Betamethasone

Generic Name: Betamethasone

Brand Names: Betaderm, Betaloan Suik, Beteflam, Celestoderm, Celestone Soluspan, Dermacinrx Therazole Pak, Diprolene, Diprosalic, Diprosone, Dovobet, Enstilar, Fucibet, Lotriderm, Lotrisone, Luxiq, Marbeta, Rivasone, Rolene, Rosone, Sernivo, Taclonex, Valisone-G, Wynzora

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 378-44-9

Unique Ingredient Identifier: 9842X06Q6M

Background: Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.

Indication: As a member of the corticosteroid family, betamethasone is indicated for the treatment of several inflammatory conditions. As topical monotherapy, betamethasone is indicated to relieve pruritic and inflammatory symptoms of corticosteroid-responsive-dermatoses. Betamethasone can be used topically in combination with a vitamin D analog such as calcipotriene to treat plaque psoriasis. The corticosteroid is also available as an injectable suspension and can be used to manage a range of inflammatory conditions including endocrine disorders, gastrointestinal disorders, and rheumatic disorders among other conditions.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Atopic Dermatitis, Berylliosis, Blepharitis allergic, Blepharoconjunctivitis, Bullous dermatitis herpetiformis, Bursitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Dermatomyositis (DM), Dermatosis, Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Episcleritis, External ear inflammation, Eye allergy, Hypercalcemia of Malignancy, Inflammatory Reaction of the ear, Iridocyclitis, Iritis, Itching caused by Allergies, Keloids Scars, Keratitis, Keratitis interstitial, Keratoconjunctivitis, Leukemias, Lichen Planus (LP), Lichen simplex chronicus, Lupus Erythematosus, Lymphoma, Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Nephrotic Syndrome, Ocular Inflammation, Ocular injuries, Ophthalmia, Sympathetic, Pemphigus, Plaque psoriasis of the body, Plaque psoriasis of the scalp, Polymyositis, Post Surgical Ocular Inflammation, Pruritus, Psoriasis, Psoriasis Vulgaris (Plaque Psoriasis), Psoriatic Arthritis, Psoriatic plaque, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Scleritis, Secondary thrombocytopenia, Severe Asthma, Severe Atopic Dermatitis, Skin Infections, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Verrucous Lichen Planus (LP), Acquired immune hemolytic anemia, Acute nonspecific tenosynovitis, Acute rheumatic carditis, Bacterial blepharitis, Corticosteroid-responsive dermatoses, Eczematous rash, Exfoliative erythroderma, Granuloma annulare lesions, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Allergic rhinitis, Severe Contact dermatitis, Severe Serum sickness, Severe Transfusion Reactions, Severe drug hypersensitivity reactions, Superficial ocular infections, Symptomatic Sarcoidosis, Synovitis of osteoarthritis

Clinical Trials

Local Steroid Treatment for Idiopathic Granulomatous Mastitis (LSTIGM)

Phase 4

Conditions: Granulomatous Mastitis

Interventions: Drug: Compound Betamethasone Injection
Drug: Hydrocortisone Butyrate 0.1% Cream

First Posted Date: 2018-12-06

Last Posted Date: 2020-12-03

Lead Sponsor: Peking Union Medical College Hospital

Target Recruit Count: 100

Registration Number: NCT03766997

Locations: 🇨🇳
Department of Breast Surgery,Peking Union Medical College Hospital, Beijing, Beijing, China

Evaluation of the Vasoconstriction Properties of MC2-01 Cream

Phase 1

Completed

Conditions: Vasoconstriction

Interventions: Drug: Clobetasol Propionate 0.05% Lotion
Drug: Desonide 0.05% Cream
Drug: MC2-01 Cream
Drug: Betamethasone Dipropionate 0.05% Cream
Drug: Triamcinolone Acetonide 0.1% Cream
Drug: Vehicle
Drug: Hydrocortisone Butyrate 0.1% Cream

First Posted Date: 2018-11-29

Last Posted Date: 2020-01-09

Lead Sponsor: MC2 Therapeutics

Target Recruit Count: 36

Registration Number: NCT03758365

Locations: 🇫🇷
CPCAD, Nice, France

To Study Generic Calcipotriene and Betamethasone Dipropionate Topical Foam, 0.005%/0.064%, in the Treatment of Psoriasis Vulgaris (Plaque Psoriasis).

Phase 3

Completed

Conditions: Psoriasis Vulgaris

Interventions: Drug: Calcipotriene/ betamethasone dipropionate topical foam, 0.005%/0.064%
Other: Placebo of Calcipotriene/ betamethasone dipropionate topical foam
Drug: Enstilar® foam (LEO Pharma Inc.)

