Avutometinib

Generic Name: Avutometinib

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₁₈FN_₅O_₅S

CAS Number: 946128-88-7

Unique Ingredient Identifier: D0D4252V97

Background: Avutometinib (RO-5126766 free base) is under investigation in clinical trial NCT03875820 (Phase I Trial of VS-6063 and RO5126766.).

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

Phase 1

Recruiting

Conditions: Melanoma

Interventions: Drug: Defactinib
Drug: Avutometinib
Drug: Encorafenib

First Posted Date: 2024-01-08

Last Posted Date: 2025-01-06

Lead Sponsor: University of Utah

Target Recruit Count: 33

Registration Number: NCT06194929

Locations: 🇺🇸
University of Iowa, Iowa City, Iowa, United States
🇺🇸
Huntsman Cancer Institute, Salt Lake City, Utah, United States

A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

Phase 3

Recruiting

Conditions: Low Grade Serous Ovarian Cancer

Interventions: Drug: avutometinib
Drug: Pegylated liposomal doxorubicin
Drug: Defactinib
Drug: Paclitaxel
Drug: Letrozole
Drug: Anastrozole

First Posted Date: 2023-10-10

Last Posted Date: 2024-12-31

Lead Sponsor: Verastem, Inc.

Target Recruit Count: 270

Registration Number: NCT06072781

Locations: 🇳🇿
Auckland City Hospital, Auckland, New Zealand
🇺🇸
HonorHealth, Phoenix, Arizona, United States
🇺🇸
University of Arkansas, Little Rock, Arkansas, United States

and more 62 locations

A Study of Avutometinib and Defactinib in People With Thyroid Cancer

Phase 2

Recruiting

Conditions: Thyroid Cancer

Interventions: Drug: Avutometinib
Drug: Defactinib

First Posted Date: 2023-08-23

Last Posted Date: 2025-01-03

Lead Sponsor: Memorial Sloan Kettering Cancer Center

Target Recruit Count: 30

Registration Number: NCT06007924

Locations: 🇺🇸
Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale, New Jersey, United States
🇺🇸
Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown, New Jersey, United States
🇺🇸
Memorial Sloan Kettering Nassau (Limited Protocol Activities), Rockville Centre, New York, United States

and more 4 locations

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