Betamethasone

Generic Name: Betamethasone

Brand Names: Betaderm, Betaloan Suik, Beteflam, Celestoderm, Celestone Soluspan, Dermacinrx Therazole Pak, Diprolene, Diprosalic, Diprosone, Dovobet, Enstilar, Fucibet, Lotriderm, Lotrisone, Luxiq, Marbeta, Rivasone, Rolene, Rosone, Sernivo, Taclonex, Valisone-G, Wynzora

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 378-44-9

Unique Ingredient Identifier: 9842X06Q6M

Background: Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.

Indication: As a member of the corticosteroid family, betamethasone is indicated for the treatment of several inflammatory conditions. As topical monotherapy, betamethasone is indicated to relieve pruritic and inflammatory symptoms of corticosteroid-responsive-dermatoses. Betamethasone can be used topically in combination with a vitamin D analog such as calcipotriene to treat plaque psoriasis. The corticosteroid is also available as an injectable suspension and can be used to manage a range of inflammatory conditions including endocrine disorders, gastrointestinal disorders, and rheumatic disorders among other conditions.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Atopic Dermatitis, Berylliosis, Blepharitis allergic, Blepharoconjunctivitis, Bullous dermatitis herpetiformis, Bursitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Dermatomyositis (DM), Dermatosis, Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Episcleritis, External ear inflammation, Eye allergy, Hypercalcemia of Malignancy, Inflammatory Reaction of the ear, Iridocyclitis, Iritis, Itching caused by Allergies, Keloids Scars, Keratitis, Keratitis interstitial, Keratoconjunctivitis, Leukemias, Lichen Planus (LP), Lichen simplex chronicus, Lupus Erythematosus, Lymphoma, Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Nephrotic Syndrome, Ocular Inflammation, Ocular injuries, Ophthalmia, Sympathetic, Pemphigus, Plaque psoriasis of the body, Plaque psoriasis of the scalp, Polymyositis, Post Surgical Ocular Inflammation, Pruritus, Psoriasis, Psoriasis Vulgaris (Plaque Psoriasis), Psoriatic Arthritis, Psoriatic plaque, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Scleritis, Secondary thrombocytopenia, Severe Asthma, Severe Atopic Dermatitis, Skin Infections, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Verrucous Lichen Planus (LP), Acquired immune hemolytic anemia, Acute nonspecific tenosynovitis, Acute rheumatic carditis, Bacterial blepharitis, Corticosteroid-responsive dermatoses, Eczematous rash, Exfoliative erythroderma, Granuloma annulare lesions, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Allergic rhinitis, Severe Contact dermatitis, Severe Serum sickness, Severe Transfusion Reactions, Severe drug hypersensitivity reactions, Superficial ocular infections, Symptomatic Sarcoidosis, Synovitis of osteoarthritis

Associated Therapies: -

Clinical Trials

Efficacy of Antenatal Steroids in Reducing Respiratory Morbidities in Late Preterm Infants

Phase 2

Conditions: Respiratory Distress Syndrome, Newborn
Transient Tachypnea of the Newborn

Interventions: Drug: Betamethasone
Other: Normal Saline

First Posted Date: 2010-09-22

Last Posted Date: 2011-06-23

Lead Sponsor: American University of Beirut Medical Center

Target Recruit Count: 700

Registration Number: NCT01206946

Locations: 🇱🇧
American University of Beirut Medical Center, Beirut, Lebanon
🇱🇧
Bahman Hospital, Beirut, Lebanon
🇱🇧
Rafik Hariri University Hospital, Beirut, Lebanon

and more 2 locations

Efficacy of Micro-Pulse Steroid Therapy as Induction Therapy in Patients With Polymyalgia Rheumatica

Not Applicable

Conditions: Polymyalgia Rheumatica

Interventions: Drug: Betamethasone
Drug: isotonic sodium chloride solution (placebo)

First Posted Date: 2009-09-23

Last Posted Date: 2010-07-20

Lead Sponsor: Bnai Zion Medical Center

Target Recruit Count: 20

Registration Number: NCT00982332

Locations: 🇮🇱
Bnai Zion Medical Center, Haifa, Israel

Efficacy & Safety of Loratadine-Betamethasone Oral Solution for Treatment of Severe Perennial Allergic Rhinitis in Children (Study P03428)