First Posted Date: 2018-11-06

Last Posted Date: 2020-08-19

Lead Sponsor: Glenmark Pharmaceuticals Ltd. India

Target Recruit Count: 494

Registration Number: NCT03731091

Locations: 🇺🇸
Investigational Site 20, Encinitas, California, United States
🇺🇸
Investigational Site 18, Fountain Valley, California, United States
🇺🇸
Investigational Site 28, New York, New York, United States

and more 27 locations

Treatment of FUS-Related ALS With Betamethasone - The TRANSLATE Study

Early Phase 1

Completed

Conditions: Familial Amyotrophic Lateral Sclerosis

Interventions: Drug: Betamethasone sodium phosphate/betamethasone acetate (Celestone® Soluspan®), 30 mg IM once a day for four days

First Posted Date: 2018-10-16

Last Posted Date: 2020-02-11

Lead Sponsor: Edward Kasaraskis

Target Recruit Count: 6

Registration Number: NCT03707795

Locations: 🇺🇸
University of Kentucky Medical Center, Lexington, Kentucky, United States

Antenatal Betamethasone and the Risk of Neonatal Hypoglycemia

Conditions: Hypoglycemia

Interventions: Drug: Betamethasone

First Posted Date: 2018-10-11

Last Posted Date: 2018-10-11

Lead Sponsor: Rambam Health Care Campus

Target Recruit Count: 1000

Registration Number: NCT03702959

Locations: 🇮🇱
Rambam health care campus, Haifa, Israel

Clinical Trial to Assess Safety, Tolerability and the Pharmacodynamic Effect of Different Concentrations of a New Anti-inflammatory Substance in Subjects With Chronic Plaque Psoriasis

Phase 1

Completed

Conditions: Psoriasis Vulgaris

Interventions: Drug: 0.1% betamethasone valerate ointment (class III steroid)
Drug: LEO 134310
Drug: LEO 134310 vehicle

First Posted Date: 2018-09-13

Last Posted Date: 2024-10-26

Lead Sponsor: LEO Pharma

Target Recruit Count: 13

Registration Number: NCT03669757

Locations: 🇩🇪
Investigational Site, Hamburg, Germany

India Dexamethasone and Betamethasone

Phase 1

Completed

Conditions: Preterm Birth
Antenatal Corticosteroids

Interventions: Drug: Dexamethasone 4 mg/ml
Drug: Celestone Soluspan 6Mg/Ml Suspension for Injection
Drug: Dexamethasone Oral Tablet
Drug: Betamethasone Oral Tablet
Drug: Betamethasone 4 mg/ml

First Posted Date: 2018-09-13

Last Posted Date: 2020-07-14

Lead Sponsor: Children's Hospital Medical Center, Cincinnati

Target Recruit Count: 48

Registration Number: NCT03668860

Locations: 🇮🇳
Syngene International Limited, Tower I, Bangalore, India

Safety, Tolerability And Efficacy Study Of Topical PF-06763809 In Subjects With Mild To Moderate Chronic Plaque Psoriasis

Phase 1

Completed

Conditions: Psoriasis

Interventions: Drug: PF-06763809
Other: Vehicle
Drug: Calcipotriene/calcipotriol
Drug: Betamethasone

First Posted Date: 2018-03-19

Last Posted Date: 2020-06-25

Lead Sponsor: Pfizer

Target Recruit Count: 18

Registration Number: NCT03469336

Locations: 🇩🇪
bioskin GmbH, Hamburg, Germany
🇩🇪
Rothaar Studien GmbH, Berlin, Germany

Effect of Antenatal Corticosteroids on Neonatal Morbidity.

Not Applicable

Completed

Conditions: Neonatal Respiratory Distress Syndrome

Interventions: Drug: Dexamethasone Sodium Phosphate Injection
Drug: Betamethasone Sodium Phosphate Injection (Medication)
Drug: Water for injection

First Posted Date: 2018-02-27

Last Posted Date: 2019-12-27

Lead Sponsor: Ahmadu Bello University Teaching Hospital

Target Recruit Count: 150

Registration Number: NCT03446937

Locations: 🇳🇬
Ahmadu Bello University Teaching Hospital Shika-Zaria, Zaria, Kaduna, Nigeria

Efficacy and Safety of Fucicort® Lipid Cream Compared to Combination Treatment With Fucidin® Cream Followed by Betamethasone (Lianbang Beisong®) Cream and Fucicort® Lipid Cream Vehicle in Clinically Infected Atopic Dermatitis/Eczema

Phase 3

Terminated

Conditions: Infected Atopic Dermatitis/Eczema

Interventions: Drug: Fucidin® cream
Drug: Fucicort® Lipid cream vehicle
Drug: Fucicort® Lipid cream
Drug: betamethasone (Lianbang Beisong®) cream

First Posted Date: 2018-01-10

Last Posted Date: 2025-02-24

Lead Sponsor: LEO Pharma

Target Recruit Count: 68

Registration Number: NCT03395132

Locations: 🇨🇳
The First Hospital of Dalian Medical University, Dalian, Liaoning, China
🇨🇳
Beijing Children's Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳
Peking Union Medical College Hospital, Beijing, Beijing, China

and more 12 locations

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