Perindopril

Generic Name: Perindopril

Brand Names: Aceon, Coversyl, Prestalia, Viacoram

Drug Type: Small Molecule

Chemical Formula: C_₁₉H_₃₂N_₂O_₅

CAS Number: 82834-16-0

Unique Ingredient Identifier: Y5GMK36KGY

Background: Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) ...

Indication: For the treatment of mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease.

Associated Conditions: Cardiovascular Events, Diabetic Nephropathy, Hypertension, Hypertension, Essential Hypertension, Myocardial Infarction, NYHA Class I Congestive heart failure, Stroke, Chronic heart failure with reduced ejection fraction (NYHA Class II), Chronic heart failure with reduced ejection fraction (NYHA Class III)

Associated Therapies: -

Clinical Trials

Phase II Study of Perindopril and Regorafenib in mCRC

Phase 2

Completed

Conditions: Metastatic Colorectal Cancer

Interventions: Drug: Regorafenib
Drug: Perindopril

First Posted Date: 2016-01-11

Last Posted Date: 2019-09-12

Lead Sponsor: British Columbia Cancer Agency

Target Recruit Count: 12

Registration Number: NCT02651415

Locations: 🇨🇦
BC Cancer Agency - Vancouver Cancer Centre, Vancouver, British Columbia, Canada

RAS Peptide Profiles in Patients With Arterial Hypertension

Completed

Conditions: Essential Hypertension

Interventions: Drug: Perindopril
Drug: Olmesartan
Drug: Hydrochlorothiazide
Drug: Amlodipine

First Posted Date: 2015-05-20

Last Posted Date: 2019-02-22

Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Target Recruit Count: 107

Registration Number: NCT02449811

Locations: 🇨🇭
University Hospital, Basel, Switzerland

DOXAZOSIN FOR PTSD

Phase 1

Completed

Conditions: PTSD

Interventions: Drug: doxazosin
Drug: Placebo
Drug: Perindopril

First Posted Date: 2014-12-04

Last Posted Date: 2022-04-26

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 30

Registration Number: NCT02308202

Locations: 🇺🇸
Baylor College of Medicine, Houston, Texas, United States

Effect of Valsartan vs Perindopril on HOMA-IR Index in Patients With Chronic Kidney Disease

Phase 4

Conditions: Chronic Kidney Disease

Interventions: Drug: Valsartan
Drug: Perindopril

First Posted Date: 2014-11-24

Last Posted Date: 2014-12-02

Lead Sponsor: Chinese PLA General Hospital

Target Recruit Count: 60

Registration Number: NCT02299310

Locations: 🇨🇳
Chinese PLA General Hospital, Beijing, Beijing, China

Perindopril and Telmisartan for the Treatment of Nonalcoholic Fatty Liver Disease

Phase 4

Conditions: Nonalcoholic Fatty Liver Disease (NAFLD)

Interventions: Drug: Perindopril
Drug: Telmisartan
Drug: Amlodipine

First Posted Date: 2014-08-11

Last Posted Date: 2014-08-11

Lead Sponsor: Nanfang Hospital, Southern Medical University

Target Recruit Count: 180

Registration Number: NCT02213224

Locations: 🇨🇳
Nanfang Hospital, Southern Medical University, GuangZhou, Guangdong, China

Telmisartan vs. Perindopril in Mild-Moderate Alzheimer's Disease Patients

Phase 2

Conditions: Alzheimer's Disease

Interventions: Drug: Perindopril
Drug: Telmisartan

First Posted Date: 2014-03-12

Last Posted Date: 2022-05-04

Lead Sponsor: Sunnybrook Health Sciences Centre

Target Recruit Count: 150

Registration Number: NCT02085265

Locations: 🇨🇦
Hamilton General Hospital, Hamilton, Ontario, Canada
🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
🇨🇦
Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada

and more 7 locations

Pilot Study of Perindopril in Childhood Cancer Survivors

Phase 2

Withdrawn

Conditions: Childhood Cancer Survivors

Interventions: Drug: Perindopril

First Posted Date: 2013-09-23

Last Posted Date: 2015-10-06

Lead Sponsor: The Hospital for Sick Children

Registration Number: NCT01948232

Locations: 🇨🇦
The Hospital for Sick Children, Toronto, Ontario, Canada

Stratification of Blood Pressure Control Against Progress of Cerebral Small Vessel Diseases in Poststroke Patients

Phase 4

Conditions: Cerebral Small Vessel Diseases

Interventions: Drug: Azelnidipine
Drug: Perindopril
Drug: hydrochlorothiazide

First Posted Date: 2013-03-27

Last Posted Date: 2015-10-23

Lead Sponsor: Yining Huang

Target Recruit Count: 1200

Registration Number: NCT01819441

Locations: 🇨🇳
Peking University First Hospital, Beijing, Beijing, China

PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors

Phase 3

Terminated

Conditions: Dilated Cardiomyopathy

Interventions: Drug: placebo
Drug: perindopril

First Posted Date: 2012-04-23

Last Posted Date: 2016-02-24

Lead Sponsor: Institut National de la Santé Et de la Recherche Médicale, France

Target Recruit Count: 6

Registration Number: NCT01583114

Locations: 🇬🇧
The Heart Hospital, University College London NHS Foundation Trust, London, United Kingdom
🇪🇸
Health in Code SL (SME) - Hospital Marítimo de Oza., A Coruña, Spain
🇫🇷
Pitié Salpêtrière Hospital, Paris, France

and more 4 locations

Perindopril Amlodipine for the Treatment of Hypertension

Phase 3

Completed

Conditions: Essential Hypertension

Interventions: Drug: XOMA 985
Drug: Perindopril Erbumine
Drug: Amlodipine Besylate

First Posted Date: 2012-03-19

Last Posted Date: 2015-09-28

Lead Sponsor: Symplmed Pharmaceuticals LLC

Target Recruit Count: 837

Registration Number: NCT01556997

Drug Development Updates

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