Phase 4

Completed

Conditions: Rhinitis

Interventions: Drug: Loratadine
Drug: Betamethasone

First Posted Date: 2009-08-21

Last Posted Date: 2015-04-21

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 100

Registration Number: NCT00963573

Mild Versus Potent Corticosteroids as Treatment for Phimosis in Children

Phase 4

Withdrawn

Conditions: Phimosis

Interventions: Drug: hydrocortisone
Drug: Betamethasone

First Posted Date: 2009-07-07

Last Posted Date: 2015-07-30

Lead Sponsor: Chelsea and Westminster NHS Foundation Trust

Registration Number: NCT00933023

Locations: 🇬🇧
Chelsea and Westminster Hospital, London, United Kingdom

Study About Preventive Treatment of Folliculitis Induced by Epidermal Growth Factor Receptor Inhibitors

Phase 2

Completed

Conditions: Metastatic Colorectal Cancer
Non-Small-Cell Lung Carcinoma

Interventions: Drug: Diprosone

First Posted Date: 2009-06-01

Last Posted Date: 2012-07-31

Lead Sponsor: Centre Oscar Lambret

Target Recruit Count: 30

Registration Number: NCT00910676

Locations: 🇫🇷
Centre Oscar Lambret, Lille, France
🇫🇷
Centre Hospitalier Regional, Lille, France
🇫🇷
Centre Hospitalier Régional, Lille, France

Prolotherapy Versus Steroids for Thumb Carpo-metacarpal Joint Arthritis

Not Applicable

Terminated

Conditions: Thumb Carpometacarpal Joint Osteoarthritis

Interventions: Drug: Prolotherapy (10% dextrose solution)
Drug: Betamethasone

First Posted Date: 2008-05-29

Last Posted Date: 2012-08-30

Lead Sponsor: Mayo Clinic

Target Recruit Count: 2

Registration Number: NCT00685880

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

Antenatal Corticoid Therapy for Late Preterm Babies

Not Applicable

Completed

Conditions: Transient Tachypnea
Hyaline Membrane Disease

Interventions: Drug: Betamethasone

First Posted Date: 2008-05-09

Last Posted Date: 2010-06-09

Lead Sponsor: Instituto Materno Infantil Prof. Fernando Figueira

Target Recruit Count: 320

Registration Number: NCT00675246

Locations: 🇧🇷
Instituto Materno Infantil Prof. Fernando Figueira, Recife, Pernambuco, Brazil

Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM)

Phase 1

Terminated

Conditions: Congenital Cystic Adenomatoid Malformation

Interventions: Drug: Placebo
Drug: Betamethasone

First Posted Date: 2008-05-02

Last Posted Date: 2015-03-30

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 1

Registration Number: NCT00670956

Locations: 🇺🇸
University of California, San Francisco Fetal Treatment Center, San Francisco, California, United States
🇺🇸
Cincinnati Children's Hospital, Cincinnati, Ohio, United States
🇺🇸
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

Rescue Antenatal Steroids and Pulmonary Function Tests in Preterm Infants

Not Applicable

Completed

Conditions: Respiratory Compliance
Functional Residual Capacity
Pulmonary Function Testing

Interventions: Drug: betamethasone
Drug: placebo

First Posted Date: 2008-04-30

Last Posted Date: 2019-02-22

Lead Sponsor: Oregon Health and Science University

Target Recruit Count: 85

Registration Number: NCT00669383

Locations: 🇺🇸
Oregon Health & Science University, Portland, Oregon, United States

A Randomised Trial of a Moisturising Cream in Preventing Recurrence of Hand Eczema

Phase 4

Completed

Conditions: Hand Eczema

Interventions: Drug: Urea
Drug: betamethasone valerate

First Posted Date: 2007-12-19

Last Posted Date: 2008-10-13

Lead Sponsor: ACO Hud Nordic AB

Target Recruit Count: 53

Registration Number: NCT00576550

Locations: 🇳🇴
Medi 3 Innlandet, Hamar, Norway
🇳🇴
Colosseumklinikken, Oslo, Norway
🇳🇴
Dr Funks hudklinikk, Oslo, Norway

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