Mepivacaine
- Generic Name
- Mepivacaine
- Brand Names
- Carbocaine, Carbocaine With Neocobefrin, Isocaine, Isocaine With Levonordefrin, Polocaine, Scandonest, Scandonest L, Scandonest Plain
- Drug Type
- Small Molecule
- Chemical Formula
- C15H22N2O
- CAS Number
- 96-88-8
- Unique Ingredient Identifier
- B6E06QE59J
- Background
A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
- Indication
For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.
- Associated Conditions
- Anaemia vitamin B6 deficiency, Anemia, Blood Loss Anemia, Diabetic Peripheral Neuropathy (DPN)
- Associated Therapies
- Local Anaesthesia therapy, Regional nerve block therapy, Lumbar epidural anesthesia therapy
Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA
- Conditions
- Arthroplasty, Replacement, KneeAnesthesia, Spinal
- Interventions
- First Posted Date
- 2024-03-04
- Last Posted Date
- 2024-08-20
- Lead Sponsor
- Prisma Health-Upstate
- Target Recruit Count
- 138
- Registration Number
- NCT06291727
- Locations
- 🇺🇸
Prisma Health Patewood Hospital, Greenville, South Carolina, United States
Avoid With Locoregional Analgesia Persistant Postoperative Pain In Children
- Conditions
- Persistent Postoperative Pain
- Interventions
- Drug: Profofol and/or Suxaméthonium and/or Sévoflurane
- First Posted Date
- 2024-02-21
- Last Posted Date
- 2024-06-12
- Lead Sponsor
- Nantes University Hospital
- Target Recruit Count
- 208
- Registration Number
- NCT06271174
- Locations
- 🇫🇷
CHU Nantes, Nantes, France
Spinal Hypobaric Local Anesthetic Study
- Conditions
- Anesthesia, Local
- Interventions
- Drug: Spinal hypobaric Bupivacaine Local Anesthetic Injection
- First Posted Date
- 2023-12-12
- Last Posted Date
- 2025-03-28
- Lead Sponsor
- University Health Network, Toronto
- Target Recruit Count
- 60
- Registration Number
- NCT06166394
- Locations
- 🇨🇦
Toronto Western Hospital, Toronto, Ontario, Canada
Photobiomodulation for Controlling Pre-Local Anesthetic Injection Pain
- Conditions
- Fear Needles
- Interventions
- Device: PhotobiomodulationDevice: Photobiomodulation simulation
- First Posted Date
- 2023-11-13
- Last Posted Date
- 2024-07-18
- Lead Sponsor
- University of Nove de Julho
- Target Recruit Count
- 50
- Registration Number
- NCT06128590
- Locations
- 🇧🇷
Anna Carolina R.T. Horliana, São Paulo, SP, Brazil
Combination of Buffered Anesthetic to Treat Mandibular Molars
- Conditions
- Symptomatic Irreversible Pulpitis
- Interventions
- First Posted Date
- 2023-09-21
- Last Posted Date
- 2025-05-13
- Lead Sponsor
- Indiana University
- Target Recruit Count
- 40
- Registration Number
- NCT06047366
- Locations
- 🇺🇸
ndiana University School of Dentistry Graduate Endodontics Dept., Indianapolis, Indiana, United States
Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers
- Conditions
- Regional Anesthesia MorbidityPain, AcuteHealthy
- Interventions
- First Posted Date
- 2023-08-22
- Last Posted Date
- 2024-06-17
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 58
- Registration Number
- NCT06005480
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty
- Conditions
- Genicular Nerve BlockOpioid UseTotal Knee Replacement
- Interventions
- First Posted Date
- 2023-08-08
- Last Posted Date
- 2024-12-27
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 244
- Registration Number
- NCT05980546
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
Articaine Efficacy and Safety for 3 Years Old Children
- Conditions
- Dental DiseasesPulp Disease, DentalBehavior, ChildDental Caries in Children
- First Posted Date
- 2023-05-03
- Last Posted Date
- 2024-12-27
- Lead Sponsor
- Qassim Health Cluster
- Target Recruit Count
- 200
- Registration Number
- NCT05839548
- Locations
- 🇸🇦
Qassim University, Burayadh, Qassim, Saudi Arabia
Comparing General Anesthesia With Single Injection Peribulbar Block With 3 Different Drugs
- Conditions
- Pediatric Squint Surgeries
- Interventions
- First Posted Date
- 2023-02-14
- Last Posted Date
- 2025-04-23
- Lead Sponsor
- Research Institute of Ophthalmology, Egypt
- Target Recruit Count
- 55
- Registration Number
- NCT05728151
- Locations
- 🇪🇬
Research Institute of Ophthalmology, Giza, Egypt
Mepivacaine Versus Bupivacaine Onset Time in Ultrasound-guided Ankle Blocks
- First Posted Date
- 2022-06-21
- Last Posted Date
- 2024-03-13
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 50
- Registration Number
- NCT05425979
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.