鬼臼毒素 (Condylox)

Podophyllotoxin

未知生产厂商

Podofilox is a topical agent used for the treatment of external genital warts and perianal warts.

生成 AI 研报

医学正文保留数据源原文，避免将未经专业审核的机器翻译呈现为临床事实。

概览

Podofilox is a topical agent used for the treatment of external genital warts and perianal warts.

作用机制

The exact mechanism of action is not well understood. It does appear, however, that it and its derivatives may bind and inhibit topoisomerase II during the late S and early G2 stage. The drug may bind and stabilize the temporary break caused by the enzyme. This disrupts the reparation of the break through which the double-stranded DNA passes, and consequently stops DNA unwinding and replication

适应症

For treatment of external genital warts (Condyloma acuminatum).

专利

每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。

Podophyllotoxin derivatives
US 7342114 B2申请人: CALIFORNIA PACIFIC MED CENTER优先权: 2003
US
6 件公开
PODOPHYLLOTOXIN COMPOSITIONS
EP 1251858 B1申请人: SUPRATEK PHARMA INC优先权: 2000
EP
US
WO
3 件公开
High-molecular weight conjugate of podophyllotoxins
US 8940332 B2申请人: KITAGAWA MASAYUKI优先权: 2006
CN
US
3 件公开
Podophyllotoxin derivatives and their use
- US 11186594 B2
  申请人: CALIFORNIA PACIFIC MEDICAL CENTER优先权: 2015
  CN
  US
  3 件公开
- US 10087194 B2
  申请人: CALIFORNIA PACIFIC MEDICAL CENTER优先权: 2015
  US
一种新型鬼臼毒素拼接抗肿瘤活性分子化合物及其制备方法及应用
CN 114539292 B申请人: 遵义医药高等专科学校优先权: 2022
CN
3 件公开
Aza-podophyllotoxin analogues as potential anti-cancer agents
US 11820779 B1申请人: UNIV KING FAISAL优先权: 2023
US
3 件公开
Sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof
US 9828386 B2申请人: UNIV HUBEI TECHNOLOGY优先权: 2013
CN
US
2 件公开
4β-amino substituted podophyllotoxin derivative and preparation method therefor and use thereof
US 11319328 B2申请人: TANG YAJIE优先权: 2017
CN
US
2 件公开
4-sulfur substituted podophyllotoxin derivative and preparation method therefor and use thereof
US 11242354 B2申请人: TANG YAJIE优先权: 2017
CN
US
2 件公开
4 beta-benseleno-4-desoxy-4-demethylpodophyllotoxin derivant
CN 1161358 C申请人: CHEN SHAOMING优先权: 2001
CN
2 件公开

药物

鬼臼毒素 (Condylox)

概览

作用机制

适应症

相关疾病

专利

Podophyllotoxin derivatives and their use