Melatonin
- Generic Name
- Melatonin
- Brand Names
- Circadin, Slenyto, Melatonin Neurim
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16N2O2
- CAS Number
- 73-31-4
- Unique Ingredient Identifier
- JL5DK93RCL
- Background
Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence ...
- Indication
Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for ...
- Associated Conditions
- Insomnia
- Associated Therapies
- -
Comparing Treatment With Melatonin to Treatment With Stimulants (Methylphenidate) in Children With Attention Deficit Hyperactivity Disorder and Sleep Difficulties
- Conditions
- Interventions
- First Posted Date
- 2011-07-13
- Last Posted Date
- 2011-07-13
- Lead Sponsor
- Assaf-Harofeh Medical Center
- Target Recruit Count
- 46
- Registration Number
- NCT01393574
- Locations
- 🇮🇱
Assaf Haroffeh Medical Center, Zeriffin, Israel
Melatonin Treatment for Tardive Dyskinesia in Schizophrenia
- First Posted Date
- 2011-07-12
- Last Posted Date
- 2016-07-12
- Lead Sponsor
- Beijing HuiLongGuan Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT01391390
- Locations
- 🇨🇳
Beijing HuiLongGuan hospital, Beijing, China
Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological Effects
- First Posted Date
- 2011-06-10
- Last Posted Date
- 2022-07-14
- Lead Sponsor
- Institution de Lavigny
- Registration Number
- NCT01370486
- Locations
- 🇨🇭
Institution de Lavigny, Lavigny, Vaud, Switzerland
Study With Amitriptylin to Evaluate the Efficacy of Melatonin in Treatment of Migraine
- First Posted Date
- 2011-05-20
- Last Posted Date
- 2015-12-30
- Lead Sponsor
- Hospital Israelita Albert Einstein
- Target Recruit Count
- 192
- Registration Number
- NCT01357031
- Locations
- 🇧🇷
Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Melatonin in Relapsing-Remitting Multiple Sclerosis Patients
- First Posted Date
- 2011-01-19
- Last Posted Date
- 2015-08-14
- Lead Sponsor
- Tehran University of Medical Sciences
- Target Recruit Count
- 25
- Registration Number
- NCT01279876
- Locations
- 🇮🇷
Iranian Center for Neurological Researches, Imam Khomeini Hospital, Tehran, Iran, Islamic Republic of
Evaluation of Anxiolysis and Pain Associated With Retrobulbar Eye Block for Cataract Surgery : Melatonin Versus Gabapentin
- First Posted Date
- 2010-09-13
- Last Posted Date
- 2012-10-11
- Lead Sponsor
- Qazvin University Of Medical Sciences
- Target Recruit Count
- 90
- Registration Number
- NCT01200641
- Locations
- 🇮🇷
Qazvin university of medical science, Qazvin, Iran, Islamic Republic of
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study
- First Posted Date
- 2010-05-03
- Last Posted Date
- 2015-12-18
- Lead Sponsor
- Emory University
- Target Recruit Count
- 37
- Registration Number
- NCT01114360
- Locations
- 🇺🇸
Emory University, Atlanta, Georgia, United States
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study
- First Posted Date
- 2010-05-03
- Last Posted Date
- 2016-02-26
- Lead Sponsor
- Emory University
- Target Recruit Count
- 40
- Registration Number
- NCT01114373
- Locations
- 🇺🇸
Emory University, Atlanta, Georgia, United States
Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia
- First Posted Date
- 2010-03-16
- Last Posted Date
- 2011-06-20
- Lead Sponsor
- Herlev Hospital
- Target Recruit Count
- 12
- Registration Number
- NCT01087359
- Locations
- 🇩🇰
Herlev Hospital, Herlev, Denmark
Melatonin and the Metabolic Syndrome
- First Posted Date
- 2009-12-24
- Last Posted Date
- 2015-02-27
- Lead Sponsor
- Emory University
- Target Recruit Count
- 39
- Registration Number
- NCT01038921
- Locations
- 🇺🇸
Emory University, Atlanta, Georgia, United States
🇺🇸Emory Hospital, Atlanta, Georgia, United States
Drug Development Updates
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