Nesiritide

Generic Name: Nesiritide

Brand Names: -

Drug Type: Biotech

Chemical Formula: -

CAS Number: 124584-08-3

Unique Ingredient Identifier: P7WI8UL647

Background: Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide.

Indication: 适用于急性代偿性心力衰竭、慢性失代偿性心力衰竭、心肌梗死、心脏导管手术等。由于静脉使用起效快，更适用于急性心力衰竭。

Associated Conditions: Acute Decompensated Heart Failure (ADHF)

Associated Therapies: -

Clinical Trials

Nesiritide and Renal Function After the Total Artificial Heart

Phase 4

Terminated

Conditions: Cardiorenal Syndrome
Congestive Heart Failure

Interventions: Drug: placebo
Drug: nesiritide

First Posted Date: 2013-04-22

Last Posted Date: 2016-02-08

Lead Sponsor: Virginia Commonwealth University

Target Recruit Count: 2

Registration Number: NCT01836809

Locations: 🇺🇸
Virginia Commonwealth University Medical Center, Richmond, Virginia, United States

Recombinant BNP on Heart and Renal Function in Acute Heart Failure

Phase 2

Conditions: Acute Heart Failure
Acute Renal Failure

Interventions: Drug: standard of care
Drug: rhBNP

First Posted Date: 2012-06-21

Last Posted Date: 2012-08-07

Lead Sponsor: Shanghai Chest Hospital

Target Recruit Count: 100

Registration Number: NCT01625403

Locations: 🇨🇳
Shanghai Chest Hospital, Shanghai, Shanghai, China

Tadalafil and Nesiritide as Therapy in Pre-clinical Heart Failure

Phase 1

Completed

Conditions: Congestive Heart Failure

Interventions: Drug: Nesiritide
Drug: Tadalafil
Drug: Placebo
Drug: Saline load

First Posted Date: 2012-03-06

Last Posted Date: 2018-03-22

Lead Sponsor: Mayo Clinic

Target Recruit Count: 43

Registration Number: NCT01544998

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

Does Nesiritide Provide Renal Protection

Phase 2

Completed

Conditions: Renal Failure

Interventions: Drug: Placebo
Drug: Nesiritide

First Posted Date: 2011-09-27

Last Posted Date: 2014-06-06

Lead Sponsor: University of Florida

Target Recruit Count: 37

Registration Number: NCT01440881

Locations: 🇺🇸
University of Florida, Gainesville, Florida, United States

Brain Natriuretic Peptide Effects on Appetite Regulating Hormones and Endothelial Derived Peptides

Not Applicable

Completed

Conditions: Healthy

Interventions: Drug: 0.9% NaCl
Drug: BNP

First Posted Date: 2011-06-17

Last Posted Date: 2017-04-06

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 10

Registration Number: NCT01375153

Locations: 🇦🇹
AKH, Medical University of Vienna, Vienna, Austria
🇦🇹
Medical University of Vienna, Vienna, Austria

Renal Optimization Strategies Evaluation in Acute Heart Failure and Reliable Evaluation of Dyspnea in the Heart Failure Network (ROSE) Study

Phase 2

Completed

Conditions: Acute Heart Failure

Interventions: Other: Placebo
Drug: Dopamine
Drug: Nesiritide

First Posted Date: 2010-05-28

Last Posted Date: 2014-08-21

Lead Sponsor: Duke University

Target Recruit Count: 360

Registration Number: NCT01132846

Locations: 🇺🇸
University of Utah Health Sciences Center, Murry, Utah, United States
🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
🇺🇸
University of Vermont- Fletcher Allen Health Care, Burlington, Vermont, United States

and more 5 locations

Low Dose Intravenous (IV) Infusion of BNP in the Presence and Absence of Acute Type V Phosphodiesterase (PDE V) in Improving Renal Function in Hospitalized Chronic Heart Failure (CHF) Patients With Renal Dysfunction

Phase 1

Completed

Conditions: Renal Dysfunction
Heart Failure

Interventions: Drug: BNP and PDE-V
Drug: BNP

First Posted Date: 2009-09-07

Last Posted Date: 2020-01-18

Lead Sponsor: Mayo Clinic

Target Recruit Count: 60

Registration Number: NCT00972569

Assessment of Biomarkers and Cardiorenal Syndrome in Acute Decompensated Heart Failure With Vasodilator Therapy

Phase 4

Completed

Conditions: Acute Decompensated Heart Failure

Interventions: Drug: Nesiritide
Drug: Nitroglycerin

First Posted Date: 2009-02-12

Last Posted Date: 2013-08-30

Lead Sponsor: Western University of Health Sciences

Target Recruit Count: 89

Registration Number: NCT00842023

Locations: 🇺🇸
Centinela Hospital Medical Center, Inglewood, California, United States

An Open-label, One-arm, Study to Evaluate the Hemodynamic Changes and Safety of Nesiritide for Acute Decompensated Heart Failure

Phase 3

Completed

Conditions: Heart Decompensation
Congestive Heart Failure

Interventions: Drug: Nesiritide

First Posted Date: 2008-12-22

Last Posted Date: 2014-02-28

Lead Sponsor: Xian-Janssen Pharmaceutical Ltd.

Target Recruit Count: 41

Registration Number: NCT00813202

Nesiritide - Dilated Cardiomyopathy

Not Applicable

Completed

Conditions: Dilated Cardiomyopathy

Interventions: Drug: 5% Dextrose
Drug: Nesiritide

First Posted Date: 2008-07-03

Last Posted Date: 2008-07-03

Lead Sponsor: University of California, Los Angeles

Target Recruit Count: 20

Registration Number: NCT00709163

Locations: 🇺🇸
Mattel Children's Hospital at UCLA, Los Angeles, California, United States

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