Alteplase
- Generic Name
- Alteplase
- Brand Names
- Activase, Cathflo, Cathflo Activase
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 105857-23-6
- Unique Ingredient Identifier
- 1RXS4UE564
- Background
Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplase and fibrin. Alteplase is a purified gl...
- Indication
Alteplase is indicated for the treatment of acute ischemic stroke (AIS) and for use in acute myocardial infarction (AMI) for the reduction of mortality and incidence of heart failure. Alteplase is also indicated for the lysis of acute massive pulmonary embolism, defined as acute pulmonary emboli obstructing blood flow to a lobe or multiple lung segments, and...
- Associated Conditions
- Acute Ischemic Stroke, Cardiac mortality, Heart Failure, Pulmonary Embolism Acute Massive, Central venous access device thrombosis
- Associated Therapies
- -
Antiplatelet vs R-tPA for Acute Mild Ischemic Stroke
- First Posted Date
- 2018-09-07
- Last Posted Date
- 2022-08-03
- Lead Sponsor
- General Hospital of Shenyang Military Region
- Target Recruit Count
- 760
- Registration Number
- NCT03661411
- Locations
- 🇨🇳
Lin Tao, ShenYang, China
Efficacy and Safety of CUSA-081 in the Restoration of Central Venous Access Device (CVAD) Functionality
- Conditions
- Interventions
- First Posted Date
- 2018-07-20
- Last Posted Date
- 2024-08-23
- Lead Sponsor
- Chiesi Farmaceutici S.p.A.
- Target Recruit Count
- 462
- Registration Number
- NCT03594175
- Locations
- 🇷🇴
Chiesi Invesitgational Site, Cluj-Napoca, Romania
🇺🇸Einspahr, Topeka, Kansas, United States
🇪🇸Chiesi Investigational Site, Sevilla, Spain
Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE
- Conditions
- Interventions
- First Posted Date
- 2018-07-10
- Last Posted Date
- 2024-10-03
- Lead Sponsor
- Northwell Health
- Target Recruit Count
- 31
- Registration Number
- NCT03581877
- Locations
- 🇺🇸
Long Island Jewish Medical Center, Queens, New York, United States
🇺🇸Southside Northwell Hospital, Bay Shore, New York, United States
Study of rhPro-UK in Patients With Acute Ischaemic Stroke in 4.5 Hours After Stroke Onset(PROST)
- Conditions
- Interventions
- First Posted Date
- 2018-05-30
- Last Posted Date
- 2020-06-22
- Lead Sponsor
- Tasly Biopharmaceuticals Co., Ltd.
- Target Recruit Count
- 674
- Registration Number
- NCT03541668
- Locations
- 🇨🇳
XuanWu Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳Beijing Luhe Hospital,Capital Medical University, Beijing, Beijing, China
🇨🇳The First Hospital of Handan, Handan, Hebei, China
Argatroban Plus r-tPA for Posterior Circulation Infarction（AR-PCI）
- Conditions
- Interventions
- First Posted Date
- 2018-04-23
- Last Posted Date
- 2018-11-14
- Lead Sponsor
- Hui-Sheng Chen
- Target Recruit Count
- 3
- Registration Number
- NCT03506009
- Locations
- 🇨🇳
General Hospital of Shenyang Military Region, Shenyang, Liaoning, China
Which Factors Influence the Duration and the Success of Mechanical Thrombectomy During the Acute Phase of Cerebral Infarction?
- First Posted Date
- 2018-03-02
- Last Posted Date
- 2018-03-29
- Lead Sponsor
- Centre Hospitalier Universitaire de Besancon
- Target Recruit Count
- 106
- Registration Number
- NCT03451903
Regisry of the Stroke Patients in Assiut University Hospital
- Conditions
- Interventions
- First Posted Date
- 2018-01-08
- Last Posted Date
- 2018-01-08
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 1
- Registration Number
- NCT03392792
Tirofiban for Patients Treated With Alteplase
- First Posted Date
- 2017-11-29
- Last Posted Date
- 2020-09-09
- Lead Sponsor
- Capital Medical University
- Target Recruit Count
- 30
- Registration Number
- NCT03357133
- Locations
- 🇨🇳
The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China
🇨🇳Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳Luzhou People's Hospital, Luzhou, Sichuan, China
Adjunctive, Low-dose tPA in Primary PCI for STEMI
- Conditions
- Interventions
- First Posted Date
- 2017-11-08
- Last Posted Date
- 2024-08-23
- Lead Sponsor
- Population Health Research Institute
- Target Recruit Count
- 210
- Registration Number
- NCT03335839
- Locations
- 🇨🇦
University of Calgary - Foothills Medical Centre, Calgary, Alberta, Canada
🇨🇦Hamilton General Hospital, Hamilton, Ontario, Canada
🇨🇦University of Alberta - Mazankowski Alberta Heart Insitute, Edmonton, Alberta, Canada
Intracranial Collaterals in Acute Stroke and Clinical Outcome
- First Posted Date
- 2017-10-17
- Last Posted Date
- 2021-09-16
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 40
- Registration Number
- NCT03311386
- Locations
- 🇪🇬
Assiut university, Assiut, Egypt
Drug Development Updates
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