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Natural killer (NK) cells can be incubated with ‘feeder cells’ expressing certain cytokines prior to maturation to enhance their activity. In particular, incubation with IL-15 allows NK cells to lyse a broad range of fresh and cultured tumor targets that the cell is not normally sensitive to.
Natural killer (NK) cells can be incubated with ‘feeder cells’ expressing certain cytokines prior to maturation to enhance their activity. In particular, incubation with IL-15 allows NK cells to lyse a broad range of fresh and cultured tumor targets that the cell is not normally sensitive to.
IL-15 is a key cytokine in NK cell development and function; the IL-15 receptor (IL-15R) is constitutively expressed in both the CD56 and CD56 matured NK cells. Activation of the IL-15R involves 3 downstream pathways: JAK1/3/STAT3/5, P13K/Akt/mTOR, and Ras/Raf/MEK/ERK. It was shown that ‘priming’ NK-cells with IL-15 markedly enhanced anti-tumor responses which included cytotoxicity, degranulation, and cytokine production.
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
