Overview
A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Background
A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Indication
For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.
Associated Conditions
- Anaemia vitamin B6 deficiency
- Anemia
- Blood Loss Anemia
- Diabetic Peripheral Neuropathy (DPN)
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/06/10 | Phase 4 | Completed | |||
2024/03/04 | Phase 4 | Recruiting | |||
2024/02/21 | Phase 3 | Recruiting | |||
2023/12/12 | N/A | Completed | |||
2023/11/13 | Not Applicable | Completed | |||
2023/09/21 | Phase 4 | Terminated | |||
2023/08/22 | Phase 1 | Completed | |||
2023/08/08 | Phase 4 | Recruiting | Hospital for Special Surgery, New York | ||
2023/05/03 | Phase 3 | Active, not recruiting | Qassim Health Cluster | ||
2023/02/14 | Not Applicable | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Fresenius Kabi USA, LLC | 63323-294 | EPIDURAL, INFILTRATION | 20 mg in 1 mL | 8/12/2019 | |
| Fresenius Kabi USA, LLC | 63323-283 | INFILTRATION | 10 mg in 1 mL | 8/12/2019 | |
| Caresteam Health, Inc. | 31382-931 | SUBCUTANEOUS | 20 mg in 1 mL | 12/12/2017 | |
| Darby Dental Supply, LLC | 66467-9760 | SUBMUCOSAL | 30 mg in 1 mL | 2/21/2024 | |
| Dentsply Pharmaceutical | 66312-441 | SUBMUCOSAL | 30 mg in 1 mL | 2/21/2024 | |
| HF Acquisition Co LLC, DBA HealthFirst | 51662-1535 | INFILTRATION | 20 mg in 1 mL | 1/30/2024 | |
| A-S Medication Solutions | 50090-4517 | INFILTRATION | 10 mg in 1 mL | 8/12/2019 | |
| Septodont, Inc. | 0362-1098 | SUBMUCOSAL | 30 mg in 1 mL | 2/21/2024 | |
| Caresteam Health, Inc. | 31382-753 | SUBCUTANEOUS | 30 mg in 1 mL | 12/12/2017 | |
| A-S Medication Solutions | 50090-4408 | INFILTRATION | 20 mg in 1 mL | 8/12/2019 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| ISOCAINE (MEPIVACAINE HCL) INJECTION 3% | Novocol Pharmaceutical of Canada, Inc. | SIN14649P | INJECTION | 30 mg/mL | 10/24/2014 |
| SCANDONEST INJECTION 3% (WITHOUT VASO-CONSTRICTOR) | SPECIALITES SEPTODONT | SIN07075P | INJECTION | 54 mg/1.8 ml | 6/24/1992 |
| MEPIVASTESIN INJECTION 30 mg/ml | 3M Deutschland GmbH | SIN06179P | INJECTION | 30 mg/ml | 5/23/1991 |
| SCANDONEST 2% SPECIAL INJECTION | SPECIALITES SEPTODONT | SIN07074P | INJECTION | 0.020g/ml | 6/24/1992 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Mepivacaine Hydrochloride Injection | 国药准字H20244513 | 化学药品 | 注射剂 | 7/30/2024 | |
| Mepivacaine Hydrochloride Injection | 国药准字H20213810 | 化学药品 | 注射剂 | 10/26/2021 | |
| Mepivacaine Hydrochloride Injection | 国药准字HJ20181204 | 化学药品 | 注射剂 | 3/15/2023 | |
| Mepivacaine Hydrochloride Injection | 国药准字H20249473 | 化学药品 | 注射剂 | 12/1/2024 | |
| Mepivacaine Hydrochloride Injection | 国药准字H20110062 | 化学药品 | 注射剂 | 7/22/2020 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| SCANDONEST 3% 66mg/2.2mL injection | 49313 | Medicine | A | 7/13/1994 | |
| SCANDONEST 3% 54mg/1.8mL injection | 49310 | Medicine | A | 7/13/1994 | |
| ATO MEPIVACAINE 3% mepivacaine hydrochloride 66mg/2.2mL injection cartridge | 150494 | Medicine | A | 9/19/2008 |