Mepivacaine

Generic Name: Mepivacaine

Brand Names: Carbocaine, Carbocaine With Neocobefrin, Isocaine, Isocaine With Levonordefrin, Polocaine, Scandonest, Scandonest L, Scandonest Plain

Drug Type: Small Molecule

Chemical Formula: C_₁₅H_₂₂N_₂O

CAS Number: 96-88-8

Unique Ingredient Identifier: B6E06QE59J

Background: A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)

Indication: For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.

Associated Conditions: Anaemia vitamin B6 deficiency, Anemia, Blood Loss Anemia, Diabetic Peripheral Neuropathy (DPN)

Associated Therapies: Local Anaesthesia therapy, Regional nerve block therapy, Lumbar epidural anesthesia therapy

Clinical Trials

Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA

Phase 4

Recruiting

Conditions: Arthroplasty, Replacement, Knee
Anesthesia, Spinal

Interventions: Drug: Bupivacaine
Drug: Mepivacaine

First Posted Date: 2024-03-04

Last Posted Date: 2024-08-20

Lead Sponsor: Prisma Health-Upstate

Target Recruit Count: 138

Registration Number: NCT06291727

Locations: 🇺🇸
Prisma Health Patewood Hospital, Greenville, South Carolina, United States

Avoid With Locoregional Analgesia Persistant Postoperative Pain In Children

Phase 3

Recruiting

Conditions: Persistent Postoperative Pain

Interventions: Drug: Carbocaine
Drug: Profofol and/or Suxaméthonium and/or Sévoflurane

First Posted Date: 2024-02-21

Last Posted Date: 2024-06-12

Lead Sponsor: Nantes University Hospital

Target Recruit Count: 208

Registration Number: NCT06271174

Locations: 🇫🇷
CHU Nantes, Nantes, France

Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers

Phase 1

Completed

Conditions: Regional Anesthesia Morbidity
Pain, Acute
Healthy

Interventions: Drug: Mepivacaine

First Posted Date: 2023-08-22

Last Posted Date: 2024-06-17

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 58

Registration Number: NCT06005480

Locations: 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States

Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty

Phase 4

Recruiting

Conditions: Genicular Nerve Block
Opioid Use
Total Knee Replacement

Interventions: Drug: Bupivacaine Injection
Drug: Dexamethasone injection
Drug: Fentanyl
Drug: Mepivacaine

First Posted Date: 2023-08-08

Last Posted Date: 2024-05-01

Lead Sponsor: Hospital for Special Surgery, New York

Target Recruit Count: 244

Registration Number: NCT05980546

Locations: 🇺🇸
Hospital for Special Surgery, New York, New York, United States

Comparing General Anesthesia With Single Injection Peribulbar Block With 3 Different Drugs

Not Applicable

Recruiting

Conditions: Pediatric Squint Surgeries

Interventions: Drug: Articaine and Epinephrine Only Product
Drug: levobupivacaine
Drug: mepivacaine

First Posted Date: 2023-02-14

Last Posted Date: 2023-03-06

Lead Sponsor: Research Institute of Ophthalmology, Egypt

Target Recruit Count: 55

Registration Number: NCT05728151

Locations: 🇪🇬
Research Institute of Ophthalmology, Giza, Egypt

Mepivacaine Versus Bupivacaine Onset Time in Ultrasound-guided Ankle Blocks

Phase 4

Conditions: Ankle Block
Foot Surgery

Interventions: Drug: Mepivacaine
Drug: Bupivacaine

First Posted Date: 2022-06-21

Last Posted Date: 2024-03-13

Lead Sponsor: Mayo Clinic

Target Recruit Count: 50

Registration Number: NCT05425979

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Uterovaginal Plexus Block With Articaine for Intrauterine Device Placement Patients Who Are Indicated for the Use of Copper IUD as a Contraceptive Method Will be Invited to Participate in This Research.

Phase 4

Conditions: Contraception
IUD
Anesthesia, Local

Interventions: Drug: Articaine Hydrochloride 40 MG/ML
Drug: Mepivacaine

First Posted Date: 2022-02-23

Last Posted Date: 2022-02-23

Lead Sponsor: Universidade do Vale do Sapucai

Target Recruit Count: 240

Registration Number: NCT05252117

Locations: 🇧🇷
Universidade do Vale do Sapucaí, Pouso Alegre, Minas Gerais, Brazil

Anaesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine With Symptomatic Irreversible Pulpitis

Not Applicable

Completed

Conditions: Symptomatic Irreversible Pulpitis

Interventions: Drug: Mepivacaine
Drug: Articaine

First Posted Date: 2021-03-30

Last Posted Date: 2021-08-02

Lead Sponsor: Cairo University

Target Recruit Count: 330

Registration Number: NCT04822415

Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension

Phase 4

Recruiting

Conditions: Intraoperative Hypertension
Ankle Fusion
Tourniquet Hypertension
Total Ankle Arthroplasty

Interventions: Drug: Saline
Drug: Mepivacaine
Procedure: Perifemoral Injection of Local Anesthetic

First Posted Date: 2020-07-01

Last Posted Date: 2024-01-29

Lead Sponsor: Duke University

Target Recruit Count: 40

Registration Number: NCT04454203

Locations: 🇺🇸
Duke University Hospital, Durham, North Carolina, United States

Regional Anesthesia in Total Hip and Knee Arthroplasty

Phase 4

Conditions: Knee Osteoarthritis
Hip Osteoarthritis

Interventions: Drug: Bupivacaine
Drug: Ropivacaine
Drug: Mepivacaine

First Posted Date: 2020-02-06

Last Posted Date: 2022-08-08

Lead Sponsor: Ottawa Hospital Research Institute

Target Recruit Count: 135

Registration Number: NCT04257682

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