Overview
Gamolenic acid, or gamma-linolenic acid (γ-Linolenic acid) or GLA, is an essential fatty acid (EFA) comprised of 18 carbon atoms with three double bonds that is most commonly found in human milk and other botanical sources . It is an omega-6 polyunsaturated fatty acid (PUFA) also referred to as 18:3n-6; 6,9,12-octadecatrienoic acid; and cis-6, cis-9, cis-12- octadecatrienoic acid . Gamolenic acid is produced minimally in the body as the delta 6-desaturase metabolite of Linolenic acid. It is converted to Dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. While Gamolenic acid is found naturally in the fatty acid fractions of some plant seed oils , Evening primrose oil and Borage oil are rich sources of gamolenic acid. Evening primrose oil has been investigated for clinical use in menopausal syndrome, diabetic neuropathy, and breast pain, where gamolenic acid is present at concentrations of 7-14% . Gamolenic acid may be found in over-the-counter dietary supplements. Gamolenic acid is also found in some fungal sources and also present naturally in the form of triglycerides . Various clinical indications of gamolenic acid have been studied, including rheumatoid arthritis, atopic eczema, acute respiratory distress syndrome, asthma, premenstrual syndrome, cardiovascular disease, ulcerative colitis, ADHD, cancer, osteoporosis, diabetic neuropathy, and insomnia.
Indication
Indicated as a dietary supplement for over-the-counter uses.
Associated Conditions
No associated conditions information available.
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
1999/10/19 | Not Applicable | Completed | FDA Office of Orphan Products Development |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| NUPRIMOL CAP | nu-life nutrition ltd. | 02010666 | Capsule - Oral | 45 MG | 9/15/1997 |
| ULTRAPRIM PRIMROSE OIL 1000MG CAP | gahler enterprises ltd. | 02016354 | Capsule - Oral | 100 MG | 12/31/1993 |
| PRO-GLA CAPS | professional health products | 00757551 | Capsule - Oral | 90 MG / CAP | 12/31/1989 |
| EVENING PRIMROSE OIL + VIT E CAP | bioforce canada inc. | 01983512 | Capsule - Oral | 45 MG | 12/31/1993 |
| BORAGE OIL CAPSULES | general nutrition canada inc. | 02183226 | Capsule - Oral | 258 MG | 10/15/2001 |
| BLACK CURRANT SEED OIL CAP | pure life international prods inc. | 02010070 | Capsule - Oral | 41 MG | 12/31/1993 |
| BORAGE OIL CAPSULES | bioforce canada inc. | 01986333 | Capsule - Oral | 125 MG | 12/31/1994 |
| EVENING PRIMROSE OIL 500MG CAPSULE | swiss herbal remedies ltd. | 02122731 | Capsule - Oral | 47.5 MG | 12/31/1985 |
| GLA 130 PRIMROSE OIL | seroyal international inc. | 02148137 | Capsule - Oral | 130 MG / CAP | 1/31/1996 |
| EVENING PRIMROSE OIL CAP | pure life international prods inc. | 01946846 | Capsule - Oral | 40 MG | 12/31/1992 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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