023/12/12	NCT06166394	N/A	Completed	University Health Network, Toronto
Photobiomodulation for Controlling Pre-Local Anesthetic Injection Pain	2023/11/13	NCT06128590	Not Applicable	Completed	University of Nove de Julho
Combination of Buffered Anesthetic to Treat Mandibular Molars	2023/09/21	NCT06047366	Phase 4	Terminated	Indiana University
Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers	2023/08/22	NCT06005480	Phase 1	Completed	Brigham and Women's Hospital
Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty	2023/08/08	NCT05980546	Phase 4	Recruiting	Hospital for Special Surgery, New York
Articaine Efficacy and Safety for 3 Years Old Children	2023/05/03	NCT05839548	Phase 3	Active, not recruiting	Qassim Health Cluster
Comparing General Anesthesia With Single Injection Peribulbar Block With 3 Different Drugs	2023/02/14	NCT05728151	Not Applicable	Completed	Research Institute of Ophthalmology, Egypt

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Polocaine-MPF	Fresenius Kabi USA, LLC	63323-294	EPIDURAL, INFILTRATION	20 mg in 1 mL	8/12/2019
Polocaine	Fresenius Kabi USA, LLC	63323-283	INFILTRATION	10 mg in 1 mL	8/12/2019
Carbocaine with Neo-Cobefrin	Caresteam Health, Inc.	31382-931	SUBCUTANEOUS	20 mg in 1 mL	12/12/2017
Mepivacaine	Darby Dental Supply, LLC	66467-9760	SUBMUCOSAL	30 mg in 1 mL	2/21/2024
Polocaine	Dentsply Pharmaceutical	66312-441	SUBMUCOSAL	30 mg in 1 mL	2/21/2024
POLOCAINE (MEPIVACAINE HCl)	HF Acquisition Co LLC, DBA HealthFirst	51662-1535	INFILTRATION	20 mg in 1 mL	1/30/2024
Polocaine	A-S Medication Solutions	50090-4517	INFILTRATION	10 mg in 1 mL	8/12/2019
Scandonest 3% Plain	Septodont, Inc.	0362-1098	SUBMUCOSAL	30 mg in 1 mL	2/21/2024
Carbocaine	Caresteam Health, Inc.	31382-753	SUBCUTANEOUS	30 mg in 1 mL	12/12/2017
Polocaine	A-S Medication Solutions	50090-4408	INFILTRATION	20 mg in 1 mL	8/12/2019

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
ISOCAINE (MEPIVACAINE HCL) INJECTION 3%	Novocol Pharmaceutical of Canada, Inc.	SIN14649P	INJECTION	30 mg/mL	10/24/2014
SCANDONEST INJECTION 3% (WITHOUT VASO-CONSTRICTOR)	SPECIALITES SEPTODONT	SIN07075P	INJECTION	54 mg/1.8 ml	6/24/1992
MEPIVASTESIN INJECTION 30 mg/ml	3M Deutschland GmbH	SIN06179P	INJECTION	30 mg/ml	5/23/1991
SCANDONEST 2% SPECIAL INJECTION	SPECIALITES SEPTODONT	SIN07074P	INJECTION	0.020g/ml	6/24/1992

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
SCANDONEST 3% 66mg/2.2mL injection	49313	Specialites Septodont Pty Ltd	Medicine	A	7/13/1994
SCANDONEST 3% 54mg/1.8mL injection	49310	Specialites Septodont Pty Ltd	Medicine	A	7/13/1994
ATO MEPIVACAINE 3% mepivacaine hydrochloride 66mg/2.2mL injection cartridge	150494	Specialites Septodont Pty Ltd	Medicine	A	9/19/2008

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
2% POLOCAINE DENTAL WITH LEVONORDEFRIN 1:20,000	dentsply canada limited	00874639	Solution - Block/Infiltration	20 MG / ML	12/31/1990
CARBOCAINE 1%	Pfizer Canada Ulc	02241999	Solution - Intracaudal , Epidural	10 MG / ML	6/1/2001
ISOCAINE HCL INJ 2%	novocol pharmaceutical of canada inc	00393711	Solution - Block/Infiltration	20 MG / ML	12/31/1977
CARBOCAINE 1%	Pfizer Canada Ulc	02242000	Solution - Block/Infiltration	10 MG / ML	7/15/2001
ISOCAINE HCL INJ 3%	novocol pharmaceutical of canada inc	00364304	Solution - Block/Infiltration	30 MG / ML	12/31/1977
CARBOCAINE 2%	Pfizer Canada Ulc	02242001	Solution - Epidural , Intracaudal	20 MG / ML	7/15/2001
SCANDONEST 2% SPECIAL INJ	Septodont	00479942	Liquid - Block/Infiltration	20 MG / ML	12/31/1980
3% POLOCAINE DENTAL	dentsply canada limited	02330733	Liquid - Block/Infiltration	30 MG / ML	10/19/2009
CARBOCAINE INJ LIQ 20MG/ML	sterling winthrop inc.	01959913	Liquid - Intraspinal	20 MG / ML	12/31/1992
CARBOCAINE 3%	Septodont	02474174	Solution - Block/Infiltration	30 MG / ML	5/7/2019

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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