Melatonin
- Generic Name
- Melatonin
- Brand Names
- Circadin, Slenyto, Melatonin Neurim
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16N2O2
- CAS Number
- 73-31-4
- Unique Ingredient Identifier
- JL5DK93RCL
- Background
Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence ...
- Indication
Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for ...
- Associated Conditions
- Insomnia
- Associated Therapies
- -
Efficacy and Safety of Slenyto for Insomnia in Children With ASD
- First Posted Date
- 2020-01-18
- Last Posted Date
- 2021-03-12
- Lead Sponsor
- Neurim Pharmaceuticals Ltd.
- Registration Number
- NCT04233502
Effect of Topical Melatonin Application on Dental Implant Osseointegration and Marginal Bone Level
- First Posted Date
- 2020-01-18
- Last Posted Date
- 2020-10-06
- Lead Sponsor
- University of Baghdad
- Target Recruit Count
- 10
- Registration Number
- NCT04229719
- Locations
- 🇮🇶
College of Dentistry / University of Baghdad, Baghdad, Iraq
Rivastigmine Patch Compared to Melatonin Patch in Prevention of Postoperative Delirium
- Conditions
- Interventions
- First Posted Date
- 2019-12-06
- Last Posted Date
- 2020-07-09
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 180
- Registration Number
- NCT04189666
- Locations
- 🇪🇬
Ain Shams University, Cairo, Abassia, Egypt
Melatonin for Prevention of Post Stroke Delirium
- First Posted Date
- 2019-10-10
- Last Posted Date
- 2019-10-10
- Lead Sponsor
- University Hospital Tuebingen
- Target Recruit Count
- 2000
- Registration Number
- NCT04122599
- Locations
- 🇩🇪
Klinik für Neurologie, Tübingen, BW, Germany
Effects of Selenium and Melatonin on Ocular Ischemic Syndrome
- Conditions
- Interventions
- First Posted Date
- 2019-07-02
- Last Posted Date
- 2021-02-03
- Lead Sponsor
- Beytepe Murat Erdi Eker State Hospital
- Target Recruit Count
- 28
- Registration Number
- NCT04005222
The Effect of Melatonin on Postoperative Pain Reduction After Orthognathic Surgery
- Conditions
- Interventions
- First Posted Date
- 2019-06-21
- Last Posted Date
- 2022-06-03
- Lead Sponsor
- The University of Hong Kong
- Target Recruit Count
- 87
- Registration Number
- NCT03995004
- Locations
- 🇭🇰
Prince Philip Dental Hospital, Hong Kong, Hong Kong
Metabolic Effects of Melatonin Treatment
- First Posted Date
- 2019-03-01
- Last Posted Date
- 2021-08-25
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 17
- Registration Number
- NCT03859934
- Locations
- 🇩🇰
Medical Research Laboratory, Aarhus, Denmark
Effect of Melatonin and Metformin on Glycemic Control Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes
- First Posted Date
- 2019-02-20
- Last Posted Date
- 2019-09-26
- Lead Sponsor
- University of Guadalajara
- Target Recruit Count
- 42
- Registration Number
- NCT03848533
- Locations
- 🇲🇽
Institute of Experimental and Clinical Therapeutics (INTEC), CUCS, University of Guadalajara, Guadalajara, Jalisco, Mexico
Melatonin Cream Against Acute Radiation Dermatitis in Patients With Early Breast Cancer
- Conditions
- Interventions
- First Posted Date
- 2018-10-23
- Last Posted Date
- 2021-09-10
- Lead Sponsor
- Dennis Bregner Zetner
- Target Recruit Count
- 48
- Registration Number
- NCT03716583
- Locations
- 🇩🇰
Rigshospitalet, Copenhagen, Capital Region, Denmark
Evaluation of Melatonin Application of Immediate Dental Implant
- Conditions
- Interventions
- First Posted Date
- 2018-10-01
- Last Posted Date
- 2021-06-08
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 24
- Registration Number
- NCT03689998
- Locations
- 🇪🇬
Cairo University, Cairo, Egypt
Drug Development Updates
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